Results 91 to 100 of about 143,360 (244)

Synthesis and biological evaluation of anti-Toxoplasma gondii activity of a novel scaffold of thiazolidinone derivatives [PDF]

, 2017
We designed and synthesised novel N-substituted 1,3-thiazolidin-4-one derivatives for the evaluation of their anti-Toxoplasma gondii efficacy. This scaffold was functionalised both at the N1-hydrazine portion with three structurally different moieties ...
Bizzarri, Bruna, Bordón, Claudia, Campestre, Cristina, Carradori, Simone, Chimenti, Paola, DE MONTE, Celeste, Guglielmi, Paolo, Jones Brando, Lorraine, Rivanera, Daniela, Secci, Daniela   +9 more
core   +1 more source

The Secreted Acid Phosphatase Domain-Containing GRA44 from Toxoplasma gondii Is Required for c-Myc Induction in Infected Cells. [PDF]

, 2020
During host cell invasion, the eukaryotic pathogen Toxoplasma gondii forms a parasitophorous vacuole to safely reside within the cell, while it is partitioned from host cell defense mechanisms.
Arrizabalaga, Gustavo, Blakely, William J., Holmes, Michael J.   +2 more
core   +2 more sources

Human impact on the diversity and virulence of the ubiquitous zoonotic parasite Toxoplasma gondii

Proceedings of the National Academy of Sciences of the United States of America, 2018
Significance A majority of emerging infectious diseases in humans are transmitted from animals. It is generally agreed that our behavior can influence our exposure to such pathogens, but little is known regarding our role in shaping evolution in such ...
E. K. Shwab, P. Saraf, Xing-Quan Zhu, Dong‐Hui Zhou, Brent M. McFerrin, D. Ajzenberg, G. Schares, Kenneth Hammond-Aryee, P. V. van Helden, Steven A. Higgins, Richard W. Gerhold, Benjamin M. Rosenthal, Xiaopeng Zhao, J. Dubey, C. Su   +14 more
semanticscholar   +1 more source

Phenotypic characteristics of paroxysmal dyskinesia in 25 cats

Journal of Small Animal Practice, EarlyView.
Objectives Paroxysmal dyskinesia has, to date, been reported only systematically in Sphynx cats. This study aims to describe paroxysmal dyskinesia in additional breeds. Materials and Methods The medical records of cats from multiple hospitals presenting with episodes consistent with paroxysmal dyskinesia between 2020 and 2025 were retrospectively ...
T. Liatis, C. Maeso, A. De Stefani, A. Pergande, T. Elvira, A. Suñol   +5 more
wiley   +1 more source

Analysis of the Correlation Between Toxoplasma gondii Seropositivity and Alzheimer’s Disease

Pathogens
Alzheimer’s disease (AD) is a multifactorial brain disorder and infectious diseases are considered as one of the predisposing factors for AD. Toxoplasma gondii, an obligate intracellular parasitic protozoan, is suspected of being associated with AD ...
Jianjun Wang, Ping Lin, Dan Li, Biyu Yang, Jiaqi Wang, Meng Feng, Xunjia Cheng   +6 more
doaj   +1 more source

P2X7 receptor mediates NLRP3-dependent IL-1β secretion and parasite proliferation in Toxoplasma gondii-infected human small intestinal epithelial cells

Parasites & Vectors, 2018
Toxoplasma gondii can invade and replicate in all nucleated cells in a wide range of host species, and infection induces IL-1β production. IL-1β plays central roles in the stimulation of the innate immune system and inflammation. However, little is known
J. Quan, Rui Huang, Zhuang Wang, Shuai Huang, In-Wook Choi, Yu Zhou, Young-Ha Lee, Jia-Qi Chu   +7 more
semanticscholar   +1 more source

Immune dysregulation in mania: A proof‐of‐concept platelet proteomics study

Psychiatry and Clinical Neurosciences, EarlyView.
Aims Bipolar disorder (BD) is a major psychiatric condition with a multifaceted and largely unknown pathophysiology. Mania, the defining feature of BD, remains underinvestigated. Proteomics offers a powerful, data‐driven, unbiased approach to uncover biological alterations.
Paola Magioncalda, Matteo Martino, Nhi Thao Ngoc Le, Wen‐Yin Chen, Ming‐Chyi Huang, David Blum, Thierry Burnouf   +6 more
wiley   +1 more source

INVESTIGATION OF TOXOPLASMA INFECTIONS IN NATIVE POULTRY OF TABRIZ CITY USING ELISA AND INDIRECT IMMUNOFLUORESCENCE METHODS [PDF]

Exploratory Animal and Medical Research, 2017
Toxoplasma gondii is widely distributed in humans and other animals and birds throughout the world. Toxoplasmosis is a common zoonotic infection in the world and in immune-deficient patients, it may cause acute and lethal infection.
Muhammad Fathollahzadeh, Yagoob Garedaghi   +1 more
doaj  

Preparation of colloidal gold immunochromatographic test strips for the diagnosis of Toxoplasma gondii

Food and Agricultural Immunology, 2020
As a severely harmful zoonotic disease, toxoplasmosis has complex clinical symptoms with atypical lesions, thus making it difficult for diagnosis in a timely manner. Therefore, developing an appropriate technique to diagnose and prevent toxoplasmosis has
Yuanxi Shen, Zhaozhe Wang, Jiajing Li, Rui Xu, Rongyi Ji, Jiaojiao Lin, Chuangang Zhu   +6 more
doaj   +1 more source

High levels of congenital transmission of toxoplasma gondii in longitudinal and cross-sectional studies on sheep farms provides evidence of vertical transmission in ovine hosts [PDF]

, 2005
Recent research suggests that vertical transmission may play an important role in sustaining Toxoplasma gondii infection in some species. We report here that congenital transmission occurs at consistently high levels in pedigree Charollais and outbred ...
Duncanson, P, Hide, G, Hughes, JM, Morley, EK, Smith, JE, Terry, RS, Williams, RH   +6 more
core   +1 more source