Results 111 to 120 of about 2,512,595 (306)
FEBS Open Bio, EarlyView.This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel +4 more
wiley +1 more source
“Islamic Tradition”: Questioning the Bosnian Model
, 2019 Debates over whether there can be a ‘European Islam’ have not ceased since 1990s when the term was coined by Bassam Tibi. This paper aims to question the idea of a ‘progress towards a liberal Islam’ as being too straightforward by providing historical ...
Hesová, Zora
core
MGIMO Review of International Relations, 2017 In the analyzed publication the author presents the various aspects of the development of scientific school at MGIMO-University. The author made a special emphasis on the “human” dimension on the disclosure of personal features of the heroes of memories, who were somehow connected with the Moscow State Institute of International Relations.
openaire +3 more sources
Digital twins to accelerate target identification and drug development for immune‐mediated disorders
FEBS Open Bio, EarlyView.Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley +1 more source
Rapid screening of staphylokinase protein variants using an unpurified cell‐free expression system
FEBS Open Bio, EarlyView.An unpurified cell‐free protein synthesis (CFPS) platform enables rapid functional screening of staphylokinase variants. Direct plasminogen‐activation assays performed in microplate format provide real‐time activity readouts, allowing rapid identification and ranking of variants with improved or reduced fibrinolytic activity without protein ...
Maria Tomková +3 more
wiley +1 more source
The Just War Tradition and Natural Law [PDF]
, 2004 This Essay is divided into three parts. First, it briefly discusses Augustine on the notion of a naturalistic morality implanted in human minds and hearts. Second, it traces the ways in which such notions as human nature figure in Augustinian and post-
Elshtain, Jean Bethke
core +1 more source
FEBS Open Bio, EarlyView.Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane +11 more
wiley +1 more source
, 2014 Excerpt: ...I propose to explore one expression of this more ancient and eastern tradition, as found in the cosmic vision of Maximus the Confessor. After a brief sketch of his life and times and his relationship to the larger orthodox tradition I will ...
Overman, Steve
core
Why human connection is the true metric of research success
FEBS Open Bio, EarlyView.Human‐centred mentorship can be shaped by mentor attributes, actions, intrinsic drive and career ambition. Drawing on reflections across Singapore and France, as well as workshop insights from FEBS‐IUBMB ENABLE 2024, this article shows that human‐centred mentorship creates the conditions for sustainable growth, well‐being and retention in research ...
Timothy Lin Yun Tan +3 more
wiley +1 more source