Results 41 to 50 of about 1,149,451 (336)
Time after time – circadian clocks through the lens of oscillator theory
FEBS Letters, EarlyView.Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo +2 more
wiley +1 more source
Aggressive prostate cancer is associated with pericyte dysfunction
Molecular Oncology, EarlyView.Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero +11 more
wiley +1 more source
Tuning the speed-accuracy trade-off to maximize reward rate in multisensory decision-making
eLife, 2015 For decisions made under time pressure, effective decision making based on uncertain or ambiguous evidence requires efficient accumulation of evidence over time, as well as appropriately balancing speed and accuracy, known as the speed/accuracy trade-off.
Jan Drugowitsch +3 more
doaj +1 more source
The Reward-Complexity Trade-off in Schizophrenia
Computational Psychiatry, 2021 Action selection requires a policy that maps states of the world to a distribution over actions. The amount of memory needed to specify the policy (the policy complexity) increases with the state-dependence of the policy. If there is a capacity limit for
Samuel J. Gershman, Lucy Lai
doaj +1 more source
Molecular Oncology, EarlyView.We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck +12 more
wiley +1 more source
Frontiers in Microbiology, 2020 When a new activity evolves by changes in a pre-existing enzyme this is likely to reduce the original activity, generating a functional trade-off. The properties of this trade-off will affect the continued evolution of both functions. If the trade-off is
Erik Lundin +2 more
doaj +1 more source
, 2016 Large-scale simulations play a central role in science and the industry. Several challenges occur when building simulation software, because simulations require complex software developed in a dynamic construction process. That is why simulation software
Graziotin, Daniel +7 more
core +1 more source
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Strong and long-range radiative interaction between resonant transitions
Physical Review Research, 2022 Enhancing the radiative interaction between quantum electronic transitions is of general interest. There are two important properties of radiative interaction: the range and the strength.
Lei Ying +5 more
doaj +1 more source
Ecological Indicators, 2021 Spatiotemporal characteristics of the trade-off among ecosystem services and its mechanism have been extensively studied. However, studies on the difference in spatiotemporal variation of ecosystem services trade-offs in various climate zones under ...
Menglong Qiu +4 more
doaj +1 more source