Results 101 to 110 of about 574,481 (313)

Rapid screening of staphylokinase protein variants using an unpurified cell‐free expression system

open access: yesFEBS Open Bio, EarlyView.
An unpurified cell‐free protein synthesis (CFPS) platform enables rapid functional screening of staphylokinase variants. Direct plasminogen‐activation assays performed in microplate format provide real‐time activity readouts, allowing rapid identification and ranking of variants with improved or reduced fibrinolytic activity without protein ...
Maria Tomková   +3 more
wiley   +1 more source

Anti-obesity effects of Wumeishanzhayin: an integrated lipidomics and transcriptomics study

open access: yesFrontiers in Pharmacology
BackgroundThe global prevalence of adult obesity has increased significantly, affecting over 890 million adults worldwide. Wumeishanzhayin (WMSZY), a formulation derived from four medicinal and edible botanical drugs, has shown efficacy in alleviating ...
Xiao Huang   +7 more
doaj   +1 more source

Culture and Tradition; Culture et tradition

open access: yes, 1978
Contributors/Collabeurators -- "The bayman food market is in the townie dump” : identity and the townie Newfoundlander / Martin -- Viisseau Fantome et bateau de feu / Marie Claude Roy, Mireille Trudelle --The singing of old Newfoundland ballads and a ...

core  

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

open access: yesFEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane   +11 more
wiley   +1 more source

Culture and Tradition; Culture et tradition

open access: yes, 1983
Production d'une tradition ou production de traditions? / Yves Bergeron -- Death and dying in Newfoundland / Christine Cartwright -- The good wake: a Newfoundland case study / Anne-Kay Buckley with Christine Cartwright -- Games and storytelling at the ...

core  

Why human connection is the true metric of research success

open access: yesFEBS Open Bio, EarlyView.
Human‐centred mentorship can be shaped by mentor attributes, actions, intrinsic drive and career ambition. Drawing on reflections across Singapore and France, as well as workshop insights from FEBS‐IUBMB ENABLE 2024, this article shows that human‐centred mentorship creates the conditions for sustainable growth, well‐being and retention in research ...
Timothy Lin Yun Tan   +3 more
wiley   +1 more source

The Viability of the Rhetorical Tradition

open access: yes
Interrogates the story of rhetoric promoted in standard historical accounts and reconsiders the relationship between rhetorical theory, practice, and pedagogy.Intro -- The Viability of the Rhetorical Tradition -- Contents -- Acknowledgments ...
Mailloux, Steven.   +3 more
core  

Culture and Tradition; Culture et tradition

open access: yes, 1998
Schindler's List as Jewish rite: the esoteric-exoteric factor of cinema-going / Mikel J. Koven -- The phenomenon and essence of Strange Fruit / Jonnie Bakan -- An ethnography of the St. John's airport: applying social network theory through observation /

core  

Refinement of amino‐acid conformation vs. difference density maps in time‐resolved serial femtosecond crystallography data analysis

open access: yesFEBS Open Bio, EarlyView.
The dFoCC pipeline starts with observed DED and resting‐state coordinates, which are then used to generate a library of triggered states. Correlation analysis of the calculated DED features of each candidate vs observed DED permits quantitative evaluation of candidate structural quality.
Meng Iao Fong   +3 more
wiley   +1 more source

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