Results 41 to 50 of about 1,864,390 (308)

NAPRT loss promotes lung tumor initiation and growth through AKT signaling independently of NAD+ biosynthesis

open access: yesMolecular Oncology, EarlyView.
Loss of NAPRT promotes lung tumor initiation and growth through a noncanonical mechanism, independent of its role in NAD+ biosynthesis. Mechanistically, NAPRT depletion activates the mTORC2‐driven AKT/β‐catenin signaling axis to enhance clonogenic and invasive phenotypes. Furthermore, lung‐specific Naprt deletion significantly increases tumor burden in
Myung Joon Oh   +11 more
wiley   +1 more source

Are Free Trade Agreements contagious? [PDF]

open access: yesJournal of International Economics, 2012
Abstract This paper tests the hypothesis that the domino-like spread of regionalism is partly driven by ‘defensive’ FTAs, i.e. FTAs signed to reduce discrimination created by third-nation FTAs. A theory-based measure is used to test contagion against alternative determinants of regionalism.
Richard Baldwin, Dany Jaimovich
openaire   +5 more sources

Can bilateral trade agreements help induce free trade? [PDF]

open access: yes, 1999
There has been growing debate about whether bilateral trade agreements are damaging multilateral efforts to eliminate barriers to international trade.
Raymond Riezman, Riezman, Raymond Glenn
core  

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

open access: yesAging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Towards achieving sustainable fishing through EU trade agreements?

open access: yesEurope and the World, 2019
The European Union (EU) has been supporting its Common Fisheries Policy (CFP) through its trade powers for 40 years. This practice has evolved significantly over the years. This paper explores this evolution with respect to achieving sustainable fishing
doaj   +2 more sources

Integration Projects of Russia and EAEU: Chance for Extension Export?

open access: yesКонтуры глобальных трансформаций: политика, экономика, право, 2020
The article deals with the possibilities of improving the access of Russian goods to foreign markets through regional trade agreements. Participation in such agreements has acquired mass character in the current century, within their framework about two ...
V. P. Obolenskiy
doaj   +1 more source

Geographical and Product Decomposition of the Trade Agreements Effects in the Asia-Pacific Region

open access: yesПространственная экономика, 2023
Trade integration associated with globalization and regionalization processes has contributed to the expansion of trade among countries of Asia-Pacific Region (APR), with the contribution of the globalization process to the integration effect being ...
Dmitriy Aleksandrovich Izotov
doaj   +1 more source

On the Role of Retaliation in Trade Agreements [PDF]

open access: yesJournal of International Economics, 2007
This paper analyzes the role of retaliation in trade agreements. It shows that, in the presence of private information, retaliation can always be used to increase the welfare derived from such agreements by the participating governments. In particular, it is shown that retaliation is a necessary feature of any efficient equilibrium.
Alberto Martin, Wouter Vergote
openaire   +4 more sources

Self‐Regulated Learning Meets AI: Reinterpreting Self‐Regulation, Co‐Regulation, and Socially Shared Regulation in Human–AI Interaction

open access: yesNew Directions for Adult and Continuing Education, EarlyView.
ABSTRACT Advancing artificial intelligence (AI) has transformed learning and work, yet higher education and professional development programs have not systematically equipped learners for AI‐prevalent environments. This lack of preparation creates uncertainty regarding control, responsibility, trust, and accountability.
Moon‐Heum Cho, Jerusalem Merkebu
wiley   +1 more source

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