Results 1 to 10 of about 62,098 (249)

Toxicity and immunogenicity of Enterotoxigenic Escherichia coli heat-labile and heat-stable toxoid fusion 3xSTa(A14Q)-LT(S63K/R192G/L211A) in a murine model. [PDF]

PLoS ONE, 2013
Diarrhea is the second leading cause of death to young children. Enterotoxigenic Escherichia coli (ETEC) are the most common bacteria causing diarrhea. Adhesins and enterotoxins are the virulence determinants in ETEC diarrhea.
Chengxian Zhang, David E Knudsen, Mei Liu, Donald C Robertson, Weiping Zhang, STa Toxoid Vaccine Consortium Group   +5 more
doaj   +2 more sources

Preparation and Evaluation of Alum Precipitate and Oil Adjuvant Multivalent Vaccines Against Clostridium perfringens [PDF]

Kafkas Universitesi Veteriner Fakültesi Dergisi, 2021
Enterotoxaemia is one of the hazardous diseases of the livestock. In Pakistan prophylaxis failure is due to the vaccination with type D monovalent vaccine.
Madeeha TARIQ, Aftab Ahmad ANJUM, Ali Ahmad SHEIKH, Ali Raza AWAN, Muhammad Asad ALI, Mian Muhammad Khubaib SATTAR, Shahid HUSSAIN, Tehreem ALI   +7 more
doaj   +3 more sources

COMPLEXATION OF CURCUMIN WITH BOVINE SERUM ALBUMIN AND DIPHTHERIA TOXOID CRM197 [PDF]

Biotechnologia Acta, 2023
Aim. The goal of the study is to demonstrate the binding sites for curcumin on the protein carriers - bovine serum albumin and diphtheria toxoid CRM197. BSA was chosen as a potential non-specific protein carrier because of its widely used in medicine as ...
Zhukova D.A. , Hrabovskyi O.O.
doaj   +1 more source

Safety and Immunogenicity of a 4-Component Toxoid-Based Staphylococcus aureus Vaccine in Rhesus Macaques

Frontiers in Immunology, 2021
Staphylococcus aureus is a leading cause of significant morbidity and mortality and an enormous economic burden to public health worldwide. Infections caused by methicillin-resistant S.
Arundhathi Venkatasubramaniam, Grant Liao, Eunice Cho, Rajan P. Adhikari, Tom Kort, Frederick W. Holtsberg, Karen E. Elsass, Dean J. Kobs, Thomas L. Rudge, Keith D. Kauffman, Nickiana E. Lora, Daniel L. Barber, M. Javad Aman, Hatice Karauzum   +13 more
doaj   +1 more source

Listeria delivers tetanus toxoid protein to pancreatic tumors and induces cancer cell death in mice

Science Translational Medicine, 2022
Pancreatic ductal adenocarcinoma (PDAC) is a highly metastatic disease. Tumors are poorly immunogenic and immunosuppressive, preventing T cell activation in the tumor microenvironment.
B. Selvanesan, D. Chandra, Wilber Quispe-Tintaya, Arthee Jahangir, Ankur Patel, K. Meena, Rodrigo Alberto Alves Da Silva, Madeline Friedman, L. Gabor, Olivia Khouri, S. Libutti, Ziqiang Yuan, Jenny Li, Sarah Siddiqui, A. Beck, L. Tesfa, W. Koba, J. Chuy, J. Mcauliffe, Rojin Jafari, D. Entenberg, Yarong Wang, J. Condeelis, Vera M. Desmarais, V. Balachandran, Xusheng Zhang, Ken Lin, C. Gravekamp   +27 more
semanticscholar   +1 more source

Generation and evaluation of specific activity and authenticity of recombinant vaccine designed preventing against Pseudomonas aeruginosa

Инфекция и иммунитет, 2021
The aim of the study was to obtain and characterize a recombinant vaccine for the immunoprophylaxis of infections caused by Pseudomonas aeruginosa. A set of two highly immunogenic P. aeruginosa recombinant proteins was used to create related vaccine. The
A. A. Kaloshin, E. M. Zimina, E. O. Kalinichenko, N. A. Mihailova   +3 more
doaj   +1 more source

SARS-CoV-2 RBD-Tetanus toxoid conjugate vaccine induces a strong neutralizing immunity in preclinical studies

bioRxiv, 2021
Controlling the global COVID-19 pandemic depends, among other measures, on developing preventive vaccines at an unprecedented pace. Vaccines approved for use and those in development intend to use neutralizing antibodies to block viral sites binding to ...
Y. Valdés-Balbín, Darielys Santana-Mederos, Lauren Quintero, S. Fernandez, Laura Rodriguez, B. S. Ramírez, R. Pérez, Claudia Acosta, Y. Méndez, M. G. Ricardo, Tays Hernández, Gretchen Bergado, Franciscary Pi, A. Valdes, T. Carmenate, Ubel Ramírez, R. Oliva, J. Soubal, Raine Garrido, Félix Cardoso, M. Landys, H. González, M. Fariñas, J. Enriquez, E. Noa, A. Suarez, Cheng Fang, L. A. Espinosa, Y. Ramos, L. González, Yanet Climent, G. Rojas, Ernesto Relova-Hernández, Y. Infante, Sum Lai Losada, T. Boggiano, E. Ojito, K. L. Monzón, F. Chiodo, F. Paquet, Guang-Wu Chen, Daniel G. Rivera, D. García-Rivera, V. Verez-Bencomo   +43 more
semanticscholar   +1 more source

Production, immunogenicity, stability, and safety of a vaccine against Clostridium perfringens beta toxins [PDF]

Veterinary World, 2020
Background and Aim: The beta toxin is causing the most severe Clostridium perfringens-related diseases. This work was dedicated to developing a vaccine against beta toxin using C. perfringens type C (NCTC 3180). Materials and Methods: The crude toxoid
Mohamed J. Saadh, Issam J. Sa'adeh, Moeen F. Dababneh, Ammar M. Almaaytah, Mohammad F. Bayan   +4 more
doaj   +1 more source

Individual and community-level determinants of poor tetanus toxoid immunization among pregnant women in Ethiopia using data from 2016 Ethiopian demographic and health survey; multilevel analysis

Archives of Public Health, 2021
Background Tetanus is a vaccine-preventable disease that can occur in all populations, with neonates and pregnant women being at the most risk. Ethiopia has the highest maternal and neonatal tetanus morbidity and mortality rates.
Alemneh Mekuriaw Liyew, Hiwot Ayalew
semanticscholar   +1 more source

Effect of the vaccination against Shiga toxin 2e in a farm with history of oedema disease, caused by atypical Escherichia coli producing Shiga toxin (STEC)

Veterinární Medicína, 2022
Oedema disease of weaned piglets is caused by shigatoxigenic Escherichia coli (STEC), typically harbouring the stx2e gene and F18 adhesins. The aim of this study was to assess the effect of a commercially available oedema disease vaccine on the ...
D Sperling, N Isaka, H Karembe, J Vanhara, J Vinduska, N Strakova, A Kalova, IvKolackova, R Karpiskova   +8 more
doaj   +1 more source