Results 31 to 40 of about 146,044 (265)
HeliyonWhile the regulatory roles of circular RNAs (circRNAs) and zinc finger CCCH-type containing 13 (ZC3H13) were previously reported in various human cancers, the mechanisms underlying their interaction in papillary thyroid cancer (PTC) remain unclear.
Kun Lv +4 more
doaj +1 more source
الإيضاح, 2020 "Al-Mu'jam"by Imām Muhammad ibn Ibrahim ,a prominent Muslim Scholar, is a key source of Ḥadiths. His methodology of a strict scrutiny of Asnad for collecting Hadiths is unique and testifies his scholarly disposition. This book has won an iconic place in
Midhat zidan Salem abu Gholiba
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Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding
FEBS Letters, EarlyView.In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança +2 more
wiley +1 more source
BMC Complementary and Alternative Medicine, 2019 Background Tianshu capsule (TSC), a formula of traditional Chinese medicine, has been widely used in clinical practice for prophylactic treatment of headaches in China.
Shengyuan Yu +22 more
doaj +1 more source
Structural and biochemical analysis of a B12 superbinder
FEBS Letters, EarlyView.BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices +3 more
wiley +1 more source
Gut–ovary axis and multiomic insights into PCOS in a DHEA-induced rat model
Scientific ReportsThis study aims to investigate gut microbiota and metabolomes of fecal, cecum, serum, and ovarian tissues in a DHEA-induced rat polycystic ovary syndrome (PCOS) model and explore the gut–ovary axis in PCOS pathogenesis.
Zhi Chen +11 more
doaj +1 more source
Suspensão e neutralidade evidencial
Perspectiva Filosófica, 2020 Neste artigo discuto uma tese sobre a racionalidade da suspensão de juízo de que suspensão de juízo racional requer neutralidade evidencial. Após traçar alguns pontos sobre as noções probabilísticas de neutralidade e suporte evidencial, aponto uma ...
Luis Rosa
doaj +1 more source
FEBS Letters, EarlyView.Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav +2 more
wiley +1 more source
Prospecting the protein design landscape
FEBS Letters, EarlyView.This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona +4 more
wiley +1 more source
FEBS Letters, EarlyView.Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise +5 more
wiley +1 more source