Results 111 to 120 of about 21,775 (214)

Genetic architecture of the limbic white matter microstructure in aging and Alzheimer's Disease

Alzheimer's &Dementia, Volume 22, Issue 7, July 2026.
Abstract INTRODUCTION Limbic white matter (WM) abnormalities are prevalent in aging and Alzheimer's disease (AD), but genetic drivers are unclear. METHODS In 2614 older adults (mean age ± SD: 73.7 ± 9.8 years; 26% cognitively impaired) from seven harmonized cohorts enriched for cognitive impairment, we quantified free‐water–corrected diffusion MRI ...
Anna S Lorenz, Aditi Sathe, Yisu Yang, Alaina Durant, Yiyang Wu, Michael E. Kim, Chenyu Gao, Nancy R. Newlin, Karthik Ramadass, Praitayini Kanakaraj, Nazirah Mohd Khairi, Zhiyuan Li, Tianyuan Yao, Yuankai Huo, Logan Dumitrescu, Niranjana Shashikumar, Kimberly R. Pechman, Shannon L. Risacher, Lori L. Beason‐Held, Yang An, Konstantinos Arfanakis, Guray Erus, Christos Davatzikos, Mohamad Habes, Di Wang, Duygu Tosun, Arthur W. Toga, Paul M. Thompson, Elizabeth C. Mormino, Panpan Zhang, Kurt Schilling, Marilyn Albert, Walter Kukull, Sarah A. Biber, Bennett A. Landman, Sterling C. Johnson, Barbara Bendlin, Julie Schneider, David A. Bennett, Angela L. Jefferson, Susan M. Resnick, Andrew J. Saykin, Jennifer E. Below, Timothy J. Hohman, Derek B. Archer, Alzheimer's Disease Neuroimaging Initiative (ADNI), The BIOCARD Study Team (BIOCARD), The Alzheimer's Disease Sequencing Project (ADSP)   +47 more
wiley   +1 more source

Genetically linked brain imaging markers of memory decline in aging and Alzheimer's disease

Alzheimer's &Dementia, Volume 22, Issue 7, July 2026.
Abstract INTRODUCTION Memory is a strong endophenotype for Alzheimer's disease (AD) but is typically detectable only after substantial brain change. Genetically linking late‐life memory with mid‐life brain traits may identify early markers of AD‐related cognitive decline.
Yisu Yang, Anna Lorenz, Aditi Sathe, Kurt G. Schilling, Leslie S. Gaynor, Seo‐Eun Choi, Michael L. Lee, Phoebe Scollard, Emily H. Trittschuh, Shubhabrata Mukherjee, Jesse Mez, Logan C. Dumitrescu, Bennett A. Landman, Paul K. Crane, Michael L. Cuccaro, Timothy J. Hohman, Derek B. Archer   +16 more
wiley   +1 more source

AI‐Driven Mapping of Seizure Spread Patterns

Annals of Neurology, Volume 100, Issue 1, Page 59-73, July 2026.
Objective The focus of epilepsy research has largely been on seizure onset; however, physicians typically examine the patterns of seizure spread past seizure onset as well. This study aims to align automated seizure analysis with clinical practice, leverage deep learning to standardize seizure annotations that varies among physicians, and understand ...
Andrew Y. Revell, Marc Jaskir, Akash R. Pattnaik, William K. S. Ojemann, Erin Conrad, Nishant Sinha, Brittany H. Scheid, Alfredo Lucas, John M. Bernabei, John Beckerle, Joel M. Stein, Sandhitsu R. Das, Brian Litt, Kathryn A. Davis   +13 more
wiley   +1 more source

Cingulate Gradient Dysfunction in End‐Stage Renal Disease: Associations With Clinical Phenotypes and Exploratory Transcriptomic Signatures

CNS Neuroscience &Therapeutics, Volume 32, Issue 7, July 2026.
End‐stage renal disease (ESRD) patients exhibited significant cingulate gradient dysfunction, which was significantly correlated with multiple functional domains, serum urea, and hemoglobin levels. Spatially, these alterations were correlated with genes enriched in neurodegenerative pathways.
Peng Li, Jun‐Ya Mu, Xin‐Yi Zhu, Hui‐Jie Yuan, Zhao‐Yao Luo, Qian‐Ge Zhu, Xuan Niu, Xiu‐Long Feng, Yu Han, Ting Ge, Chen‐Xi Wang, Wen Wang, Ming Zhang   +12 more
wiley   +1 more source

