Results 111 to 120 of about 80,997 (253)
BMC Pharmacology and ToxicologyBackground Topiramate (TPM) is a sulfamate-substituted monosaccharide known for its wide-ranging effects on epilepsy, neuropathic pain, and migraines.
Ray-Chang Tzeng +3 more
doaj +1 more source
Advanced Science, EarlyView.Single‐cell host–bacterial 16S co‐sequencing (scH16S‐seq) integrates cell‐associated bacterial 16S‐derived signals with host transcriptomes to resolve bacterial signal‐enriched myeloid states in Klebsiella pneumoniae sepsis. Complementary pharmacological and genetic analyses define a CD38–NAD immunometabolic axis connecting mitochondrial bioenergetic ...
Yangguang Li +15 more
wiley +1 more source
Enhancing Specific Stiffness of Nano‐Architected Materials Through Generative AI and Active Learning
Advanced Science, EarlyView.A structure‐centric generative framework searches voxelated design space directly, coupling a variational autoencoder with multi‐objective optimization and active learning to progressively expand the validated design domain. The discovered nano‐architectures, realized as pyrolytic carbon by two‐photon lithography, deliver 18–23% higher stiffness and 26–
Jinwook Yeo +4 more
wiley +1 more source
工程科学与技术, 2007 :a new de-cross-correlation preprocessing idea based on time axis perturbation method (TPM), which utilized the fact that hearing perception is not sensitive to the phase distortion of a speech signal, was proposed to solve the non-unique problem (NUP ...
doaj
PLoS ONEBackgroundNigeria is among the countries with a high burden of Teenage Pregnancy and Motherhood (TPM) in sub-Saharan Africa. The adverse effect of TPM on young girls is enormous and often compromises their future socioeconomic advancement, including ...
Mobolaji M Salawu +3 more
doaj +1 more source
Advanced Science, EarlyView.This study identifies Nupr1 as a crucial stress‐responsive orchestrator driving AD. Under severe stress, Nupr1 massively accumulates within mitochondria to sequester p53, triggering apoptosis and concurrently repressing the Gadd45b‐mediated survival program.
Xi Yang +14 more
wiley +1 more source
Mit TPM Veränderungen beherrschen
, 2022 S.167-184Always being able to adapt to new challenges of the market and the development of one's own company are two main topics of every board meeting. Furthermore in general every company is willing to achieve the economic and social maximum from their
Heller, Thomas
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Advanced Science, EarlyView.A lactate‐H3K18la epigenetic axis upregulates RPL11 to drive gemcitabine resistance in pancreatic cancer. RPL11 orchestrates chemoresistance through a dual, compartmentalized role: enhancing cytoplasmic protein synthesis via EEF1A1 stabilization and promoting nuclear DNA damage repair by co‐activating PARP14, thus ensuring robust cell survival ...
Lijun Zhao +10 more
wiley +1 more source
Tpm^Ph Derivative of Tungsten; Hydrogen-Bonding in 7-Coordinate Cation Complex [PDF]
Tpm^Ph, or tris(3-phenylpyrazolyl)methane reacts with tungsten hexacarbonyl to form the ligand-metal complex tris(3-phenylpyrazolyl)methane tungsten tricarbonyl, or Tpm^PhW(CO)3. The further complexes of Tpm^PhW(CO)3 and Tpm^PhMo(CO)3 are not known. This
Simcox, Olivia Ryon
core +1 more source
Lean TPM : a blueprint for change /
Lean TPM is an accessible, step-by-step guide designed to help you increase manufacturing efficiency through continuous improvement. Based on their experience of working with organizations that have successfully achieved outstanding performance, McCarthy
Rich, Nick,author. +1 more
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