Results 111 to 120 of about 181,991 (355)
Oxidative damage and autophagy in the human trabecular meshwork as related with ageing.
PLoS ONE, 2014 Autophagy is an intracellular lysosomal degradation process induced under stress conditions. Autophagy also plays a major role in ocular patho-physiology. Molecular aging does occur in the trabecular meshwork, the main regulator of aqueous humor outflow,
Alessandra Pulliero +5 more
doaj +1 more source
Advanced Science, EarlyView.ABSTRACT Advancements in tissue engineering have revolutionized therapeutic paradigms for diabetic tissue defects; however, the lack of applicable scaffold containing various bioactive substance aggregates remained a critical bottleneck hindering satisfactory repair effect.
Tao Wang +8 more
wiley +1 more source
Development‐based In Vivo Bioreactor Strategy for Challenging Senescent Bone Reconstruction
Advanced Science, EarlyView.We present a development‐based in vivo bioreactor strategy to generate rejuvenated bone grafts (vBR‐Bone) within aged hosts. By enclosing vBR‐Bone fragments within an asymmetric biomimetic periosteum, segmental femoral defects in aged mice were successfully repaired within 6 weeks. Mechanistically, the multifactors of vBR‐Bone reconstitute a remodeling
Wenchao Zhang +9 more
wiley +1 more source
Advanced Science, EarlyView.A dual‐network bFGF@CB‐gel integrates: i) ChSMA scaffold (mechanical support/BMSCs delivery); ii) BC carrier (sustained bFGF release via EGFL/Itga2b and COMP/PI3K/AKT for adhesion/osteogenesis); iii) bFGF/PI3K/AKT/eNOS for angiogenesis. This rational, synergistic design addresses CSD bone regeneration challenges.
Yunze Feng +12 more
wiley +1 more source
Frontiers in EndocrinologyPurposeTo determine whether there are alterations in marrow fat content in individuals first-time diagnosed with type 1 diabetes mellitus (T1DM) and to explore the associations between marrow fat fraction and MRI-based findings in trabecular bone ...
Wei Li +4 more
doaj +1 more source
Trabecular microcalli in lumbar vertebrae of adult men with alcohol-associated liver disease: Postmortem micro-computed tomography assessment [PDF]
Srpski Arhiv za Celokupno LekarstvoIntroduction/Objective. Increased fracture risk was previously associated with alcohol-associated liver disease (AALD), but contemporary literature lacks the assessment of the micro-fracture healing events (microcalli) in these individuals.
Anđelić Uroš +5 more
doaj +1 more source
High-Speed Cutting of Synthetic Trabecular Bone– A Combined Experimental-Computational Investigation
, 2021 Macdarragh O'Neill, Ted J. Vaughan
openalex +2 more sources
Changes of Radiographic Trabecular Bone Density and Peri-Implant Marginal Bone Vertical Dimensions Around Non-Submerged Dental Implants with a Laser-Microtextured Collar after 5 Years of Functional Loading. [PDF]
, 2020 Renzo Guarnieri +5 more
openalex +1 more source
Alzheimer's Disease Risk Factor APOE4 Exerts Dimorphic Effects on Female Bone
Advanced Science, EarlyView.In aging bone, osteocytes accumulate neurodegenerative risk factor Apolipoprotein E (APOE). A humanized version of the Alzheimer's disease risk allele APOE4 altered the mouse bone transcriptome and proteome, with effects in female bone surpassing the brain, including bone fragility due to suppressed osteocytic maintenance of bone quality, identifying ...
Charles A. Schurman +15 more
wiley +1 more source