Aging Is a Key Driver for Adult Acute Myeloid Leukemia
Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley +1 more source
The renewal of intellectual property-based financing schemes represents a groundbreaking solution to help creative economy actors secure loans using their creative assets.
Sri Handayani +2 more
doaj +1 more source
The Judicial Role in Trademark Law [PDF]
This article considers the judicial role in developing trademark law. The issue is important because proposals for trademark reform often rest on expansive, but unexamined, conceptions of judicial authority.
Grynberg, Michael
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Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang +3 more
wiley +1 more source
Registered trademark protection is territorial, granting legal rights only within the jurisdiction where the mark is registered. To overcome this limitation, the WIPO administers the Madrid System, which allows trademark owners to obtain protection in ...
Ni Ketut Supasti Dharmawan +3 more
doaj +1 more source
Why the Customer Isn’t Always Right: Producer-Based Limits on Rights Accretion in Trademark [PDF]
In this article the author responds to James Gibson’s article Risk Aversion and Rights Accretion in Intellectual Property Law, which offers valuable insights into the extra-judicial dynamics that have contributed to the seemingly unending expansion of ...
Tushnet, Rebecca
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Lessons Learned From a Delayed‐Start Trial of Modafinil for Freezing of Gait in Parkinson's Disease
ABSTRACT Objective Freezing of gait (FOG) in people with Parkinson's disease (PwPD) is debilitating and has limited treatments. Modafinil modulates beta/gamma band activity in the pedunculopontine nucleus (PPN), like PPN deep brain stimulation. We therefore tested the hypothesis that Modafinil would improve FOG in PwPD.
Tuhin Virmani +8 more
wiley +1 more source
This study investigates the use of industrial-grade polydimethylsiloxane (PDMS) for mass production of microfluidic chips through Liquid Silicone Rubber Injection Molding (LSR-IM) technologies.
Raphaël Filion +9 more
doaj +1 more source
Trademarks as Fictitious Commodities: An Erosion of the Public Interest? An Assessment of the use of trademarks over urban space at the example of London’s Regent Street and Paris’ Champs-Elysées [PDF]
With reference to Karl Polyani’s notion of fictitious commodities we evaluate whether the protection of two worldwide known streets, namely ‘Regent Street’ in London and the ‘Champs- Elysées’ in Paris may be perceived as an erosion of the public interest
Ghafele, Roya, Vanderslott, Samantha
core +1 more source
Pelaksanaan Prinsip First To File dalam Penyelesaian Sengketa Merek Dagang Asing di Pengadilan (Studi Kasus Tentang Gugatan Pencabutan Hak Merek “Toast Box” oleh Breadtalk Pte.ltd No: 02/merek/2011/pn.niaga/medan) [PDF]
The registration of trademark done by the Directorate General of Intellectual PropertyRights was intended to obtaine legal certainty and legal protection for the right to trademark in accordance with Law No.15/2001. The registration of trademark through
SITEPU, V. I. (VANIA)
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