Results 11 to 20 of about 149,461 (135)

Broad‐Spectrum Engineered Multivalent Nanobodies Against SARS‐CoV‐1/2 [PDF]

Advanced Science, Volume 11, Issue 45, December 4, 2024.
This study presents the design and development of multivalent nanobodies targeting conserved epitopes of SARS‐CoV‐1 and SARS‐CoV‐2. The trivalent nanobody B11‐E8‐F3 exhibits broad‐spectrum neutralization against SARS‐CoV‐1 and multiple SARS‐CoV‐2 variants, including Omicron sublineages, and demonstrates significant preventive and therapeutic efficacy ...
Zhihong Wang, Zhuangzhuang Shi, Xiaochen Liao, Guiqi Quan, Hui Dong, Pinnan Zhao, Yangyihua Zhou, Ning Shi, Jie Wang, Yahui Wu, Chunxia Qiao, Xin ying Li, Ran Zhang, Zekun Wang, Tiecheng Wang, Xiang Gao, Jiannan Feng, Longlong Luo   +17 more
wiley   +2 more sources

EHA2024 Hybrid Congress [PDF]

Hemasphere
HemaSphere, Volume 8, Issue S1, June 2024.
wiley   +2 more sources

Ginsentide TP1 Protects Hypoxia-Induced Dysfunction and ER Stress-Linked Apoptosis

bioRxiv, 2023
Hypoxia-induced vascular endothelial dysfunction (VED) is a significant contributor to several severe human conditions, including heart disease, stroke, dementia, and cancer.
Bamaprasad Dutta, Shining Loo, A. Kam, S. Sze, James P. Tam   +4 more
semanticscholar   +1 more source

Insights into the equilibrium structure and translocation mechanism of TP1, a spontaneous membrane-translocating peptide

Scientific Reports, 2022
Crossing the cellular membrane is one of the main barriers during drug discovery; many potential drugs are rejected for their inability to integrate into the intracell fluid.
D. Muñoz-Gacitúa, F. Gúzman, B. Weiss-Lopez   +2 more
semanticscholar   +1 more source

Sequence Diversity of Tp1 and Tp2 Antigens and Population Genetic Analysis of Theileria parva in Unvaccinated Cattle in Zambia’s Chongwe and Chisamba Districts

Pathogens, 2022
East Coast Fever (ECF), caused by Theileria parva, is a major constraint to improved livestock keeping in east and central Africa, including Zambia. To understand the dynamics and determine the candidates for immunization in Zambia’s Chongwe and Chisamba
Walter Muleya, David Kalenzi Atuhaire, Z. Mupila, V. Mbao, Purity Mayembe, Sydney Kalenga, P. Fandamu, B. Namangala, J. Salt, A. Musoke   +9 more
semanticscholar   +1 more source

Solving the Single-Valued Trapezoidal Neutrosophic Transportation Problems through the Novel Dhouib-Matrix-TP1 Heuristic

Mathematical Problems in Engineering, 2021
The transportation problem has been widely studied in the field of supply chain management where circulation of products with a minimal transportation cost is an important issue. This paper presents the first adaptation of the Dhouib-Matrix-TP1 heuristic
Souhail Dhouib
semanticscholar   +1 more source

Solving the Trapezoidal Fuzzy Transportation Problems via New Heuristic: The Dhouib-Matrix-TP1

International Journal of Operations Research and Information Systems, 2021
The transportation problem is a one of the principal topics in operational research where goods are initially stored at different sources and need to be livered to destination in such a way the total transportation cost is minimum.
Souhail Dhouib
semanticscholar   +1 more source

The miR-1185-2-3p—GOLPH3L pathway promotes glucose metabolism in breast cancer by stabilizing p53-induced SERPINE1

Journal of experimental & clinical cancer research : CR, 2021
Background Phosphatidylinositol-4-phosphate-binding protein GOLPH3L is overexpressed in human ductal carcinoma of the breast, and its expression levels correlate with the prognosis of breast cancer patients.
Youqin Xu, Wancheng Chen, Jing Liang, X. Zeng, Kai-yuan Ji, Jianlong Zhou, Shijun Liao, Jiexian Wu, Kongyang Xing, Zilong He, Yang Yang, Qianzheng Liu, Pingyi Zhu, Yuchang Liu, Li Li, Min-feng Liu, Wenxiao Chen, Wenhua Huang   +17 more
semanticscholar   +1 more source

Low-dose radiotherapy for painful osteoarthritis of the elderly: A multicenter analysis of 970 patients with 1185 treated sites

Strahlentherapie und Onkologie (Print), 2021
Painful osteoarthritis is common in elderly patients, and low-dose radiotherapy has been demonstrated to provide effective symptomatic treatment. We examined the analgesic effects of low-dose radiotherapy for osteoarthritis in the elderly aiming to ...
A. Rühle, Elisabeth Tkotsch, Rainer Mravlag, E. Haehl, S. Spohn, C. Zamboglou, P. Huber, J. Debus, A. Grosu, T. Sprave, N. Nicolay   +10 more
semanticscholar   +1 more source

Diagnostic efficacy of FibroScan for liver inflammation in patients with chronic hepatitis B: a single-center study with 1185 liver biopsies as controls

BMC Gastroenterology, 2021
Background Noninvasive diagnostic technologies that can dynamically monitor changes in liver inflammation are highly important for the management of chronic hepatitis B (CHB) patients and thus warrant further exploration.
Kai-qing Jiang, Lei Zhang, Jianhong Li, Hong-rong Hu, Qing-xiu Huang, Tengyu Qiu, X. Mo, Jianlin Ren, Wen-fang Guo, Y. Tao, Hai-zhen Cui, Y. Zuo, Xuli Chen, Youqing Xie, Yan-Xia Li, Hai-jun Liang, Zhaohong Liu, L. Xie, Rongjun Mao, Q. Jiang, Kai-Zhao Huang   +20 more
semanticscholar   +1 more source