Results 41 to 50 of about 94,810 (281)

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Non-linear influences of track dynamic irregularities on vertical levelling loss of heavy-haul railway track geometry under cyclic loadings

Nonlinear Engineering
With an emphasis on the combined degradation of railway track geometry and components, a new numerical-analytical method is proposed for predicting the track geometrical vertical levelling loss (VLL).
de Melo Andre Luis Oliveira, Kaewunruen Sakdirat, Li Ting, Goto Keiichi   +3 more
doaj   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Bayesian multivariate track geometry degradation modeling and its use in condition-based inspection

Railway Engineering Science
Effective maintenance of railway infrastructure is crucial for safe and comfortable transportation. Among the various degradation modes, track geometry deformation due to repeated loading significantly impacts operational safety.
Huy Truong-Ba, Sinda Rebello, Michael E. Cholette, Venkat Reddy, Pietro Borghesani   +4 more
doaj   +1 more source

Assessing the Impact of Sand-Induced Ballast Fouling on Track Stiffness and Settlement

Geotechnics
This study investigates the impact of sand-induced ballast fouling on railway track performance, focusing on track stiffness (modulus), settlement, and overall degradation.
Mohammed A. Alzhrani, Joseph W. Palese, Allan M. Zarembski    +2 more
doaj   +1 more source

TRACK DEGRADATION ASSESSMENT USING GAGE RESTRAINT MEASUREMENTS

, 2001
Gage restraint is an important indicator of track condition and safety. In 1999, approximately 13% of derailments were caused by reductions in gage restraint and the resulting widening of the track gage.
Carr, Gary A, Fateh, Mahmood, Alfelor, Roemer M   +2 more
core   +1 more source

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

Molecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski, Júlia Perera‐Bel, Alejo Rodriguez‐Vida, Nuria Juanpere, Jihyun Lee, Daniel E. Michaud, Jennifer L. Guerriero, Kent W. Mouw, Aristotelis Bamias, Filipe L. F. Carvalho, Joaquim Bellmunt   +10 more
wiley   +1 more source

Adaptive Degradation Prognostic Reasoning by Particle Filter with a Neural Network Degradation Model for Turbofan Jet Engine

Data, 2018
In the aerospace industry, every minute of downtime because of equipment failure impacts operations significantly. Therefore, efficient maintenance, repair and overhaul processes to aid maximum equipment availability are essential.
Faisal Khan, Omer F. Eker, Atif Khan, Wasim Orfali   +3 more
doaj   +1 more source

Investigating Root Causes of Railway Track Geometry Deterioration – A Data Mining Approach

Frontiers in Built Environment, 2020
Railway track geometry deterioration indicates degradation in the underlying track structures. Monitoring and predicting this behavior are important as is investigating the root causes contributing to the deterioration.
Mikko Sauni, Heikki Luomala, Pauli Kolisoja, Esko Turunen   +3 more
doaj   +1 more source

Performance of staggered bit island spacing adjustment for a SRTR BPMR system

AIP Advances, 2023
One of the key problems facing the designer of data storage devices is how to handle the exponential rise in demand for information storage. To enhance the storage capacity of bit-patterned magnetic recording (BPMR) that stores one data bit in a single ...
M. Mattayakan, S. Koonkarnkhai, P. Kovintavewat, C. Warisarn   +3 more
doaj   +1 more source