Results 91 to 100 of about 3,154,939 (307)

Overview of molecular signatures of senescence and associated resources: pros and cons

FEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas, Sylvia Vagena, Pavlos Pantelis, Giorgos Theocharous, Russel Petty, Konstantinos Evangelou, Vassilis G. Gorgoulis   +6 more
wiley   +1 more source

SMYD5-BRD4 Interaction Drives Hepatocellular Carcinoma Progression: A Combined in Silico and Experimental Analysis

Pharmaceuticals
Background/Objectives: Hepatocellular carcinoma (LIHC) poses significant challenges due to limited targeted therapeutic options. This study investigates SMYD5, an oncogene implicated in the pathogenesis of LIHC, and its interaction with the BRD4 protein.
Mingye Hu, Shiji Chen, Yumiao Zhen, Xin Wang, Yiwen Zhong, Xiaoxu Liang, Cheong-Meng Chong, Hai-Jing Zhong   +7 more
doaj   +1 more source

Escape Room vs. Traditional Assessment in Physiotherapy Students' Anxiety, Stress and Gaming Experience: A Comparative Study. [PDF]

Int J Environ Res Public Health, 2021
Molina-Torres G, Sandoval-Hernández I, Ropero-Padilla C, Rodriguez-Arrastia M, Martínez-Cal J, Gonzalez-Sanchez M.   +5 more
europepmc   +1 more source

Exploring rater judging behaviour using the many-facet rasch model [PDF]

, 2007
Performance assessment, unlike the traditional fixed-response assessment, has features peculiar to its assessment setting (the task choice, the task processing conditions, the raters,the rating scale, and the rating procedures) that make it much more ...
Abu Kassim, Noor Lide
core  

Assessment Methods: Traditional Exams vs. Continuous Assessment

Universal Research Reports
Assessment methods play a crucial role in the educational process, providing a means to evaluate student learning, progress, and performance. This research paper explores the differences between traditional exams and continuous assessment, highlighting their respective advantages and disadvantages.
openaire   +1 more source

ATG4B is required for mTORC1‐mediated anabolic activity and is associated with clinical outcomes in non‐small cell lung cancer

FEBS Open Bio, EarlyView.
The relationship between anabolic and catabolic processes governing lung cancer cell growth is nuanced. We show that ATG4B, an autophagy regulator, is elevated in lung cancer and that high ATG4B is associated with worse patient outcomes. Targeting ATG4B in cells reduces growth, protein synthesis, and mTORC1 activity, demonstrating a new relationship ...
Patrick J. Ryan, Bethany C. Guerra, Selina Uranga, Jessica M. Cardin, Steven E. Riechman, Mariana Janini Gomes, James D. Fluckey   +6 more
wiley   +1 more source

Integrating high-resolution bioassay profiling with affinity-based ligand fishing for unveiling galloylated derivatives as novel catechol-O-methyltransferase inhibitors in Paeonia lactiflora Pall.

Journal of Pharmaceutical Analysis
Catechol-O-methyltransferase (COMT) inhibition is a critical therapeutic strategy for Parkinson's disease (PD), yet clinical inhibitors face limitations in bioavailability and hepatotoxicity, driving demand for novel natural scaffolds.
Jiaming Yuan, Zhuoping Zheng, Zhongkang Wang, Hao Tian, Lingling Xi, Jacques Crommen, Tingting Zhang, Jincai Wang, Zhengjin Jiang   +8 more
doaj   +1 more source

A dialogical approach to developing professional competence in assessment [PDF]

, 2012
Improving the students learning experience is closely connected with the promotion an implementation of an assessment strategy whose effectiveness relies on the quality of the formative aspect.
Lorenzi, Francesca, Rami, Justin
core   +1 more source

Evolutionary dynamics of the chloroplast genome in Daphne (Thymelaeaceae): comparative analysis with related genera and insights into phylogenetics

FEBS Open Bio, EarlyView.
Comparative analysis of chloroplast genomes from 14 genera of Thymelaeaceae revealed variation in gene content, ranging from 128 to 142 genes, primarily influenced by IR expansion/contraction events and pseudogenization of ndhF, ndhI, and ndhG. Two large inversions were detected within the large single‐copy region, including a synapomorphic inversion ...
Abdullah, Hui Li, Rushan Yan, Chengyu Chen, Madiha Islam, Abdul Majid, Ibrar Ahmed, Parviz Heidari, Xiaoxuan Tian   +8 more
wiley   +1 more source

Capturing the Real-Time Hydrolytic Degradation of a Library of Biomedical Polymers by Combining Traditional Assessment and Electrochemical Sensors. [PDF]

Biomacromolecules, 2021
Fuoco T, Cuartero M, Parrilla M, García-Guzmán JJ, Crespo GA, Finne-Wistrand A.   +5 more
europepmc   +1 more source