Results 221 to 230 of about 78,864 (334)

Slo1 Deficient Myoblast Exosomes‐Derived miR‐222‐3p Inhibits Osteogenic Differentiation via Targeting of STAT3

Journal of Cachexia, Sarcopenia and Muscle, Volume 16, Issue 6, December 2025.
ABSTRACT Background Previous research has shown that the conditional knockout of Slo1 in muscle leads to a reduction in muscle strength and inhibits myogenic differentiation. Exosomes are emerging as necessary mediators of the crosstalk between muscle and bones.
Yonghui Wang, Xinrun Ma, Yang Chen, Chao Xia, Xue Lei, Junran Liu, Yunyi Jiang, Rang Xu, Yanhong Gao   +8 more
wiley   +1 more source

Elastic Modulus Determination of Normal and Glaucomatous Human Trabecular Meshwork [PDF]

, 2011
Julie A. Last, Tingrui Pan, Yuzhe Ding, Christopher M. Reilly, Kate E. Keller, Ted S. Acott, Michael P. Fautsch, Christopher J. Murphy, Paul Russell   +8 more
openalex   +1 more source

Comparative Finite Element Analysis of Denosumab and Bazedoxifene on Pedicle Screw Stability in Osteoporotic Spines

JOR SPINE, Volume 8, Issue 4, December 2025.
The study aims to compare the effects of denosumab and bazedoxifene on spinal instrumentation surgery. CT scans obtained before and after treatment were used to generate 3D vertebral models for in silico biomechanical analysis, and mechanical loading directions—including compression and multidirectional screw forces—were applied to assess implant ...
Tomoyuki Asada, Soji Tani, Tomoko Towatari, Mahoko Ishikawa, Philip Varnadore, Yoshifumi Kudo, Peter G. Passias, Benjamin A. Alman, Koji Ishikawa   +8 more
wiley   +1 more source

2D Boron Nanoplatelets as a Multifunctional Additive for Osteogenic, Gram‐Negative Antimicrobial and Mechanically Reinforcing Bone Repair Scaffolds

Small Science, Volume 5, Issue 12, December 2025.
An ideal bone scaffold will enhance osteogenesis, angiogenesis, and neurogenesis, while preventing inflammation, infection, and stiffness mismatch. 2D materials unlock diverse properties arising from the nanoplatelet morphology, while simultaneously leveraging intrinsic material properties .
Jack Maughan, Harneet Kaur, Lucy Prendeville, Tian Carey, Cian O’Connor, Kevin Synnatschke, Juan Carlos Palomeque, Ian Woods, Fergal J. O’Brien, Jonathan N. Coleman   +9 more
wiley   +1 more source

Mechanism of EC‐EXOs‐Derived THBS3 Targeting CD47 to Regulate BMSCs Differentiation to Ameliorate Bone Loss

Cell Proliferation, Volume 58, Issue 12, December 2025.
EC‐EXOs could regulate the differentiation of BMSCs through the key protein THBS3, which inhibits their differentiation to lipogenic cells and promotes their differentiation to osteoblasts. THBS3 could down‐regulate the expression of its downstream target CD47 and delay the process of bone loss in aged mice and OVX mice, which may provide a novel ...
Jiaojiao Wang, Zhaokai Zhou, Wenjie Chen, Yun Chen, Qiyue Zheng, Yajun Chen, Zhengxiao Ouyang, Ran Xu, Qiong Lu   +8 more
wiley   +1 more source

Transcriptome Profiling of Trabecular Meshwork Progenitor Cells. [PDF]

Stem Cell Rev Rep
Fan X, Kennedy S, Bilir EK, Lane B, Kingston OA, Chen X, Kearns VR, Willoughby CE, Sheridan CM.   +8 more
europepmc   +1 more source

Switch from BAK-preserved to preservative-free latanoprost decreases anterior chamber flare in POAG patients [PDF]

, 2019
De Bacquer, Dirk, Kestelyn, Philippe, KESTELYN, PHILIPPE ADRIAAN, Stevens, AM   +3 more
core   +2 more sources

Stem Cells from Human Trabecular Meshwork Hold the Potential to Develop into Ocular and Non-Ocular Lineages After Long-Term Storage

, 2019
Ajay Kumar, Yi Xu, Yiqin Du
openalex   +2 more sources

AAV Gene Therapy Drug Development and Translation of Engineered Ocular and Neurotropic Capsids: A Systematic Review Using Natural Language Processing

Clinical and Translational Science, Volume 18, Issue 12, December 2025.
ABSTRACT Natural AAV serotypes often lack specificity and efficiency, leading to off‐target effects and a low therapeutic index. To overcome these limitations of naturally occurring serotypes, there has been a keen interest in the field to engineer novel capsids to enhance tissue and cell‐specific targeting, resulting in a high number of published ...
Chinaza Agbim, Heng‐Yi Wu, Chloe Kim, Elizabeth Mutter‐Rottmayer, Shraddha Sadekar, Milica Markovic   +5 more
wiley   +1 more source

Identification and validation of oxidative stress signature genes in the trabecular meshwork of glaucoma. [PDF]

Sci Rep
Xu W, Zhang F, Huang J.
europepmc   +1 more source