Results 151 to 160 of about 72,133 (284)

Soft‐Drug‐Inspired MnSTF Nano‐Adjuvant for Safe and Synergistic cGAS–STING Activation in Tumor Immunotherapy

open access: yesAdvanced Science, Volume 13, Issue 9, 13 February 2026.
This study introduces MnSTF, a soft‐drug‐inspired nanoadjuvant that overcomes the systemic toxicity of STING agonists. Through Mn2+ coordination with an ENPP1 inhibitor, it enables safe cGAS‐STING activation, remodels the tumor immune microenvironment, and synergizes with radiotherapy or vaccines to elicit robust antitumor immunity.
Guangfei Sun   +8 more
wiley   +1 more source

Spatial heterogeneity in microglia‐complement crosstalk: Implications for synaptic pruning in Alzheimer's disease

open access: yesAlzheimer's &Dementia, Volume 22, Issue 2, February 2026.
Abstract Alzheimer's disease (AD) is a neurodegenerative disorder characterized by synaptic loss, as a key pathological feature in its early stages. Recent studies have highlighted the central role of microglia–complement interactions in synaptic pruning.
Qiuyan Ye   +10 more
wiley   +1 more source

Traditional Chinese Medicine (TCM) in the treatment of COVID-19 and other viral infections: Efficacies and mechanisms. [PDF]

open access: yesPharmacol Ther, 2021
Huang K   +6 more
europepmc   +1 more source

AI and Big Data in Oncology: A Physician‐Centered Perspective on Emerging Clinical and Research Applications

open access: yesCancer Innovation, Volume 5, Issue 1, February 2026.
Artificial intelligence and big data platforms are transforming oncology clinical practice. This review proposes a physician‐centered framework to integrate AI tools with real‐world data, supporting more precise diagnosis, individualized treatment, and improved patient outcomes.
Binliang Liu   +7 more
wiley   +1 more source

Buyang Huanwu Decoction Alleviates Bleomycin‐Induced Pulmonary Fibrosis via Wnt/β‐catenin and TGF‐β1/Smad Pathways

open access: yesChemistry &Biodiversity, Volume 23, Issue 2, February 2026.
The supernatant fraction of Buyang Huanwu Decoction, obtained by ethanol precipitation, demonstrates superior efficacy against pulmonary fibrosis. It enhances the bioavailability of key compounds and dually inhibits Wnt/β‐catenin and TGF‐β1/Smad pathways, presenting a potent therapeutic strategy.
Yunyue Zhou   +7 more
wiley   +1 more source

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