Results 91 to 100 of about 7,889 (262)
Weakening the nuclear envelope: Lamin B receptor in melanoma metastasis
Molecular Oncology, EarlyView.LBR‐driven nuclear fragility supports melanoma invasion. A: Melanocyte presents low LBR (Lamin B Receptor) levels, maintaining nuclear integrity and lamina‐chromatin tethering. B: During malignant progression, upregulation of LBR clusters at the INM (Inner Nuclear Membrane) during confined migration causes local lamina weakening and cholesterol ...
Francesca Lorenzini +1 more
wiley +1 more source
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
Revista Chilena de Derecho, 2006 Este artículo trata de los problemas de marcas y competencia desleal que genera el uso de metatags en las páginas Web en la jurisprudencia norteamericana y su posible aplicación en el sistema jurídico españolThis article discusses the problems that the ...
Carlos Amunátegui Perelló
doaj
A Study on the Sublicensing System of Intellectual Property Rights
Journal of Intellectual PropertySublicensing in the context of intellectual property rights refers to a license granted by a licensee to a third party under the authority granted to the licensee.
Sucheol Kim
doaj +1 more source
Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source
Understanding the legal landscape of non-conventional trademarks in India
Цифровое правоAmong contemporary intellectual property debates, non-conventional trademarks (such as sounds, smells, tastes, shapes, and holograms) present unique challenges.
S. Sheikh
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Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
From traditional trademark to atypical trademark : example of olfactory trademark
, 2014 European law allows theoretically since 1988 the registration of all kind of trademarks, olfactory ones included. The legal protection of such signs using trademarks law became necessary with the birth of olfactory marketing. However, in the actual state of knowledge, the requirement by the European Court of Justice of a graphic representation as a ...
openaire +1 more source
FEBS Open Bio, EarlyView.CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point +7 more
wiley +1 more source
Aspects of National and Community Trademarks
EIRP Proceedings, 2012 When Romania joined the EU on January 1, 2007, all Community trademarks (CTM), with thefiling date before that date, were automatically extended and have effects in Romania. National brands do notextend across the EU. In order to obtain a Community trade
Constantin Anechitoae, Calin Marinescu
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