Mapping the Disrupted Connectome in Spinocerebellar Ataxia Type 3: A Network‐Based Statistics Study Identifying Novel Therapeutic Targets for Neuromodulation

CNS Neuroscience &Therapeutics, Volume 32, Issue 7, July 2026.
This study identifies a dual pattern of structural and functional connectome disruption in SCA3 that correlates with clinical severity. Importantly, these abnormal structural connectivities are modulated by TMS, establishing them as promising imaging biomarkers and therapeutic targets for precision neuromodulation intervention.
Lan Ou, Chaoyang Zhou, Xingang Wang, Linfeng Shi, Peiling Ou, Chaodong Xiang, Hui Chen, Xi Chen, Bijia Wang, Wei Chen, Jian Wang, Zhiliang Long, Chen Liu   +12 more
wiley   +1 more source

Structural and Functional Neuroimaging Findings in Fibromyalgia: A Systematic Review

European Journal of Pain, Volume 30, Issue 6, July 2026.
ABSTRACT Background and Objective Fibromyalgia (FM) is a nociplastic chronic pain syndrome in which neuroimaging indicates central nervous system involvement, yet findings remain inconsistent across methods. We systematically reviewed structural and functional neuroimaging studies in adults with FM to identify the most reproducible cross‐modal ...
Flávio Antônio Duboc Flutt, João Pedro de Melo Cortez, Lucas Rego Ramos, Rayssa Paula Paz Furlanetto, Diogo Goulart Corrêa, Nivaldo Ribeiro Villela   +5 more
wiley   +1 more source

Modeled Long‐Term Effects of Psilocybin on Dynamic Activity and Effective Connectivity of Fronto‐Striatal‐Thalamic Circuits

Human Brain Mapping, Volume 47, Issue 10, July 2026.
We used fMRI data from a trial in psychedelic‐naïve healthy participants to show that psilocybin increases dynamic fronto‐striatal‐thalamic activity 4 weeks after dosing. Computational models revealed that reduced structure–function coupling is consistent with the emergence of increased activity dynamics, as well as increased bottom‐up and reduced top ...
Lorenzo Pasquini, Jakub Vohryzek, Anira Escrichs, Yonatan Sanz Perl, Adrian Ponce‐Alvarez, Sebastian Idesis, Manesh Girn, Leor Roseman, Jennifer M. Mitchell, Adam Gazzaley, Morten Kringelbach, David J. Nutt, Taylor Lyons, Robin L. Carhart‐Harris, Gustavo Deco   +14 more
wiley   +1 more source

Neuroimaging Correlates of Post‐Stroke Pain After Ischemic Stroke: Secondary Analysis of the INSPiRE‐TMS Trial

Human Brain Mapping, Volume 47, Issue 10, July 2026.
In 1022 minor ischemic stroke patients, baseline anxiety was associated with new severe pain at 1 year. In the MRI subgroup (N = 391), lesion network mapping implicated a distributed network including the insula, anterior cingulate cortex, and thalamus; Neurosynth decoding showed the highest similarity to pain and nociception terms.
Alina Stegemann, Ana Sofia Rios, Ahmed Khalil, Ulrike Grittner, Uchralt Temuulen, Ramanan Ganeshan, Tim Bastian Braemswig, Andreas Horn, Thomas Ihl, Heinrich J. Audebert, Anna Kufner, Matthias Endres   +11 more
wiley   +1 more source

Thiol‐Based Neuroprotective Copolymers Acutely Restore Redox Metabolism and Mediate Vasogenic Edema in a Mouse Model of Traumatic Brain Injury

Macromolecular Bioscience, Volume 26, Issue 7, July 2026.
In this study, we assess the efficacy of an antioxidant nanoparticle system, NPC3, for alleviating the secondary injury cascade in TBI with a specific focus on ameliorating molecular and structural deficits in a mouse controlled cortical impact model.
Evan T. Curtis, Brandon Z. McDonald, Aria W. Tarudji, Aaron M. Priester, Anthony J. Convertine, Forrest M. Kievit   +5 more
wiley   +1 more source

A new in silico model to precisely design focused ultrasound brain therapies

Medical Physics, Volume 53, Issue 7, July 2026.
Abstract Background Focused ultrasound (FUS) combined with microbubbles enables transient and noninvasive blood–brain barrier (BBB) opening, facilitating targeted drug delivery. However, accurate treatment planning remains difficult due to inter‐patient anatomical variability and the common assumption in simulations that brain tissues behave like water.
Allegra Conti, Marta Grossi, Patricia Cardoso De Andrade, Andrea Duggento, Nicola Toschi   +4 more
wiley   +1 more source