Results 131 to 140 of about 919,409 (398)

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

An International Proficiency Test to Detect, Identify and Quantify Ricin in Complex Matrices

Toxins, 2015
While natural intoxications with seeds of Ricinus communis (R. communis) have long been known, the toxic protein ricin contained in the seeds is of major concern since it attracts attention of those intending criminal, terroristic and military misuse. In
Sylvia Worbs, Martin Skiba, Jennifer Bender, Reinhard Zeleny, Heinz Schimmel, Werner Luginbühl, Brigitte G. Dorner   +6 more
doaj   +1 more source

Proximity to Industrial Releases of Toxins and Childhood Respiratory, Developmental, and Neurological Diseases: Environmental Ascription in East Baton Rouge Parish [PDF]

Recent research by Legot et al. (2010a, 2010b) has identified East Baton Rouge Parish (EBR) as a locus of particularly high volumes of emissions of developmental neurotoxins, i.e., those toxins that put children’s health and, especially, learning ...
Bruce London, Cristina Legot, John Shandra   +2 more
core  

Occurrence of Alternaria mycotoxins and quantification of viable Alternaria spp. during the food processing of tomato products in Spain [PDF]

, 2018
The occurrence of two Alternaria mycotoxins, alternariol (AOH) and alternariol monomethyl ether (AME) and the presence of conidia from Alternaria spp., were investigated throughout the food production chain of two businesses, one which uses organic fruit
Crespo Sempere, Ana, Estiarte, Núria, Marín Sillué, Sònia, Ramos Girona, Antonio J., Sanchís Almenar, Vicente   +4 more
core   +2 more sources

The Biology of Pichia membranifaciens Killer Toxins

Toxins, 2017
The killer phenomenon is defined as the ability of some yeast to secrete toxins that are lethal to other sensitive yeasts and filamentous fungi.
I. Belda, J. Ruiz, A. Alonso, D. Marquina, Antonio Santos   +4 more
semanticscholar   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Dynamics of the cyanobacterial water bloom with focus to Microcystis and its relationship with environmental factors in Brno reservoir

Acta Universitatis Agriculturae et Silviculturae Mendelianae Brunensis, 2013
Our paper brings new information about long-term changes of the phytoplankton communities in the Brno reservoir with the focus on the Microcystis abundance using the semi-monthly monitoring data covering the period 2006–2012.
Lucie Straková, Radovan Kopp, Eliška Maršálková, Blahoslav Maršálek   +3 more
doaj   +1 more source

Recent Progress in Environmental Toxins-Induced Cardiotoxicity and Protective Potential of Natural Products [PDF]

, 2021
Yuanying Yang, Shanshan Wei, Bikui Zhang, Wenqun Li   +3 more
openalex   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

Validation of an LC-MS Method for Quantification of Mycotoxins and Characterization of Fungal Strains Occurring in Food and Feed

Chemosensors
Mycotoxins are naturally occurring secondary metabolites produced by specific fungal strains. They can cause adverse effects, posing a serious health threat to both humans and livestock.
Julien Masquelier, Emmanuel K. Tangni, Pierre Becker, Julie Sanders, Joëlle Laporte, Birgit Mertens   +5 more
doaj   +1 more source