Results 161 to 170 of about 80,997 (253)

A Plasmodium knowlesi A1-H.1 transcriptome time course focusing on the late asexual blood stages. [PDF]

PLoS Pathog
De Meulenaere K, Díaz-Delgado D, Monsieurs P, Sauve E, Cortés A, Knuepfer E, Rosanas-Urgell A.   +6 more
europepmc   +1 more source

Cross‐Species Single‐Cell Comparative Analysis Reveals Gluconeogenic Features of Hepatocytes in Ruminants

Animal Research and One Health, EarlyView.
In this study, we used cross‐species comparisons to identify ruminant hepatocyte features. We also identified potential genes and TFs involved in coordinating gluconeogenesis in ruminant hepatocytes. By integrating single‐cell data with population genetic analyses, we further identified candidate genetic variation in glucose metabolism and ...
Yaqi Zhou, Wuqiang Huo, Yingran Liu, Yihang Liu, Fei Wang, Tao Shi, Yu Jiang   +6 more
wiley   +1 more source

The antinociceptive effects of topiramate evaluated in writhing test in mice

Current Issues in Pharmacy and Medical Sciences
In the present study the antinociceptive activity of topiramate (TPM), new antiepileptic drug with multiple mechanism of action, in writhing test in mice was evaluated.
Antonina Mazur, Sylwia Fidecka
doaj  

Two-Photon Fluorescence and Second-Harmonic Generation Microscopy: Principles and Biomedical Applications. [PDF]

J Biophotonics
Makkithaya KN, Raju G, Das S, Patil A, Kumar R, Kistenev YV, Zhuo GY, Mazumder N.   +7 more
europepmc   +1 more source

Pathophysiological Mechanisms of Emaciation Syndrome in Plectropomus leopardus: Insights From Histology and Transcriptomics

Animal Research and One Health, EarlyView.
Integrated phenotypic, histological, transcriptomic, and validation analyses reveal that emaciation syndrome in Plectropomus leopardus is associated with intestinal structural damage, hepatic metabolic remodeling, and muscle protein degradation, highlighting coordinated multi‐tissue alterations underlying disease progression.
Zhihao Zhang, Bo Wang, Mengya Wang, Haizhan Tang, Mingjian Liu, Da Zheng, Zhongyi Zhai, Jiahang Li, Jinyang Xie, Chaofan Jin, Jingjie Hu, Zhenmin Bao   +11 more
wiley   +1 more source

A Phase I study of the pharmacokinetics (PK), bioavailability, dose proportionality, safety, and tolerability of topiramate injection compared to Oral topiramate in healthy adult participants. [PDF]

Epilepsia
Bamgboye AO, Cloyd JC, King BD, Coles LD.   +3 more
europepmc   +1 more source

Cumulative Reproductive‐Lactation Burdens Induce a Systemic Immunometabolic Trade‐Off Between Milk Yield and Mammary Health of Dairy Cows

Animal Research and One Health, EarlyView.
A population‐scale longitudinal transcriptomic atlas reveals how lactation stage and parity reshape systemic gene regulation in dairy cows. Multiomics‐inspired analyses uncover dynamic immune and metabolic adaptations that contribute to reproductive longevity and sustained productivity across the bovine lifespan.
Yangyang Shen, Zhenjiang An, Yingying Jiang, Zijian Huang, Kunlin Chen, Yundong Gao, Jianbin Li, Shuwen Xia, Huili Wang   +8 more
wiley   +1 more source

Mapping EORTC-QLQ-C30 scores to EQ-5D-5L utility values for gynecological cancer survivors in follow-up care. [PDF]

Qual Life Res
Åbyholm T, Vistad I, Berntsen S, Wisløff T.   +3 more
europepmc   +1 more source

Reduction of Intestinal Redox Potential by Coated Ferulic Acid Accelerates Microbial Restoration and Restricts Enterotoxigenic Escherichia coli Colonization in Weaned Piglets

Animal Research and One Health, EarlyView.
Schematic illustration showing the distinct microbe–host crosstalk patterns shaped by intestinal redox potential. The orange‐blue gradient indicated the redox potential transition from a low to a high potential microenvironment. Under low redox potential, Lactobacillus, Ligilactobacillus, Lachnospira, Roseburia, and Lachnoclostridium promoted ...
Ni Feng, Xin Guo, Changsong Fu, Weiyun Zhu, Yong Su   +4 more
wiley   +1 more source

Integrated Full-Length Transcriptomics, RNA-Seq and Peptidomics Define an Isoform-Resolved Skin Defense Repertoire in the Chinese Spiny Frog (<i>Quasipaa spinosa</i>). [PDF]

Biology (Basel)
Chen J, Feng Y, Qian X, Lin Z.
europepmc   +1 more source