Results 171 to 180 of about 80,997 (253)

Human Monocytic Models Reveal Genotype‐Dependent Inflammatory Programs in VEXAS Syndrome

Arthritis &Rheumatology, EarlyView.
Objective VEXAS syndrome is a severe X‐linked autoinflammatory disorder caused by somatic mutations in ubiquitin‐like modifier activating enzyme 1 (UBA1), with clinical outcomes that vary by UBA1 genotype. We aimed to elucidate genotype‐specific inflammatory programs and identify potential therapeutic targets.
Kana Higashitani, Tatsuma Ban, Yohei Kirino, Go R. Sato, Soichiro Adachi, Yuki Iizuka, Kayo Harita, Ayaka Maeda, Osamu Ohara, Hideaki Nakajima, Tomohiko Tamura   +10 more
wiley   +1 more source

Operationalizing BioSSbD: A safe‐and‐sustainable‐by‐design framework for biorefineries

Biofuels, Bioproducts and Biorefining, EarlyView.
Abstract Biorefineries are central to the transition toward a circular bioeconomy; however, their increasing scale and technological heterogeneity, and the integration of biological, chemical, and thermochemical processes introduce complex challenges related to safety, sustainability, and operational reliability. Existing Safe‐and‐Sustainable‐by‐Design
Fernando Ramonet
wiley   +1 more source

Hybrid frame-mask fixation for Gamma Knife radiosurgery of an extracranial vagal schwannoma: illustrative case. [PDF]

J Neurosurg Case Lessons
Goulenko V, Sinha S, Madhugiri VS, Almeida ND, Malhotra H, Ramdulari AV, Plunkett RJ, Fabiano AJ, Prasad D.   +8 more
europepmc   +1 more source

Dose‐related propofol resistance in COVID‐19 patients: Altered drug plasma levels, mechanistic insights from neuronal‐derived extracellular vesicles and miRNA analysis

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aim Critical care for COVID‐19 patients presents unique challenges, particularly in sedation management. Patients demonstrate notable dose‐related resistance to propofol, potentially due to complex pharmacokinetic alterations. Emerging evidence suggests that plasma extracellular vesicle‐associated miRNA represents valuable predictive ...
Debora Curci, Carlotta Bidoli, Marco Gerdol, Charisse Winston, Robert A. Rissman, Giuliana Decorti, Antonella Fabretto, Andrea Taddio, Gabriele Stocco, Erik Roman‐Pognuz, Marianna Lucafò   +10 more
wiley   +1 more source

Secure image exchange over cloud networks with neural key exchange protocol. [PDF]

Sci Rep
Alexan W, Megalli Y, Malak M, Khaled S, Mashaly M.   +4 more
europepmc   +1 more source

An Integrated Three‐Phase Green Quality Function Deployment Framework for Evaluating Lean–Green Criteria Under Uncertainty

Business Strategy and the Environment, EarlyView.
ABSTRACT Manufacturers need decision models that translate environmental and customer requirements into operational priorities while integrating lean and green practices within a unified programme. This study develops and applies an integrated decision framework to identify, structure and prioritise lean–green manufacturing criteria and to examine how ...
Soroush Avakh Darestani, Rana Imannezhad, Jose Arturo Garza‐Reyes, Jiju Antony, Ambisisi Ambituuni, Ramina Taherkhani, Niloufar Hojat Shemami   +6 more
wiley   +1 more source

Immune Checkpoint Blockade Sensitivity Is Linked to Endogenous Retroelement Transcriptional Changes in Cancer. [PDF]

Cancer Immunol Res
Herrera M, Marhon SA, Liu ZA, Loo H, Abbas-Aghababazadeh F, Bruce JP, Chen D, Van de Laar E, Chow H, Bedard PL, Abdul Razak AR, Spreafico A, Butler MO, Lheureux S, Pugh TJ, Haibe-Kains B, Siu LL, De Carvalho DD, Spiliopoulou P.   +18 more
europepmc   +1 more source

Design of Solar Energy Harvesting Reactor From 2D to 3D Structures for Solar Thermal Conversion

Carbon Innovation, EarlyView.
ABSTRACT Solar energy utilisation is pivotal for advancing sustainable and renewable energy solutions, yet the rational design of high‐efficiency photothermal conversion devices remains a critical challenge. This paper systematically examines the evolution of photothermal reactor architectures from two‐dimensional (2D) to 3D structures, emphasising ...
Haozhe Zhuang, Runsen Wang, Yuxuan Meng, Yuejun Chen, Sanli Tang, Yuefei Ruan, Vellaisamy A. L. Roy, Meng Lin, Xianguang Meng   +8 more
wiley   +1 more source

SerRS2 Identifies an Inflamed-Exhausted Hepatocellular Carcinoma Phenotype with Enhanced DNA-Sensing and Increased Anti-PD-1 Responsiveness. [PDF]

J Inflamm Res
Li P, Zhu G, Li D, Liang M, Zhang L, Li J, Jia Y, Zou B.   +7 more
europepmc   +1 more source

Isoform Specificity of a Compound Targeting Actin Filaments Containing Tropomyosin Tpm1.8/1.9

Cytoskeleton, EarlyView.
ABSTRACT The unbranched actin filaments in mammalian cells are usually composed of co‐polymers of a specific tropomyosin isoform with actin. Genetic manipulation has revealed that the tropomyosins largely define the functional properties of actin filaments in an isoform‐specific, non‐redundant manner.
Jeff Hook, Edna C. Hardeman, Peter W. Gunning   +2 more
wiley   +1 more source