Results 161 to 170 of about 157,325 (288)

Hypoxia Exacerbates Periapical Periodontitis‐Associated Pathological Bone Loss via the Hypoxia‐Inducible Factor‐2α‐Calmodulin‐Dependent Protein Kinase IV Axis

Cell Proliferation, EarlyView.
Hypoxia exposure activates HIF‐2α, which binds to the Camk4 promoter to enhance RANKL‐mediated osteoclast differentiation, leading to aggravated alveolar bone resorption in periapical periodontitis. ABSTRACT Periapical periodontitis is one of the most common inflammatory bone destructive diseases. Epidemiological evidence suggests that hypoxia exposure,
Kang Gao, Yifan Xu, Haoran Du, Zixiao Li, Xiaochen Fang, Minghui Wang, Jia Liu, Xu Zha, Xianglong Han, Weihua Guo, Xicheng Liu, Jian Zhou   +11 more
wiley   +1 more source

Disproportionate Decline in Trabecular Bone Score Compared to Bone Mineral Density in Southeast Asian Patients with Thalassemia: A Matched Control Study. [PDF]

Calcif Tissue Int
Pongchaiyakul C, Teawtrakul N, Theerakulpisut D, Sribenjalak D, Charoenngam N.   +4 more
europepmc   +1 more source

Unexpected Promotion of Bone Regeneration by Inhibition of BMPR1A‐Mediated BMP Signalling

Cell Proliferation, EarlyView.
BMPR1A downregulation reduces ID1, releases TCF3 to activate GNG4‐PI3K‐AKT signalling, thereby promoting OPC proliferation and bone regeneration. ABSTRACT Bone morphogenetic protein (BMP) signalling plays a pivotal role in bone regeneration by regulating osteoprogenitor cell (OPC) function, and BMPs have been widely used in clinical treatment. However,
Zihao Zhou, Yun Zhai, Xiaochen Liu, Jiaojiao Shao, Jiani Zhou, Zhaoyang Li, Jiale He, Shuxian Lin, Qi Zhang   +8 more
wiley   +1 more source

Clinical Utility of Trabecular Bone Score in Gastroenterology: A Narrative Review. [PDF]

Biomedicines
Olic I, Zivkovic PM, Hadjina IT, Zaja I.
europepmc   +1 more source

CKAP4 Regulates ERS‐Induced Apoptosis in Osteoclasts Through FOXO3 in Periodontitis

Cell Proliferation, EarlyView.
CKAP4 promotes the transcription of PERK via FOXO3 in OCs, thereby facilitating ER stress‐induced apoptosis. In periodontitis, the reduction of CKAP4 in OCs leads to decreased OC apoptosis, which exacerbates alveolar bone resorption. ABSTRACT Periodontitis is a prevalent oral disease characterised by chronic inflammation and irreversible alveolar bone ...
Jiayu Cheng, Dihao Tao, Wenzhe Wang, Huiyu Wang, Hanzhe Wang, Yufan Liang, Jia Guo, Wenhao Liu, Yiming Wang, Jianhua Yang, Xiaoning He, Ce Shan, Bei Li   +12 more
wiley   +1 more source

Contribution of Trabecular Bone Score to Fracture Risk Stratification Beyond Bone Mineral Density in Women with Rheumatoid Arthritis: Results from a Cross-Sectional Cohort. [PDF]

Mediterr J Rheumatol
Ismaili A, Chbihi A, Chergaoui I, Kherrab A, Ghazi M, Bouchti IE, Niamane R.   +6 more
europepmc   +1 more source

Collagen Type VI Alpha 1 as a Regulator of Redox Homeostasis in Antioxidant‐Enhanced Osteogenesis of Dental Stem Cells

Cell Proliferation, EarlyView.
Under physiological conditions, NAC activates the PI3K‐AKT‐COL6A1 axis to sustain redox balance and enhance osteogenesis. COL6A1 deficiency, however, compromises this axis, inducing oxidative stress and impairing NAC's osteogenic efficacy. ABSTRACT Alveolar bone injury represents a prevalent clinical challenge in dentistry, for which stem cell‐based ...
Zhaosong Meng, Jiacheng Liu, Yue Zhang, Ruimeng Yang, Jingyi Zhang, Haosun Yang, Zheng Wang, Ran Wei, Zhe Li, Shuling Guo, Lizhi Hu, Lei Sui   +11 more
wiley   +1 more source

Beyond DXA: Trabecular Bone Score, Quantitative Ultrasound and Bone Turnover Markers for Morphometric Vertebral Fracture Assessment in People Living with HIV. [PDF]

Diagnostics (Basel)
Razvan DV, Rosca O, Bogdan IG, Stanga L, Laitin SMD, Vlad A.   +5 more
europepmc   +1 more source

Tunnelling Nanotube‐Mediated Lysosome Sharing Promotes Osteocyte Survival via Transcellular Autophagy

Cell Proliferation, EarlyView.
This study provides the first definitive identification of tunnelling nanotubes (TNTs) between cultured osteocytes and shows TNT‐mediated lysosome transfer from healthy to stressed cells, restoring autophagic flux and preventing apoptosis. This discovery of transcellular autophagy reveals a new survival mechanism in osteocytes, offering potential ...
Jinbiao Qiang, Ronghao Jin, Tong Sha, Fang Zheng, Yijun Zhou, Yue Hu, Shuyu Zhang, Zhenming Yang, Mengdong Nie, Huanyu Luo, Xiaoduo Tang, Hao Guo, Zunxuan Xie, Jinwei Li, Hongchen Sun, Cangwei Liu, Ce Shi   +16 more
wiley   +1 more source

Which One Can Detect More Osteopenia and Osteoporosis in Rheumatoid Arthritis Patient? Dual-Energy X-Ray Absorptiometry (DXA) or Trabecular Bone Score (TBS). [PDF]

Int J Prev Med
Monjezi D, Shojaie B, Salesi M.
europepmc   +1 more source