Results 51 to 60 of about 1,120,480 (285)

Dynamical trade-offs arise from antagonistic coevolution and decrease intraspecific diversity

Nature Communications, 2017
How a trait evolves depends on the shape of its fitness trade-off. Here, Huang et al. demonstrate evolution of trade-off shape in an experimental predator-prey system and develop a mathematical model of trait evolution when the underlying trade-off can ...
Weini Huang, Arne Traulsen, Benjamin Werner, Teppo Hiltunen, Lutz Becks   +4 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Sparsity-accuracy trade-off in MKL [PDF]

, 2009
We empirically investigate the best trade-off between sparse and uniformly-weighted multiple kernel learning (MKL) using the elastic-net regularization on real and simulated datasets.
Suzuki, Taiji, Tomioka, Ryota
core  

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Tuning the speed-accuracy trade-off to maximize reward rate in multisensory decision-making

eLife, 2015
For decisions made under time pressure, effective decision making based on uncertain or ambiguous evidence requires efficient accumulation of evidence over time, as well as appropriately balancing speed and accuracy, known as the speed/accuracy trade-off.
Jan Drugowitsch, Gregory C DeAngelis, Dora E Angelaki, Alexandre Pouget   +3 more
doaj   +1 more source

Mutational Pathways and Trade-Offs Between HisA and TrpF Functions: Implications for Evolution via Gene Duplication and Divergence

Frontiers in Microbiology, 2020
When a new activity evolves by changes in a pre-existing enzyme this is likely to reduce the original activity, generating a functional trade-off. The properties of this trade-off will affect the continued evolution of both functions. If the trade-off is
Erik Lundin, Joakim Näsvall, Dan I. Andersson   +2 more
doaj   +1 more source

Meta‐analysis fails to show any correlation between protein abundance and ubiquitination changes

FEBS Open Bio, EarlyView.
We analyzed over 50 published proteomics datasets to explore the relationship between protein levels and ubiquitination changes across multiple experimental conditions and biological systems. Although ubiquitination is often associated with protein degradation, our analysis shows that changes in ubiquitination do not globally correlate with changes in ...
Nerea Osinalde, Unai Alduntzin, Gorka Prieto, Ugo Mayor   +3 more
wiley   +1 more source

Managing the trade-off implications of global supply [PDF]

, 2006
The cost versus response trade-off is a growing logistics issue due to many markets being increasingly characterized by demand uncertainty and shorter product life cycles.
Adler, Blackstone, Burns, Caputos, Conway, Correa, Da Silveira, Deming, Eisenhardt, Feitzinger, Ferdows, Ferdows, Fisher, Fisher, Fisher, Gattorna, Geary, Goldratt, Goldratt, Goldratt, Goldratt, Hayes, Hill, Hill, Hill, Kaplan, Lowson, Mapes, Mason-Jones, Mason-Jones, Miles, Newman, Ohno, Roger D.H. Warburton, Roy Stratton, Salamatov, Scheinkopf, Schmenner, Schonberger, Shingo, Skinner, Skinner, Slack, Stratton, Van Hoek, Vastag, Yin   +46 more
core   +1 more source

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source

A complex network framework for the efficiency and resilience trade-off in global food trade

Environmental Research Letters, 2021
Global food trade is crucial for food security and availability. Trade is typically optimized to promote efficiency, whereas resilience is increasingly being recognized as another important objective.
Deniz Berfin Karakoc, Megan Konar
doaj   +1 more source