Results 51 to 60 of about 14,535 (168)

Nacre‐inspired layered composite with excellent mechanical support and osteogenic potential for cervical interbody cage

BMEMat, EarlyView.
The cervical interbody cage needs to take both biomechanical and biological requirements into account. Here, a new‐style degradable, multicomponent, and bioinspired nacre‐like cervical interbody cage composite, which exhibits promising mechanical‐support‐related behavior and osteogenesis‐related potential, is designed and prepared.
Xiu‐Wu Guo, Shao‐Meng Wen, Tian‐Yu Xing, Yang Zhou, Chun‐Xin Wang, Chang Ge, Si‐Ming Chen, Wen‐Zhi Zhang, Shu‐Hong Yu   +8 more
wiley   +1 more source

The TGFβ Induced MicroRNAome of the Trabecular Meshwork

Cells
Primary open-angle glaucoma (POAG) is a progressive optic neuropathy with a complex, multifactorial aetiology. Raised intraocular pressure (IOP) is the most important clinically modifiable risk factor for POAG.
Chelsey Doyle, Breedge Callaghan, Anton W. Roodnat, Lee Armstrong, Karen Lester, David A. Simpson, Sarah D. Atkinson, Carl Sheridan, Declan J. McKenna, Colin E. Willoughby   +9 more
doaj   +1 more source

Integrating chemo‐mechanical cues in nano‐microscale environments for stem cell regulation

BMEMat, EarlyView.
Nano/microscale control strategies, including nano/microscale materials, ligand spacings, and cell encapsulating gels, cell mechanics, integrin signaling, and biochemical cues to direct stem cell fate, tissue regeneration, and organoid engineering, enabling advanced biomedical applications through mechanoregulation at cell‐material interfaces ...
Rajendra K. Singh, Varsha Sagar, Amal George Kurian, Shreyas Kumar Jain, Hye Sung Kim, Hae‐Won Kim   +5 more
wiley   +1 more source

Review Of Applied Mathematical Models For Describing The Behaviour Of Aqueous Humor In Eye Structures

International Journal of Applied Mechanics and Engineering, 2015
In the paper, currently used methods for modeling the flow of the aqueous humor through eye structures are presented. Then a computational model based on rheological models of Newtonian and non-Newtonian fluids is proposed. The proposed model may be used
M. Dzierka, P. Jurczak
doaj   +1 more source

Orthodentine‐osteodentine and osteocytic‐anosteocytic transition inferred from Silurian stem chondrichthyan dermal jawbones with ever‐white teeth overgrown by brown denticles

Developmental Dynamics, EarlyView.
Abstract Background The dentigerous jawbones of a 423‐million‐year‐old stem chondrichthyan (ischnacanthid acanthodian) carry a characteristic combination of multi‐row non‐shedding white teeth with brownish overgrowing denticles. The color distinction makes it a good model for observing the interaction between two odontode lineages, but the nature of ...
Jia‐Cih Kang, Henning Blom, Tiiu Märss, Donglei Chen   +3 more
wiley   +1 more source

Integrating ZooMS and taphonomy further highlights differential processing of animal and Neandertal carcasses in the Quina Mousterian at Les Pradelles (Marillac‐le‐Franc, southwest France)

Journal of Quaternary Science, EarlyView.
ABSTRACT The cave of Les Pradelles (Marillac‐le‐Franc, France) was repeatedly visited by Neandertals ~55 000 years ago and is a key site in discussions of Neandertal cannibalism. Excavations between 1967 and 1980 (Vandermeersch) and between 2001 and 2013 (Maureille/Mann) produced a rich faunal assemblage (>20 000 bones), alongside Quina Mousterian ...
Pauline Raymond, Jean‐Jacques Hublin, Karen Ruebens, Geoff M. Smith, Sandrine Costamagno, Cédric Beauval, Alan Mann, Bruno Maureille   +7 more
wiley   +1 more source

Promises and limitations of deep learning for predicting knee osteoarthritis progression from medical imaging: A systematic review

Knee Surgery, Sports Traumatology, Arthroscopy, EarlyView.
Abstract Purpose To systematically evaluate the performance, methodological quality, and translational barriers of deep learning (DL) models for predicting knee osteoarthritis (KOA) progression from medical imaging. Methods Following PRISMA guidelines, we searched PubMed, Scopus, and Web of Science (inception to June 2026) for peer‐reviewed studies ...
Amna Gillani, Rüdiger von Eisenhart‐Rothe, Klaus Woertler, Michael T. Hirschmann, Daniel Rueckert, Florian Hinterwimmer   +5 more
wiley   +1 more source

Navigating the Complexity: A Comprehensive Review of GSK‐3 Inhibition in Regenerative Medicine

Medicinal Research Reviews, EarlyView.
ABSTRACT Glycogen synthase kinase‐3 (GSK‐3) is a central regulator of numerous cellular signaling pathways, with critical roles in metabolism, proliferation, differentiation, and tissue regeneration. This review explores the multifaceted effects of pharmacological GSK‐3 inhibition across multiple body districts, focusing on its highly context‐dependent
Davide Schiroli, Alessia Merra, Chiara Marraccini, Lucia Merolle, Graziella Pellegrini, Eleonora Maurizi   +5 more
wiley   +1 more source

Compensatory Role of Inositol 5-Phosphatase INPP5B to OCRL in Primary Cilia Formation in Oculocerebrorenal Syndrome of Lowe.

PLoS ONE, 2013
Inositol phosphatases are important regulators of cell signaling, polarity, and vesicular trafficking. Mutations in OCRL, an inositol polyphosphate 5-phosphatase, result in Oculocerebrorenal syndrome of Lowe, an X-linked recessive disorder that presents ...
Na Luo, Akhilesh Kumar, Michael Conwell, Robert N Weinreb, Ryan Anderson, Yang Sun   +5 more
doaj   +1 more source

Effect of Mesoporous Bioactive Glass on the Morphology and Thermal Properties of PLA‐Based Biocomposites for Bone Tissue Engineering

Polymer Engineering &Science, EarlyView.
Schematic overview of the preparation and characterization of PLA‐based biocomposites containing mesoporous bioactive glass, highlighting the relationship between particle morphology, composite properties, and their potential for bone regeneration. ABSTRACT The present study proposes the development of a potential biocomposite for bone regeneration by ...
Bruna Segat, Luis Guilherme Silva Rosa, Felippe Migliato Marega, Luiz Antonio Pessan, Lidiane Cristina Costa, Daniela Becker   +5 more
wiley   +1 more source