Results 141 to 150 of about 80,997 (253)

Physiologically Based Pharmacokinetic Modeling to Characterize the Disposition of Topiramate in Children with and without Obesity. [PDF]

J Clin Pharmacol
Maglalang PD, Gonzalez D, Muller WJ, Hornik CD, Goldstein SL, Rathore M, Ford JL, Balevic SJ, Sinha J, Edginton A, Greenberg RG, Benjamin DK, Chen JY, Zimmerman KO, Best Pharmaceuticals for Children Act–Pediatric Trials Network Steering Committee.   +14 more
europepmc   +1 more source

A CT Lesion Foundation Model for Non‐Invasive Assessment of Hepatocellular Carcinoma Aggressiveness and Prediction of Recurrence Risk

Advanced Science, EarlyView.
A computed tomography lesion foundation model, built by sequential self‐supervised pretraining on generic and hepatocellular carcinoma‐specific lesion images, non‐invasively assesses microvascular invasion and pathological grade from contrast‐enhanced CT and stratifies postoperative recurrence risk.
Wei Xia, Zhehan Shen, Mengsi Li, Jianxin Lu, Ji Xia, Yang Cheng, Wenzheng Li, Shunjie Dong, Lin Deng, Ruokun Li   +9 more
wiley   +1 more source

Moderate-intensity treadmill exercise improved the anticonvulsant efficacy of topiramate and attenuated anxiety and depressive-like side effects in epileptic rats by upregulating 5-HT1A receptors in the hippocampus and cerebral cortex. [PDF]

IBRO Neurosci Rep
Goudarzi G, Aliyari B, Soleimani M, Vahabzadeh G, Rasoolijazi H, Karimzadeh F.   +5 more
europepmc   +1 more source

Early‐Life Polyethylene Microplastic Exposure Exacerbates ADHD‐Like Behaviors in Mice via PI3K/AKT1/Nrf2 Signaling: Evidence From the Pilot Cohort and Multi‐Omics Analyses

Advanced Science, EarlyView.
Circulating polyethylene microplastic burden is positively associated with heightened ADHD symptom severity and systemic redox‐inflammatory imbalance in children. Mechanistic investigation in a developmental co‐exposure mouse model further demonstrates that microplastics aggravate ADHD‐like behaviors, dopaminergic dysregulation, and oxidative ...
Yufan Luo, Ruijin Xie, Hua Xu, Xue Xiao, Wei Xiao, Qiyang Pan, Shengjie Xu, Li Liu, Zeliang Xiao, Yue Zhou, Chenyu Sun, Yu Wu, Yueying Liu   +12 more
wiley   +1 more source

RNA sequencing depth guidelines for the study of alternative splicing. [PDF]

Nucleic Acids Res
Chervontseva Z, Tsoy O, Hackl LM, Ameling S, Franzenburg S, Hoffmann M, Liv-Willuth L, Lee HK, Knabl L, Furth PA, Völker U, Hennighausen L, Baumbach J, Kacprowski T, List M.   +14 more
europepmc   +1 more source

Bacillus Licheniformis‐Induced Cognitive Decline in Mice Linking Gut Microbiota Dysbiosis, Metabolic Perturbations, and Hippocampal Neuroinflammation

Advanced Science, EarlyView.
Chronic oral administration of specific probiotic strains triggers gut microbiota dysbiosis and systemic metabolic perturbations in mice. Multi‐omics profiling reveals subsequent hippocampal glial remodeling and neuroinflammation, which are linked to cognitive impairment.
Yibin Lin, Afeng Wang, Hongchang Zhou, Yuliang Sun, Yingying Guo, Keyu Chen, Junhong Sun, Tinliang Lin, Zhaochen Huang, Xinhua Qiang, Jie He, Jianlin Lou, Yunliang Yao, Shengwen Shao, Yongliang Pan, Xiang Wang   +15 more
wiley   +1 more source

Rapid, label-free differentiation of benign and malignant gastric lesions using two-photon microscopy and quantitative collagen analysis. [PDF]

J Transl Int Med
Ning B, Zhou X, Guan K, Yan B, Chen Q, Li J, Liu S, Shao Q, Sun L, Zhang S, Ji X, Li D, Zang J, Linghu E.   +13 more
europepmc   +1 more source

Matrix Stiffness Promotes Tumor Metastasis by Triggering Recycling Endosome‐Mediated YY1 Nuclear Translocation and Transcriptional Activity

Advanced Science, EarlyView.
In stiff extracellular matrix (ECM), integrin αVβ3 transduces mechanical cues of ECM stiffness to promote recycling endosome formation, creating a signaling platform for yin yang 1 (YY1)/p21‐activated kinase 4 (PAK4) binding, but not in soft ECM. Then, this triggers PAK4‐mediated YY1 phosphorylation at S118, subsequent YY1 nuclear translocation and ...
Fuqiang Zhao, Xinpeng Wen, Jingyi Liu, Hongqiang Yu, Tianzhu Cui, Makoto Miyagishi, Vivi Kasim, Shourong Wu   +7 more
wiley   +1 more source

An integrative meningioma surfaceome atlas and a transferable framework for CAR-T target nomination. [PDF]

Front Bioinform
Sanker V, Mahesh D, Liverani L, Abikenari MA, Li Z, Zhang Y, Theodros D, Medikonda R, Cavagnaro MJ, Banu MA, Desai A, Lim M.   +11 more
europepmc   +1 more source

Degradation Mechanism of Phosphate‐Based Li‐NASICON Conductors in Alkaline Environment

Advanced Energy Materials, Volume 15, Issue 11, March 18, 2025.
The presence of water in the cathode of a Li‐air battery shifts reactions to produce LiOH, creating a corrosive, alkaline environment. This study investigates the alkaline stability of the common Li‐NASICON solid‐state conductor chemistries through a systematic experimental study combined with computational modeling to understand the degradation ...
Benjamin X. Lam, Zhuohan Li, Tara P. Mishra, Gerbrand Ceder   +3 more
wiley   +1 more source