Results 41 to 50 of about 284,129 (257)
A complex network framework for the efficiency and resilience trade-off in global food trade
Environmental Research Letters, 2021 Global food trade is crucial for food security and availability. Trade is typically optimized to promote efficiency, whereas resilience is increasingly being recognized as another important objective.
Deniz Berfin Karakoc, Megan Konar
doaj +1 more source
Translating whole‐genome doubling into precision medicine in cancer
Molecular Oncology, EarlyView.Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley +1 more source
LandFor a long time in the past, China has implemented a large number of “Grain for Green” projects (GFGPs) to improve the ecological environment. However, it is still unclear whether excessive GFGPs will exacerbate the trade-off of ecosystem services (ESs).
Yulong Dai +6 more
doaj +1 more source
Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley +1 more source
Spatial biology in cancer epigenetics
Molecular Oncology, EarlyView.Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley +1 more source
China's Trade‐Off Between Economic Benefits and Sulfur Dioxide Emissions in Changing Global Trade
Earth's Future, 2020 China has been suffering from air quality degradation since its ascension into the World Trade Organization in 2001. The unequal exchange that occurs with international trade—that is, developed countries obtaining larger shares of trade‐related value ...
Feng Wang +9 more
doaj +1 more source
FEBS Open Bio, EarlyView.Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young +7 more
wiley +1 more source
Strong and long-range radiative interaction between resonant transitions
Physical Review Research, 2022 Enhancing the radiative interaction between quantum electronic transitions is of general interest. There are two important properties of radiative interaction: the range and the strength.
Lei Ying +5 more
doaj +1 more source
The Bulletin of the Royal College of Surgeons of England, 2017 Cancer care cannot be improved at the expense of elective surgery.
openaire +1 more source
Directed evolution of enzymes at the crossroads of tradition and innovation
FEBS Open Bio, EarlyView.An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova +2 more
wiley +1 more source