Results 91 to 100 of about 1,805,553 (348)

A 3D Bioprinted Spheroid‐Laden dECM‐Enriched Osteosarcoma Model for Enhanced Drug Testing and Therapeutic Discovery

Advanced Healthcare Materials, EarlyView.
A 3D biomimetic OS model was developed by bioprinting an OS‐cell‐derived dECM‐enriched bioink with OS spheroids incorporated. The model showed upregulation of known OS prognostic markers and increased resistance to doxorubicin, compared to 2D cultures and scaffold‐free spheroids, making this a more clinically relevant platform for drug discovery ...
Margarida F. Domingues, Maria Catarina Carreira, Mafalda S. Santos, Daniela Pacheco, Frederico Castelo Ferreira, Paola Sanjuan‐Alberte, João Carlos Silva   +6 more
wiley   +1 more source

Mechanical properties of femoral trabecular bone in dogs

BioMedical Engineering OnLine, 2005
Background Studying mechanical properties of canine trabecular bone is important for a better understanding of fracture mechanics or bone disorders and is also needed for numerical simulation of canine femora.
Nolte Ingo, Behrens Bernd-Arno, Meyer-Lindenberg Andrea, Vogt Ute, Bouguecha Anas, Pressel Thomas, Windhagen Henning   +6 more
doaj   +1 more source

Preventative ibandronate treatment has the most beneficial effect on the microstructure of bone in experimental tumor osteolysis [PDF]

, 2018
We investigated the effect of ibandronate on three-dimensional (3-D) microstructure and bone mass in experimentally induced tumor osteolysis. Walker carcinosarcoma cells were implanted into the left femur of female rats that received 26-day ibandronate ...
Bauss, Frieder, Hayes, Wilson C., Kim, Soo-Zin, Kurth, Andreas A., Müller, Ralph, Shea, Marie   +5 more
core  

Assessment of trabecular bone score (TBS) in overweight/obese men: effect of metabolic and anthropometric factors [PDF]

, 2016
The "trabecular bone score" (TBS) indirectly explores bone quality, independently of bone mineral density (BMD). We investigated the effects of anthropometric and metabolic parameters on TBS in 87 overweight/obese men. We assessed BMD and TBS by DXA, and
Carnevale, Vincenzo, COSTANTINI, DANIELA, GNESSI, Lucio, LENZI, Andrea, LUBRANO, Carla, Migliaccio, Silvia, MORANO, Susanna, Nieddu, Luciano, Romagnoli, Elisabetta   +8 more
core   +1 more source

Additively manufactured 3D porous Ti-6Al-4V constructs mimic trabecular bone structure and regulate osteoblast proliferation, differentiation and local factor production in a porosity and surface roughness dependent manner

Biofabrication, 2014
Additive manufacturing by laser sintering is able to produce high resolution metal constructs for orthopedic and dental implants. In this study, we used a human trabecular bone template to design and manufacture Ti-6Al-4V constructs with varying porosity
A. Cheng, Aiza Humayun, D. Cohen, B. Boyan, Z. Schwartz   +4 more
semanticscholar   +1 more source

SiO2‐CaOCME/Poly(Tetrahydrofuran)/Poly(Caprolactone) 3D‐Printed Scaffolds Drive Human‐Bone Marrow Stromal Cell Osteogenic Differentiation

Advanced Healthcare Materials, EarlyView.
3D printed hybrid scaffolds combining bioactive silica–calcium chemistry with elastic polymers guide human bone stem cells to form bone. The scaffolds support cell survival, organization, and invasion while releasing osteogenic ions. Together, architecture and composition drive bone‐specific gene expression, extracellular matrix organization, and ...
David R. Sory, Agathe C.M. Heyraud, Julian R. Jones, Sara M. Rankin   +3 more
wiley   +1 more source

Relative Contribution of Trabecular and Cortical Bone to Primary Implant Stability: An In vitro Model Study

Journal of Pharmacy and Bioallied Sciences
Background: Primary implant stability is a crucial factor for the successful osseointegration and long-term success of dental implants. The contribution of trabecular and cortical bone to primary implant stability is not well understood.
Trinanjali Bera, Bhavna Jha Kukreja, Chetan Sharma, Vivek V. Gupta, Priya Patel, Parul Singhal, Manish S. Jadhav, Naina Pattnaik   +7 more
doaj   +1 more source

Efeitos sítio-ósseo dependentes no fêmur e vértebra de ratas com disfunções tireoidianas Bone site-dependent effects on femur and vertebrae of female rats with thyroid dysfunctions

Acta Ortopédica Brasileira, 2010
OBJETIVO: Avaliar as diferenças sítio-ósseo dependentes no efeito das disfunções tireoidianas no fêmur e vértebras lombares de ratas. MÉTODOS: 33 ratas Wistar com dois meses de idade foram distribuídas em três grupos: eutireoideas (controle ...
Jankerle Neves Boeloni, Juneo Freitas Silva, Flávia do Carmo Magalhães, Alfredo Miranda Goes, Rogéria Serakides   +4 more
doaj   +1 more source

Iron-enriched diet contributes to early onset of osteoporotic phenotype in a mouse model of hereditary hemochromatosis [PDF]

, 2018
Osteoporosis is associated with chronic iron overload secondary to hereditary hemochromatosis (HH), but the causative mechanisms are incompletely understood.
Camacho, António, Cancela, M. Leonor, Cohen-Solal, Martine, Hang Korng, Ea, Ostertag, Agnès, Pinto, I. Jorge, Porto, Graça, Simão, Márcio   +7 more
core   +4 more sources

Gentamicin‐Loaded Carbonate Apatite with Dual Antibacterial and Osteogenic Functions for Combating Surgical Site Infections

Advanced Healthcare Materials, EarlyView.
A bone substitute with gentamicin physically precipitated onto the surface of carbonate apatite exhibits prompt drug release, high bactericidal activity, and osteogenic capacity. Efficient antibacterial activity mitigates early postoperative neutrophil accumulation, the status of which may serve as a potential parameter for evaluating the antibacterial
Linghao Xiao, Gabriela Laranjeira Abe, Jun‐Ichi Sasaki, Haruaki Kitagawa, Ririko Tsuboi, Tomoki Kohno, Satoshi Imazato   +6 more
wiley   +1 more source