Results 41 to 50 of about 314,401 (249)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

ON THE ISSUE OF STRUCTURAL-SEMANTIC SIMILARITIES OF THE FRENCH AND SERBIAN LANGUAGES AT THE MORPHOLOGICAL LEVEL

Многоязычие в образовательном пространстве, 2020
The article examines similarities between French and Serbian languages at the morphological level. The study of linguistic contacts in modern linguistics is a separate direction, which contributes to the growth of interest in the processes of borrowing ...
D. I. Medvedeva, M. S. Degtyannikova
doaj   +1 more source

Synergy of single-cell sequencing analyses and in vivo lineage-tracing approaches: A new opportunity for stem cell biology [PDF]

, 2022
Yuki Matsushita, Wanida Ono, Noriaki Ono
openalex   +1 more source

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

Molecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson, Anders Lade Nielsen, Boe Sandahl Sorensen   +2 more
wiley   +1 more source

Organization of Valence-Encoding and Projection-Defined Neurons in the Basolateral Amygdala

Cell Reports, 2018
The basolateral amygdala (BLA) mediates associative learning for both fear and reward. Accumulating evidence supports the notion that different BLA projections distinctly alter motivated behavior, including projections to the nucleus accumbens (NAc ...
Anna Beyeler, Chia-Jung Chang, Margaux Silvestre, Clémentine Lévêque, Praneeth Namburi, Craig P. Wildes, Kay M. Tye   +6 more
doaj   +1 more source

Strength through diversity: how cancers thrive when clones cooperate

Molecular Oncology, EarlyView.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken, Maartje Witsen, Emile E. Voest, Krijn K. Dijkstra   +3 more
wiley   +1 more source

Visual tracing of diffusion and biodistribution for amphiphilic cationic nanoparticles using photoacoustic imaging after ex vivo intravitreal injections

International Journal of Nanomedicine, 2016
Xu Xu,* Zhaokang Xu,* Junyi Liu, Zhaoliang Zhang, Hao Chen, Xingyi Li, Shuai Shi Institute of Biomedical Engineering, School of Ophthalmology & Optometry and Eye Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, People’s Republic of ...
Xu X, Xu ZK, Liu JY, Zhang ZL, Chen H, Li XY, Shi S   +6 more
doaj  

Manual tracing and artificial intelligence tracing of lateral cephalograms: A critical comparative assessment of performance

Annales Academiae Medicae Silesiensis
Introduction: Cephalometric analysis, a cornerstone of orthodontics and craniofacial surgery, traditionally involves manual radiograph tracing, a time-consuming and potentially variable process. Artificial intelligence (AI) offers a potential alternative
Qazi Jawad Hayat, Barq Rehman Khan, Ziad Khan, Muhammad Kashif, Muhammad Abdullah Zuhair   +4 more
doaj   +1 more source

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

Molecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto, Louise Raunkilde, Jan Lindebjerg, Mads Malik Aagaard, Christina Therkildsen, Jakob Kleif, Lars Henrik Jensen, Torben Frøstrup Hansen, Rikke Fredslund Andersen   +8 more
wiley   +1 more source

Strategi Penelusuran dan Pelestarian Naskah Kuno oleh Perpustakaan dan Arsip Deli Serdang

Jurnal Humanitas: Katalisator Perubahan dan Inovator Pendidikan
This study aims to explore the search and preservation strategies of ancient manuscripts implemented by the Deli Serdang Library and Archives. The method used is descriptive qualitative, which allows for in-depth analysis of the preservation process ...
Reni Anjani Sumarno, Retno Sayekti
doaj   +1 more source