Results 51 to 60 of about 1,149,451 (336)

Entropic trade-off relations for quantum operations

open access: yes, 2013
Spectral properties of an arbitrary matrix can be characterized by the entropy of its rescaled singular values. Any quantum operation can be described by the associated dynamical matrix or by the corresponding superoperator.
C. Beck   +11 more
core   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon   +13 more
wiley   +1 more source

A complex network framework for the efficiency and resilience trade-off in global food trade

open access: yesEnvironmental Research Letters, 2021
Global food trade is crucial for food security and availability. Trade is typically optimized to promote efficiency, whereas resilience is increasingly being recognized as another important objective.
Deniz Berfin Karakoc, Megan Konar
doaj   +1 more source

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

open access: yesMolecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris   +10 more
wiley   +1 more source

Optimizing Land Use to Mitigate Ecosystem Service Trade-Offs Using Multi-Scenario Simulation in the Luo River Basin

open access: yesLand
For a long time in the past, China has implemented a large number of “Grain for Green” projects (GFGPs) to improve the ecological environment. However, it is still unclear whether excessive GFGPs will exacerbate the trade-off of ecosystem services (ESs).
Yulong Dai   +6 more
doaj   +1 more source

Taboos and conflicts in decision making: Sacred values, decision difficulty, and emotions

open access: yesJudgment and Decision Making, 2008
Previous studies suggest that choices are perceived as difficult as well as negatively emotion-laden when they tap into moral considerations. However, we propose that the involvement of moral issues and values can also facilitate decisions because people
Martin Hanselmann   +3 more
doaj   +1 more source

‘Trade-off’?!

open access: yesThe Bulletin of the Royal College of Surgeons of England, 2017
Cancer care cannot be improved at the expense of elective surgery.
openaire   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

open access: yesMolecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang   +3 more
wiley   +1 more source

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