Results 21 to 30 of about 314,235 (257)

Privacy-Preserving Monotonicity of Differential Privacy Mechanisms

Applied Sciences, 2018
Differential privacy mechanisms can offer a trade-off between privacy and utility by using privacy metrics and utility metrics. The trade-off of differential privacy shows that one thing increases and another decreases in terms of privacy metrics and ...
Hai Liu, Zhenqiang Wu, Yihui Zhou, Changgen Peng, Feng Tian, Laifeng Lu   +5 more
doaj   +1 more source

The demand for beer in Czech Republic: inderstanding longrun on- and off-trade price elasticities

Czech Journal of Food Sciences, 2017
We provided estimates of price, cross-price, and income elasticities for on- and off-trade beer consumption using econometric models on time series data from 1994 to 2014.
Stanislava Grosová, Michal Masár, Olga Kutnohorská, Vladimír Kubeš   +3 more
doaj   +1 more source

Relationship of Ecosystem Services in the Beijing–Tianjin–Hebei Region Based on the Production Possibility Frontier

Land, 2021
The supply and demand of ecosystem services are affected by land use. Only a few studies have conducted in-depth quantitative analyses. This study adopted the Beijing–Tianjin–Hebei region as the research area.
Jinjin Wu, Xueru Jin, Zhe Feng, Tianqian Chen, Chenxu Wang, Dingrao Feng, Jiaqi Lv   +6 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Tuning the speed-accuracy trade-off to maximize reward rate in multisensory decision-making

eLife, 2015
For decisions made under time pressure, effective decision making based on uncertain or ambiguous evidence requires efficient accumulation of evidence over time, as well as appropriately balancing speed and accuracy, known as the speed/accuracy trade-off.
Jan Drugowitsch, Gregory C DeAngelis, Dora E Angelaki, Alexandre Pouget   +3 more
doaj   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Principal trade-off analysis

Information Visualization
How are the advantage relations between a set of agents playing a game organized and how do they reflect the structure of the game? In this paper, we illustrate ‘Principal Trade-off Analysis’ (PTA), a decomposition method that embeds games into a low-dimensional feature space. We argue that the embeddings are more revealing than previously demonstrated
Alexander Strang, David Sewell, Alexander Kim, Kevin Alcedo, David Rosenbluth   +4 more
openaire   +3 more sources

Mutational Pathways and Trade-Offs Between HisA and TrpF Functions: Implications for Evolution via Gene Duplication and Divergence

Frontiers in Microbiology, 2020
When a new activity evolves by changes in a pre-existing enzyme this is likely to reduce the original activity, generating a functional trade-off. The properties of this trade-off will affect the continued evolution of both functions. If the trade-off is
Erik Lundin, Joakim Näsvall, Dan I. Andersson   +2 more
doaj   +1 more source

Inhibition of dipeptidyl peptidase 7 impairs lysophagy in LLOMe‐treated HepG2 cells

FEBS Letters, EarlyView.
DPP7 inhibition delays ubiquitin‐dependent lysophagy by attenuating ubiquitin accumulation and the recruitment of SQSTM1 and LC3 to damaged lysosomes, resulting in delayed clearance of damaged lysosomes and impaired restoration of lysosomal homeostasis. Created using FigureLabs (Certificate ID: FL‐PUB‐20260922‐Z99XNX).
Na Yeon Park, Inho Kwon, Yong Hwan Kim, Ji‐Eun Bae, Joon Bum Kim, Seong Hyun Kim, Sungho Maeng, Doo Sin Jo, Dong‐Hyung Cho   +8 more
wiley   +1 more source