Results 71 to 80 of about 530,939 (289)
COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells
Molecular Oncology, EarlyView.This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos +6 more
wiley +1 more source
Molecular Oncology, EarlyView.Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen +11 more
wiley +1 more source
HCN versus HCO+ as dense molecular gas mass tracer in Luminous Infrared Galaxies [PDF]
, 2006 It has been recently argued that the HCN J=1--0 line emission may not be an unbiased tracer of dense molecular gas ($\rm n\ga 10^4 cm^{-3}$) in Luminous Infrared Galaxies (LIRGs: $\rm L_{FIR}> 10^{11} L_{\odot}$) and HCO$^+$ J=1--0 may constitute a ...
Braine J. +5 more
core +3 more sources
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
Turbulent Mixing in the Interstellar Medium -- an application for Lagrangian Tracer Particles
, 2008 We use 3-dimensional numerical simulations of self-gravitating compressible turbulent gas in combination with Lagrangian tracer particles to investigate the mixing process of molecular hydrogen (H2) in interstellar clouds.
Boldyrev S +17 more
core +1 more source
Heat as a proxy to image dynamic processes with 4D electrical resistivity tomography [PDF]
, 2019 Since salt cannot always be used as a geophysical tracer (because it may pollute the aquifer with the mass that is necessary to induce a geophysical contrast), and since in many contaminated aquifer salts (e.g., chloride) already constitute the main ...
Bolly, Pierre-Yves +4 more
core +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Social image concerns promote cooperation more than altruistic punishment
Nature Communications, 2016 Cooperation requires individuals to sacrifice individual rewards for group benefits. Here, Grimalda, Pondorfer and Tracer show in a foraging society of Papua New Guinea that social image building is a more powerful motivator of social cooperation than ...
Gianluca Grimalda +2 more
doaj +1 more source
Modelling seasonal changes of longitudinal dispersion at the Okna River
Acta Scientiarum Polonorum. Formatio Circumiectus, 2020 Aim of the study: This study presents an opportunity to determine a value of longitudinal dispersion and is focused on the comparison of seasonal variation of the longitudinal dispersion predetermined by natural conditions of the river aquatic zone ...
Martin Manina +3 more
doaj +1 more source
, 2009 In this fluid dynamics video, we demonstrate the microscale mixing enhancement of passive tracer particles in suspensions of swimming microalgae, Chlamydomonas reinhardtii.
Goldstein, Raymond E. +4 more
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