Results 11 to 20 of about 270,020 (316)

Neutrophil extracellular traps promote tPA-induced brain hemorrhage via cGAS in mice with stroke

Blood, 2021
Thrombolysis is the only approved therapy for acute ischemic stroke, but its success is limited by secondary hemorrhage. Wang and colleagues report that infusion of tissue plasminogen activator (tPA) in a murine stroke model results in increased ...
Ranran Wang, Yuanbo Zhu, Zhongwang Liu, Luping Chang, Xiaofei Bai, Lijing Kang, Yongliang Cao, Xing Yang, Huilin Yu, Mei-Juan Shi, Yue Hu, Wenying Fan, Bing-Qiao Zhao   +12 more
semanticscholar   +1 more source

Intracellular tPA–PAI-1 interaction determines VLDL assembly in hepatocytes

Science, 2023
Apolipoprotein B (apoB)–lipoproteins initiate and promote atherosclerotic cardiovascular disease. Plasma tissue plasminogen activator (tPA) activity is negatively associated with atherogenic apoB-lipoprotein cholesterol levels in humans, but the ...
Wenqin Dai, Heng Zhang, H. Lund, Ziyu Zhang, Mark Castleberry, Maya Rodríguez, G. Kuriakose, Sweta Gupta, Magdalena D. Lewandowska, Hayley R. Powers, Swati Valmiki, Jieqing Zhu, A. Shapiro, M. Hussain, José A. López, M. Sorci-Thomas, R. Silverstein, H. Ginsberg, D. Sahoo, I. Tabas, Ze Zheng, Gfp Cre   +21 more
semanticscholar   +1 more source

Ten-Year Trend in Age, Sex, and Racial Disparity in tPA (Alteplase) and Thrombectomy Use Following Stroke in the United States

Stroke, 2021
Supplemental Digital Content is available in the text. Background and Purpose: IV tPA (intravenous thrombolysis with alteplase) and mechanical thrombectomy (MT) utilization increased in acute ischemic stroke hospitalizations in the United States over the
F. Otite, Vasu Saini, Nicole B. Sur, Smit D. Patel, Richa Sharma, E. Akano, N. Anikpezie, K. Albright, E. Schmidt, H. Hoffman, G. Gould, P. Khandelwal, J. Latorre, A. Malik, R. Sacco, S. Chaturvedi   +15 more
semanticscholar   +1 more source

tPA Mobilizes Immune Cells that Exacerbate Hemorrhagic Transformation in Stroke.

Circulation Research, 2020
Rationale: Hemorrhagic complications represent a major limitation of intravenous thrombolysis using tissue plasminogen activator (tPA) in patients with ischemic stroke.
Kaibin Shi, M. Zou, Dongmei Jia, Samuel X. Shi, Xiaoxia Yang, Qiang Liu, Jing-fei Dong, K. Sheth, Xiaoying Wang, F. Shi   +9 more
semanticscholar   +1 more source

Recycled Asphalt Pavement (RAP) as a fully valuable component of the HMA mixes

Budownictwo i Architektura, 2014
Currently produced HMA mixes have to meet a certain requirements for a finished product. European product standards and Polish technical guidelines contain all relevant regulations and requirements regarding HMA.
Piotr Koźlarek
doaj   +1 more source

NF-κB and tPA Signaling in Kidney and Other Diseases

Cells, 2020
The activation of the nuclear factor-κB (NF-κB) pathway plays a central role in the initiation and progression of inflammation, which contributes to the pathogenesis and progression of various human diseases including kidney, brain, and other diseases ...
S. White, Ling Lin, Kebin Hu
semanticscholar   +1 more source

Truths and myths concerning affinity between asphalt and aggregate tested in accordance with PN-EN 12697-11

Budownictwo i Architektura, 2014
Very important element, which shall be taken into account while designing asphalt mixes, is the physicochemical affinity of asphalt binder to aggregate. There are many test methods for its determination, but the results can be totally different.
Monika Zięba, Sebastian Witczak
doaj   +1 more source

Approximate minimum BER power allocation for MIMO-THP system [PDF]

, 2008
This paper proposes a transmit power allocation (TPA) scheme based on multiple-input multiple-output (MIMO) Tomlinson-Harashima precoding (THP) structure, where a TPA matrix is introduced to the conventional MIMO-THP.
Gong, Ping, Lv, Tiejun, Su, Xinghui, Yang, Shaoshi, Yun, Xiang   +4 more
core   +1 more source

Trends of r-tPA (Recombinant Tissue-Type Plasminogen Activator) Treatment and Treatment-Influencing Factors in Acute Ischemic Stroke

Stroke, 2020
Supplemental Digital Content is available in the text. Background and Purpose— Frequencies of treatment with r-tPA (recombinant tissue-type plasminogen activator) are increasing over the past 15 years.
M. Marko, A. Posekany, S. Szabo, S. Scharer, S. Kiechl, M. Knoflach, W. Serles, J. Ferrari, W. Lang, P. Sommer, S. Greisenegger   +10 more
semanticscholar   +1 more source

Analysis of deformations of road embankments founded on displacement columns improving soft subsoil [PDF]

Archives of Civil Engineering
Drilled displacement columns, constructed in the form of unreinforced or reinforced concrete elements, are currently a very commonly used method of improving soft subsoil, creating an alternative to more expensive pile foundations.
Waldemar Szajna, Liudmyla Bondareva, Bartosz Szatanik   +2 more
doaj   +1 more source