Results 31 to 40 of about 94,810 (281)

Development and Operation of Track Condition Monitoring System Using In-Service Train

Applied Sciences, 2023
Railway tracks must be managed appropriately because their conditions significantly affect railway safety. Safety is ensured through inspections by track maintenance staff and maintenance based on measurements using dedicated track geometry cars. However,
Hitoshi Tsunashima, Hironori Ono, Tetsuya Takata, Seigo Ogata   +3 more
doaj   +1 more source

State-of-the-Art Review of Railway Track Resilience Monitoring

Infrastructures, 2018
In recent years, railway systems have played a significant role in transportation systems due to the demand increase in conveying both cargo and passengers.
Chayut Ngamkhanong, Sakdirat Kaewunruen, Bruno J. Afonso Costa   +2 more
doaj   +1 more source

Rail Degradation Prediction Models for Tram System: Melbourne Case Study

Journal of Advanced Transportation, 2018
Tram is classified as a light rail mode of transportation. Tram tracks experience high acceleration and deceleration forces of locomotives and wagons within their service life and also share their route with other vehicles.
Amir Falamarzi, Sara Moridpour, Majidreza Nazem, Reyhaneh Hesami   +3 more
doaj   +1 more source

Geometry and stiffness optimization for switches and crossings, and simulation of material degradation

, 2010
A methodology for simulating wear, rolling contact fatigue, and plastic deformation for a mixed traffic situation in switches and crossings (S&C) has been developed.
Kassa, Elias,, Ekh, Magnus,, Nicklisch, Dirk,, Iwnicki, Simon,, M Ekh, Ekh, Magnus, Ekh, M., Nicklisch, D., J Nielsen, Nielsen, J., E Kassa, S Iwnicki, Iwnicki, S.,, Gebretsadik, Elias Kassa,, Nielsen, Jens,, Nielsen, Jens C. O., Nielsen, Jens, Kassa, Elias, D Nicklisch, Kassa, E., Nicklisch, D.,, Iwnicki, S.   +21 more
core   +1 more source

A Discrete Element Model for Degradation of Ballast Tracks [PDF]

PAMM, 2012
AbstractA Discrete Element Model that is capable to describe degradation of ballast tracks in consideration of breakage of the ballast stones is presented. Strong rock is modelled as a granular solid by introduction of breakable bonds with suitable failure criteria between adjacent particles.
Christian Ergenzinger, Robert Seifried, Peter Eberhard   +2 more
openaire   +1 more source

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

FEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace, Alyssa Borges, Charles Arnaud, Tove Karlsson, Nina K. Bröker, Stefanie Barbirz, Marta Bally   +6 more
wiley   +1 more source

Data-Driven Bias Correction and Defect Diagnosis Model for In-Service Vehicle Acceleration Measurements

Sensors, 2020
Track quality instruments use low-cost accelerometers placed on or attached to the floors of operating trains, and these instruments collect substantial amounts of data over short inspection periods.
Lei Bai, Rengkui Liu, Qing Li
doaj   +1 more source

PARK(ing) time–How park deficiency affects the biological clock in a Drosophila model of Parkinson's disease

FEBS Letters, EarlyView.
Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara, Kinga Skoczek, Elzbieta Pyza, Milena Damulewicz   +3 more
wiley   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source