Results 41 to 50 of about 5,668,692 (245)

Advances in nanotechnology-augmented T cell-based novel cancer immunotherapies

Nano Research
Malignant tumors are a leading global cause of death, motivating advances in treatment strategies. Conventional immunotherapies, including checkpoint inhibitors, vaccines, and cytokine therapies are limited by low response rates, toxicity, or target ...
Xinling He, Jing Du, Lingzhuo Zeng, Fan Tong, Jiaqi Ma, Nan Zeng, Chuan Hu, Huile Gao, Jinming Zhang   +8 more
doaj   +1 more source

Bergenia Genus: Traditional Uses, Phytochemistry and Pharmacology

Molecules, 2020
Bergenia (Saxifragaceae) genus is native to central Asia and encompasses 32 known species. Among these, nine are of pharmacological relevance. In the Indian system of traditional medicine (Ayurveda), “Pashanabheda” (stone breaker) is an elite drug ...
Bhupendra Koul, Arvind Kumar, Dhananjay Yadav, Jun-O. Jin   +3 more
doaj   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Regulation of bile acids homeostasis: a feasible and versatile way to treat or diagnose liver disorders

Frontiers in Nutrition
Homeostatic imbalance of bile acids (BAs) is closely associated with the onset and progression of several liver diseases, including cholestasis, hepatic fibrosis, cirrhosis, hepatocellular carcinoma, and MASLD/MASH.
Qian-Qian Wu, Qian-Qian Wu, Le-Ying Gao, Le-Ying Gao, Hui-Yi Feng, Hui-Yi Feng, Hao-Lin Liu, Hao-Lin Liu, Hui Gao, Wei Peng, Wei Peng, Nan Li, Nan Li   +12 more
doaj   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Novel genetic insights into causal effects of potential metformin targets and immune mediation on sepsis

Biology Direct
Background Sepsis remains a major global clinical challenge with limited therapies. Metformin shows promising therapeutic potential, likely through immune modulation, yet mechanistic evidence remains scarce.
Li Xiang, Jiayi Sun, Lu Yang, Yanqin Luo, Yiwen Wang, Keling Chen, Xianli Meng   +6 more
doaj   +1 more source

Prospecting the protein design landscape

FEBS Letters, EarlyView.
This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona, Katharina T. Stonig, Jens Meiler, Clara T. Schoeder, Monica L. Fernández‐Quintero   +4 more
wiley   +1 more source

Targeting the sirtuin 6–NF-κB p65 axis by 6-hydroxyhyoscyamine hydrobromide: a deacetylation-driven new therapy for diabetic wounds

Cellular & Molecular Biology Letters
Background Diabetic wounds are a debilitating complication of diabetes mellitus with a high rate of amputation and mortality. 6-Hydroxyhyoscyamine hydrobromide (6-HH) is a belladonna alkaloid with smooth-muscle-relaxing and microcirculation-enhancing ...
Junren Chen, Siqi Qin, Ziwei Xing, Feng Wan, Jie Yin, Cheng Peng, Dan Li   +6 more
doaj   +1 more source

Emerging roles of protein modifications in sexual reproduction and pathogenesis of filamentous fungi

Frontiers in Microbiology
Posttranslational modifications play pivotal roles in the regulation of protein function, enabling precise and dynamic control of diverse cellular processes in fungi.
Xiaoxing Li, Xin Zhou, Yuchen Luo, Luman Xue, Xinxin Tong, Jinlin Guo   +5 more
doaj   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source