Results 81 to 90 of about 67,374 (288)

The trabecular meshwork in acute and chronic angle closure glaucoma.

Indian Journal of Ophthalmology, 2001
PURPOSE: To determine the effect of acute and chronic primary angle closure glaucoma (PACG) on the trabecular meshwork. METHODS: Trabecular specimens of 16 consecutive patients with primary angle closure glaucoma (PACG)--6 acute PACG eyes, and 10 chronic
Sihota R, Lakshmaiah N, Walia K, Sharma S, Pailoor J, Agarwal H   +5 more
doaj  

TIPARP is involved in the regulation of intraocular pressure

Communications Biology, 2022
TIPARP, an inducible poly-ADP-ribose polymerase, is identified as a novel regulator of intraocular pressure through modulation of extracellular matrix and cell cytoskeleton proteins in trabecular meshwork cells.
Youjia Zhang, Maomao Song, Yingwen Bi, Yuan Lei, Xinghuai Sun, Yuhong Chen   +5 more
doaj   +1 more source

Inhibition of Heat Shock Protein 90β by Catalpol: A Potential Therapeutic Approach for Alleviating Inflammation‐Induced Cartilage Injuries in Osteoarthritis

Advanced Science, EarlyView.
The schematic diagram delineates the chondroprotective effects of Ca‐bMSN in OA models. The upper portion of the diagram depicts the synthesis process of Ca‐bMSN. The lower section illustrates the post‐injection of Ca‐bMSN in joint cavity, catalpol released and subsequently mediates the reduction of oxidative stress, ECM catabolism, apoptosis, and ...
Zhenwei Zhou, Binghua Zhang, Lang Liu, Jie Yang, Yuting Wang, Cheng Lv, He Zhang, Yuchi Wei, Zhanliang Jiang, Zeyu Peng, Daqing Zhao, Xiangyang Leng, Xiangyan Li, Hang Su, Haisi Dong   +14 more
wiley   +1 more source

Improving Stem Cell Delivery to the Trabecular Meshwork Using Magnetic Nanoparticles

Scientific Reports, 2018
Glaucoma is a major cause of blindness and is frequently associated with elevated intraocular pressure. The trabecular meshwork (TM), the tissue that primarily regulates intraocular pressure, is known to have reduced cellularity in glaucoma.
Eric Snider, Kelsey P. Kubelick, K. Tweed, R. K. Kim, Yin Li, K. Gao, A. Read, S. Emelianov, C. Ethier   +8 more
semanticscholar   +1 more source

Effects of Bone Morphogenetic Protein‐7 on Steroid‐Induced Extracellular Matrix Accumulation in Human Trabecular Meshwork Cells [PDF]

FASEB Bioadv
Long‐term steroid use can elevate intraocular pressure (IOP) and lead to steroid‐induced glaucoma by promoting extracellular matrix (ECM) accumulation in the trabecular meshwork (TM). This study demonstrates that bone morphogenetic protein‐7 (BMP‐7), delivered via a micellized protein transduction domain (mPTD), effectively inhibits steroid‐induced ECM
Kim E, Choi J, Chae M, Lee J, Lee C, Um J, Kim N, Kim J, Choi W, Kim C.   +9 more
europepmc   +2 more sources

Iris Morphological Features in Patients with 360° Angle-Closure Neovascular Glaucoma: An Anterior Segment Optical Coherence Tomography Study

Case Reports in Ophthalmology, 2018
Purpose: To investigate iris morphological features in 360° angle-closure neovascular glaucoma (NVG) by swept-source anterior segment optical coherence tomography (ASOCT).
Yui Kobayashi, Shunsuke Nakakura, Etsuko Terao, Yuki Fujio, Kanae Matsuya, Hitoshi Tabuchi, Yasuhiro Takahashi, Yoshiaki Kiuchi   +7 more
doaj   +1 more source

A Novel Cranial Bone Transport Technique Repairs Skull Defect and Minimizes Brain Injury Outcome in Traumatic Brain Injury Rats

Advanced Science, EarlyView.
This study introduces a novel, safe, and effective surgical technique: Cranial bone transport (CBT) to improve traumatic brain injury (TBI) outcomes in rats. CBT significantly accelerated skull defect bone repair in addition to its promoting effects on neurological function recovery. This work provides an alternative therapy for patients suffering from
Shanshan Bai, Xuan Lu, Xu Yan, Han Su, Yuejun Lin, Zhaowei Jiang, Zhixian Zong, Haixing Wang, Leo Yik Chun Yan, Xiaoting Zhang, Ming Wang, Zhengmeng Yang, Jiakang Jin, Yaofeng Wang, Wayne Yuk‐Wai Lee, Xiaohua Jiang, Ho Ko, Lu Feng, Micky D. Tortorella, Sien Lin, Gang Li   +20 more
wiley   +1 more source

Human stem cells home to and repair laser-damaged trabecular meshwork in a mouse model

Communications Biology, 2018
Glaucoma is the leading cause of irreversible vision loss, and reducing elevated intraocular pressure is currently the only effective clinical treatment.
Hongmin Yun, Yiwen Wang, Yiwen Wang, Yi Zhou, Yi Zhou, Ke Wang, Ming Sun, D. Stolz, X. Xia, C. Ethier, Yiqin Du   +10 more
semanticscholar   +1 more source

Functionalized Biomimetic Nanoparticles Targeting the IL‐10/IL‐10Rα/Glycolytic Axis in Synovial Macrophages Alleviate Cartilage Degeneration in Osteoarthritis

Advanced Science, EarlyView.
The MOF material UIO‐66‐NH2 is functionalized with DBCO groups on its surface, encapsulating NO‐prednisolone and conjugating it with azide‐modified IL‐10. Finally, the complex is extruded with MM to form biomimetic functional nanoparticles. Upon intra‐articular injection, MI@UN, enveloped by the MM, specifically targets synovial macrophages, is ...
Wenwei Li, Yang Liu, Ming Wei, Zhichao Yang, Zhaoyu Li, Zezhong Guo, Liang Yan, Yang Lu, Hao Tang, Bofeng Li, Wei Huang   +10 more
wiley   +1 more source

Optical Coherence Tomography Observation of Gonio Structures during Microhook Ab Interno Trabeculotomy

Journal of Ophthalmology, 2017
Introduction. Intraoperative observation of ocular structures using microscope-integrated optical coherence tomography (iOCT) has been adopted recently.
Masaki Tanito
doaj   +1 more source