Results 61 to 70 of about 1,124,915 (299)
The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes
FEBS Letters, EarlyView.Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga +3 more
wiley +1 more source
Quest. Issues in Contemporary Jewish History, 2018 In 2018, the International Tracing Service (ITS) extends the online accessibility of further parts of its 30 million documents on the fate of Holocaust victims, of forced laborers and Displaced Persons.
Christiane Weber
doaj
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
Molecular Oncology, EarlyView.Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang +3 more
wiley +1 more source
Take Note: the Effectiveness of Novice Programmers' Annotations on Examinations
Informatics in Education, 2005 This paper examines results from a multiple-choice test given to novice programmers at twelve institutions, with specific focus on annotations made by students on their tests.
Robert MCCARTNEY +3 more
doaj +1 more source
Tracing transient charges in expanding clusters [PDF]
, 2017 We study transient charges formed in methane clusters following ionization by intense near-infrared laser pulses. Cluster ionization by 400-fs (I=1×1014 W/cm2) pulses is highly efficient, resulting in the observation of a dominant C3+ ion contribution ...
Rouzée, Arnaud +2 more
core +2 more sources
The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity
Molecular Oncology, EarlyView.Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli +7 more
wiley +1 more source
Многоязычие в образовательном пространстве, 2020 The article examines similarities between French and Serbian languages at the morphological level. The study of linguistic contacts in modern linguistics is a separate direction, which contributes to the growth of interest in the processes of borrowing ...
D. I. Medvedeva, M. S. Degtyannikova
doaj +1 more source
Dynamic Key-Value Memory Networks for Knowledge Tracing
, 2017 Knowledge Tracing (KT) is a task of tracing evolving knowledge state of students with respect to one or more concepts as they engage in a sequence of learning activities.
Chen T. +18 more
core +2 more sources
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source