Results 81 to 90 of about 1,309,938 (248)

Understanding Sports Injuries Among Running Athletes In Gorontalo; Treatment Strategies And Prevention Efforts

Jurnal Stamina
This research aims to explore the understanding of running athletes in Gorontalo regarding sports injuries, including how they treat and prevent these injuries.
Arief Ibnu Haryanto, Edy Dharma Putra Duhe, Mohamad Akil Hunta, Wahyu Ramadhan Putra Umadji, Exal Garcia-Carrillo, Moamen Mohamed Abdelgawad Abdelnaser   +5 more
doaj   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

The TREC2001 video track: information retrieval on digital video information [PDF]

, 2002
The development of techniques to support content-based access to archives of digital video information has recently started to receive much attention from the research community.
Over, Paul, Doermann, David, Costello, Cash J., Cash J. Costello, Doermann, D., Smith, John, David Doermann, Paul Over, Vries, Arjen, Alexander Hauptmann, Smeaton, A.F., Hauptmann, A. (Andreas), Vries, A.P. (Arjen) de, Over, P., Hauptmann, Andreas, Costello, Craig, Arjen P. de Vries, Rorvig, Mark E., de Vries, Arjen P., Mark E. Rorvig, Smith, John R., Wu, Lide, Smith, J.R. (John), Alan F. Smeaton, Wu, L., Rorvig, M.E., Lide Wu, Smeaton, Alan F., Costello, C.J. (Craig), Hauptmann, Alexander, John R. Smith   +30 more
core   +3 more sources

DCU at the TREC 2008 Blog Track [PDF]

, 2008
In this paper we describe our system, experiments and re- sults from our participation in the Blog Track at TREC 2008. Dublin City University participated in the adhoc re- trieval, opinion finding and polarised opinion finding tasks.
Foster, Jennifer, Bermingham, Adam, Smeaton, Alan F., Hogan, Deirdre   +3 more
core   +2 more sources

Decision tree analysis of mental resilience trajectory and core influencing factors in patients with traumatic fracture

Zhongguo linchuang yanjiu
Objective To investigate the trajectory of mental resilience in patients with traumatic fracture and analyze the predictive factors of different trajectory subtypes, so as to provide a reference for intervention.
YANG Xiaohui, LIU Wen, ZHANG Xinyan
doaj   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Influence of the railway track parameters to the dynamic responses of the track components

, 2002
It is well known that defective wheels and/or irregularities of the rails generate impact forces. Generally vertical impact forces are determined using either field measurement or 2D simulation models.
Manicka Dhanasekar (9792023), Yan Sun (9838427), Dhanasekar, Manicka., Sun, Yan Quan.   +3 more
core