Results 171 to 180 of about 157,325 (288)

YTHDF3 Enhances Osteogenic Differentiation of Bone Marrow Mesenchymal Stem Cells in Osteoporosis by Promoting TBX19 Expression

Cell Proliferation, EarlyView.
In this study, OP‐BMSCs were successfully isolated from OVX osteoporotic rats. Mechanistic investigations revealed that the RNA‐binding protein YTHDF3 significantly upregulates Tbx19 expression by enhancing the stability of Tbx19 mRNA. Elevated Tbx19 levels, in turn, activate key osteogenic molecules, effectively promoting the differentiation of OP ...
Qianke Tao, Qiaonan Ye, Chengpeng Yang, Yuping Xie, Xuemei Long, Long Bai, Zhiyuan Zhang, Qianwei Li, Dan Tan, Jingang Xiao   +9 more
wiley   +1 more source

Soluble Epoxide Hydrolase Inhibition Regulates Septoclast Activity to Promote Long Bone Growth and Fracture Healing by Enhancing Endothelial‐to‐Mesenchymal Notch Signalling

Cell Proliferation, EarlyView.
The sEH inhibitor TPPU upregulates endothelial HIF‐1α, activating the NOTCH signalling pathway between endothelial cells and mesenchymal stem cells. This promotes the differentiation and formation of FABP5+ septoclasts, enhances their participation in endochondral ossification, and ultimately improves longitudinal bone growth and fracture healing ...
Weixian Chen, Liangliang Liu, Xumeng Wang, Juanjuan Li, Jingyi Zhang, Xiaoli Shi, Qing Sun, Xu Chang, Jing Zhang, Jie Zhao, Fu Wang   +10 more
wiley   +1 more source

Fracture risk assessment in patients with ileal urinary diversion after radical cystectomy: a comprehensive evaluation integrating bone mineral density, trabecular bone score, and FRAX®. [PDF]

Arch Osteoporos
Domínguez A, Casado E, Muñoz-Rodríguez J, Prats J, Grubicy ML, Masip N, Piqué C, Centeno C, Bonfill T, Fuertes D, Serra-Aracil X.   +10 more
europepmc   +1 more source

Hypercortisolism: Causes, Consequences and Clinical Significance – A Review of Pathophysiology

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Hypercortisolism or Cushing syndrome is a heterogeneous clinical spectrum caused by chronic glucocorticoid excess, ranging from exogenous Cushing syndrome to rare endogenous aetiologies and the increasingly recognised entity of mild autonomous cortisol secretion (MACS). Physiological cortisol production is tightly regulated by the hypothalamic–
Mohamed Eldib, Francisco Emilio Fierro, Maria Ortega Abad, Ricardo Correa   +3 more
wiley   +1 more source

Bone Mineral Density and Trabecular Bone Score in Children, Adolescents and Young Adults with Familial Dysautonomia. [PDF]

Calcif Tissue Int
Bar-Aluma BE, Porges R, Tripto-Shkolnik L, Keler S, Gruber N, Dagan A, Modan-Moses D, Levy-Shraga Y.   +7 more
europepmc   +1 more source

Biomechanical Analysis of 3D Printed and Thermoformed EVA Custom‐Made Mouthguard: Experimental and Finite Element Analyses

Dental Traumatology, EarlyView.
ABSTRACT Background/Objective 3D printed materials have been evaluated for fabricating mouthguards; however, little is known about their biomechanical performance in preventing dental trauma. This study aimed to compare two 3D printed polymers and three ethylene vinyl acetate (EVA) sheets used for mouthguard fabrication regarding their mechanical ...
Airin Karelys Avendaño Rondon, Izabela Batista Cordeiro, Maribí Isomar Terán Lozada, Gustavo Mendonça, Priscilla Barbosa Ferreira Soares, Paulo Sergio Borella, Carlos José Soares   +6 more
wiley   +1 more source

High prevalence and underdiagnosis of osteoporosis in total hip arthroplasty candidates: a comprehensive assessment using bone mineral density, trabecular bone score, and bone turnover markers. [PDF]

J Orthop Surg Res
Ueki S, Shoji T, Yamasaki T, Morita H, Kozuma Y, Nakayama N, Adachi N.   +6 more
europepmc   +1 more source

Dens Invaginatus as a Biomechanical Risk Modifier in Dental Trauma: Finite Element Analysis

Dental Traumatology, EarlyView.
ABSTRACT Introduction/Aims Traumatic dental injuries are common in childhood and may adversely affect functional and psychosocial well‐being. Dens invaginatus, a developmental anomaly caused by the infolding of the enamel organ during odontogenesis, alters tooth morphology and may influence biomechanical behavior under traumatic loading.
Emine Şuranur Ayaz, Sema Aydınoğlu, Dilara Nil Günaçar, Ayberk Dizdar, Ecren Uzun Yaylaci, Murat Yaylaci, Mukaddes Yerebakan   +6 more
wiley   +1 more source

Proton pump inhibitor exposure, trabecular bone score, and BMD: a registry-based cohort study. [PDF]

J Bone Miner Res
Zarzour F, Schousboe JT, Binkley N, Hans D, Leslie WD.   +4 more
europepmc   +1 more source

Effect of aging on healing of mandibular tooth extraction socket in a rat model

European Journal of Oral Sciences, EarlyView.
Abstract This study evaluated the effect of aging on bone regeneration in mandibular extraction sockets. Male Sprague–Dawley rats were divided into three age groups: 2‐month‐old (2 M, n = 6), 10‐month‐old (10 M, n = 6), and 18‐month‐old (18 M, n = 5). Two weeks post‐extraction, comprehensive analyses were performed using micro‐computed tomography (µ‐CT)
Kyung Su Shin, Han Wool Kwak, Jong‐Seong Chae, Si‐On Choi, Suah Han, Hwa Young Yu, Dae Ho Leem, Hyun Seok   +7 more
wiley   +1 more source