Results 71 to 80 of about 16,541 (253)

A Periosteum‐Inspired Janus Piezoelectric Scaffold Using Bioenergetic‐Driven H‐Type Vascularization for Diabetic Bone Regeneration

Advanced Science, EarlyView.
A periosteum‐inspired Janus piezoelectric scaffold converts micromechanical forces into electrical signals and synergizes with controlled resveratrol release. This dual action reprograms endothelial metabolism, drives H‑type vessel formation, and restores bone–vessel coupling in diabetic bone defects.
Kai Wang, Kai Jiang
wiley   +1 more source

The Dysfunction of the Trabecular Meshwork During Glaucoma Course

, 2015
Primary open angle glaucoma is a multi-tissue disease that targets, in an ascending order, the trabecular meshwork, the optic nerve head, the lateral geniculate nuclei, and the visual cortex.
Pulliero, Alessandra, Alberto Izzotti, Sergio Claudio Saccà, Alessandra Pulliero, Saccã , Sergio Claudio, Izzotti, Alberto   +5 more
core   +1 more source

Iris Morphological Features in Patients with 360° Angle-Closure Neovascular Glaucoma: An Anterior Segment Optical Coherence Tomography Study

Case Reports in Ophthalmology, 2018
Purpose: To investigate iris morphological features in 360° angle-closure neovascular glaucoma (NVG) by swept-source anterior segment optical coherence tomography (ASOCT).
Yui Kobayashi, Shunsuke Nakakura, Etsuko Terao, Yuki Fujio, Kanae Matsuya, Hitoshi Tabuchi, Yasuhiro Takahashi, Yoshiaki Kiuchi   +7 more
doaj   +1 more source

Hyaluronan synthase in trabecular meshwork cells [PDF]

British Journal of Ophthalmology, 2003
Hyaluronan is present in the trabecular meshwork where it is involved in the pathophysiology of aqueous outflow environment. In this study, the expression and regulation of hyaluronan synthase (HAS), which is the enzyme synthesising hyaluronan, in trabecular meshwork cells were investigated.Cultured bovine trabecular meshwork cells (BTMCs) were used ...
T, Usui, F, Nakajima, R, Ideta, Y, Kaji, Y, Suzuki, M, Araie, S, Miyauchi, P, Heldin, H, Yamashita   +8 more
openaire   +2 more sources

Lesion Site‐Targeted Microspheres Modulate Nav1.7‐Related Signaling for Osteoarthritis Treatment

Advanced Science, EarlyView.
Cartilage‐targeted carbamazepine‐loaded WYRGRL‐modified composite microspheres (CBZ/WCOM) anchor to exposed type II collagen in osteoarthritic lesions and release carbamazepine under acidic conditions. This bind‐then‐release platform modulates Nav1.7‐related sodium signaling, Na⁺/Ca²⁺ exchanger‐associated Ca2+ dynamics, and heat shock protein 70 ...
Cheng Chen, Jiaying Li, Jinjin Ma, Xiaonan Yuan, Yao Xiao, Yang Zhang, Yuan Chen, Hao Jiang, Hui He, Jie Hu, Qianglong Chen, Jinniu Zhang, Bin Li, Yun Zhou, Fengxuan Han, Yong Wang   +15 more
wiley   +1 more source

Glycoconjugates of the human trabecular meshwork: a lectin histochemical study

, 1995
Twelve specimens of resin-embedded human trabecular meshwork were probed with a panel of 21 biotinylated lectins, using an avidin-biotin peroxidase revealing system, in order to determine the normal pattern of saccharide expression in this tissue.
Bonshek, Richard, Mackenzie, K.R., Chapman, S. A., O'Donoghue, E, Jones, Carolyn; id_orcid, McLeod, D, Stoddart, Robert   +6 more
core   +1 more source

Optical Coherence Tomography Observation of Gonio Structures during Microhook Ab Interno Trabeculotomy

Journal of Ophthalmology, 2017
Introduction. Intraoperative observation of ocular structures using microscope-integrated optical coherence tomography (iOCT) has been adopted recently.
Masaki Tanito
doaj   +1 more source

Evidence for a calcification process in the trabecular meshwork [PDF]

Experimental Eye Research, 2009
The human trabecular meshwork (TM) expresses many genes that have been associated with physiological (bone, cartilage, teeth) and pathological (vascular systems, kidney) calcification. In particular, the TM highly expresses the inhibitor of calcification Matrix Gla (MGP) gene, which encodes a vitamin K-dependent protein that requires post-translational
Teresa, Borrás, Núria, Comes
openaire   +2 more sources

ROS‐Targeted Nanomotor Therapy in OA: Cartilage Protection and Pain Relief

Advanced Science, EarlyView.
ROS‐responsive NM@MET nanomotors utilize elevated ROS in osteoarthritic joints to promote deep penetration into cartilage and synovium and enable sustained metformin release. By scavenging ROS, regulating NRF2/KEAP1 signaling, protecting chondrocytes, suppressing synovial inflammation, and attenuating nociceptive signaling, NM@MET alleviates pain and ...
Meng Zheng, Changyu Liu, Qin Xia, Arndt F. Schilling, Jiawei Jiang, Renpeng Peng, Zixing Shu, Tian Ma, Danni Luo, Yaoyu Zhang, Yibo Fan, Xuyuan Zhang, Song Li, Kai Wang, Wentao Ke, Yuan Xiong, Yuanli Zhu, Fangzhi Mou, Jun Xiao, Hao Zhu   +19 more
wiley   +1 more source

Suppression of trabecular meshwork phagocytosis by norepinephrine is associated with nocturnal increase in intraocular pressure in mice

Communications Biology, 2022
Intraocular pressure, which can cause glaucoma, is found to be affected by nocturnal sympathetic noradrenaline, which inhibits phagocytosis in trabecular meshwork cells through β1-aderenergic receptor mediated cAMP-EPAC-SHIP1 activation.
Keisuke Ikegami, Satoru Masubuchi
doaj   +1 more source