Results 51 to 60 of about 16,541 (253)

An Iconic Case of Pigmentary Glaucoma: Brief Review of the Literature

Case Reports in Ophthalmology, 2020
Pigment dispersion syndrome and pigmentary glaucoma are two conditions characterized by pigment dispersion originating from the posterior part of the iris and its accumulation on the trabecular meshwork, corneal endothelium, and anterior surface of the ...
Mariachiara Di Pippo, Chiara Ciancimino, Luca Scuderi, Andrea Perdicchi   +3 more
doaj   +1 more source

Multi‐Enzyme Mimetic Molybdenum Nitride Nanozymes Reshape Subgingival Microenvironment for Synergistic Periodontitis Therapy via ROS Regulation and Microbiome Remodeling

Advanced Science, EarlyView.
ABSTRACT Periodontitis, a chronic inflammatory disease initiated and sustained by plaque microorganisms and host immune response, remains an intractable oral disease and a leading cause of tooth loss worldwide. Traditional mechanical debridement and adjunctive antibiotic or antiseptic therapy often shows limited efficacy due to the complex anatomical ...
Weiyu Zhang, Zhongwei Yang, Yunfan Zhang, Longwei Wang, Xiaoyu Zhang, Jiahui Mao, Yizhi Dai, Yifan Yuan, Mingge Wang, Xin Yang, Xin Yu, Jing Liu, Chunying Chen   +12 more
wiley   +1 more source

Senolytic Therapy as a Preventive Strategy for Spine Degeneration and Pain

Advanced Science, EarlyView.
Cellular senescence promotes inflammation, tissue degeneration, and chronic back pain. In sparc‐null mice, early oral administration of the senolytic agents o‐vanillin and RG‐7112 reduced senescent cell burden and pro‐inflammatory SASP signaling across intervertebral discs, endplates, vertebral bone, and spinal cord.
Saber Ghazizadeh, Hosni Cherif, Matthew Mannarino, Juiena Sagir, Magali Millecamps, Jean A. Ouellet, Laura S. Stone, Lisbet Haglund   +7 more
wiley   +1 more source

The accumulation of CD11b+ inflammatory cells in the trabecular meshwork.

, 2013
The representative immunohistochemically stained images showed the accumulation of CD11b+ inflammatory cells (labeled green; DAPI staining to locate cell nucleus) in the trabecular meshwork following particle injection (A).
Ashwin Nair (337412), Hong Weng (337413), Zhibing Hu (337414), Ling Zou (185293), Liping Tang (77094), Yi-Ting Tsai (309320)   +5 more
core   +1 more source

Harnessing Phase Separation for the Development of High‐Performance Hydrogels

Advanced Science, EarlyView.
ABSTRACT Hydrogels are indispensable for the development of next‐generation bioelectronics, soft robotics, and biomedical devices, where their mechanical properties determine performance and reliability. Among strategies to enhance hydrogel mechanics, phase separation enables controlled heterogeneity resulting in gel networks that are reinforced by ...
Yue Shao, Yiming Ma, Baihao Shao, Molly M. Stevens   +3 more
wiley   +1 more source

Isolated anterior-chamber fungal flocculosus in a healthy child with seeding through the trabecular meshwork

TNOA Journal of Ophthalmic Science and Research, 2019
We report a case of isolated anterior-chamber (AC) fungal hyphae in a healthy child following injury with a broomstick with no evidence of obvious intraocular penetration, a rare presentation of isolated traumatic AC mycoses.
Manjula Jayakumar, Akshaya Parthasarathy
doaj   +1 more source

Intraocular pressure changes: an important determinant of the biocompatibility of intravitreous implants. [PDF]

PLoS ONE, 2011
In recent years, research efforts exploring the possibility of using biomaterial nanoparticles for intravitreous drug delivery has increased significantly. However, little is known about the effect of material properties on intravitreous tissue responses.
Ling Zou, Ashwin Nair, Hong Weng, Yi-Ting Tsai, Zhibing Hu, Liping Tang   +5 more
doaj   +1 more source

High‐Performance Prevascularized SHED‐Laden rGO@Hydrogel Achieves Optimized Diabetic Bone Defect Repair

Advanced Science, EarlyView.
A high‐performance 3D scaffold integrating rGO and SHEDs is developed to overcome impaired healing in diabetic bone defects. By driving extracellular matrix remodeling, rGO creates a pro‐angiogenic niche that significantly accelerates in vitro vascular network formation.
Can Zhang, Yiyuan Kang, Shulin Lai, Chunyi Wang, Guixin He, Kehui Jian, Suhan Yin, Xiner Tan, Xinru Zhou, Wenjing Liu, Fujian Zhao, Jia Liu, Longquan Shao   +12 more
wiley   +1 more source

Assessment of Transport of Lipid Metabolites Within Trabecular Meshwork Cells

, 2019
Lipids from trabecular meshwork (TM) cells are of particular interest to ophthalmological researchers as a therapeutic target for lowering intraocular pressure (IOP) in glaucomatous eyes.
Alfonso, Bryan, Dancausse, Stephanie, Kalahasty, Karthik, Bhattacharya, Sanjoy K, Toglia, Daphne   +4 more
core   +1 more source

p38 MAP kinase inhibitor suppresses transforming growth factor-β2-induced type 1 collagen production in trabecular meshwork cells.

PLoS ONE, 2015
Glaucoma is an age-related neurodegenerative disease of retinal ganglion cells, and appropriate turnover of the extracellular matrix in the trabecular meshwork is important in its pathology. Here, we report the effects of Rho-associated kinase (ROCK) and
Miyuki Inoue-Mochita, Toshihiro Inoue, Tomokazu Fujimoto, Takanori Kameda, Nanako Awai-Kasaoka, Naoki Ohtsu, Kenichi Kimoto, Hidenobu Tanihara   +7 more
doaj   +1 more source