Results 51 to 60 of about 1,643,209 (329)

Suspensão e neutralidade evidencial

Perspectiva Filosófica, 2020
Neste artigo discuto uma tese sobre a racionalidade da suspensão de juízo de que suspensão de juízo racional requer neutralidade evidencial. Após traçar alguns pontos sobre as noções probabilísticas de neutralidade e suporte evidencial, aponto uma ...
Luis Rosa
doaj   +1 more source

Educative tradition and Islamic schools in Indonesia

, 2015
An Islamic school that subscribes to an educative tradition is essentially one that sees compatibility between the inculcation of religious values and the acquisition of ‘modern’ knowledge and dispositions.
Charlene Tan
semanticscholar   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Gut–ovary axis and multiomic insights into PCOS in a DHEA-induced rat model

Scientific Reports
This study aims to investigate gut microbiota and metabolomes of fecal, cecum, serum, and ovarian tissues in a DHEA-induced rat polycystic ovary syndrome (PCOS) model and explore the gut–ovary axis in PCOS pathogenesis.
Zhi Chen, Qiongqiong Lu, Aolei Lin, Meiao Tan, Wei Li, Sisi Tang, Junyu Feng, Cong Hou, Yu Zhu, Mengxue Xu, Tianjiao Liu, Ming Xia   +11 more
doaj   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Praefatio - Preface

Ciceroniana On Line, 2020
For many of us this congress was the last such event before the outbreak of the coronavirus pandemic in February 2020. Our meeting concluded with an optimistic message of hope, but this was not the kind of hope that would make us nimis creduli postero ...
Katarzyna Marciniak
doaj   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

The Scylla and Charybdis of Libertarian Christology

TheoLogica
Any Christology that posits a libertarian sense of free agency to Christ in his humanity is caught in a dilemma between two conciliar heresies. If it affirms the orthodox view that Christ has two wills (dyothelitism), then it succumbs to Nestorianism ...
Randall K. Johnson
doaj   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

The Kraepelinian tradition

Dialogues in Clinical Neuroscience, 2015
Emil Kraepelin (1856-1926) was an influential figure in the history of psychiatry as a clinical science. This paper, after briefly presenting his biography, discusses the conceptual foundations of his concept of mental illness and follows this line of thought through to late 20th-century "Neo-Kraepelinianism," including recent criticism, particularly ...
openaire   +4 more sources