Results 71 to 80 of about 41,387 (309)

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

open access: yesMolecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li   +10 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

open access: yesMolecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Islam in the contemporary world: Western image and Muslim ideology [PDF]

open access: yes, 2005
The issue of Western perceptions of Islam, and concerns about Islamic ideology vis-à-vis the relation of Muslims to the West, constitute topics of ongoing concern both for Muslims and non-Muslims alike. They have come to the fore in a dramatic sense this
Pratt, Douglas
core   +1 more source

Love at the cultural crossroads: Intimacy and commitment in Chinese Canadian relationships [PDF]

open access: yes, 2010
This is the post-print version of the Article. The official published version can be accessed from the link below - Copyright @ 2010 Wiley-BlackwellThe role of culture in romantic relationships has largely been investigated by examining variation between
Marshall, TC
core   +1 more source

RaMBat: Accurate identification of medulloblastoma subtypes from diverse data sources with severe batch effects

open access: yesMolecular Oncology, EarlyView.
To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley   +1 more source

Mediation and moral culture of society

open access: yesАнтиномии, 2018
The article is devoted to the analysis of moral aspects of development of mediation as socio-legal institution. It is noted that the term “mediation” in various areas of research refers to different phenomena: in socio-legal research – to alternative ...
Elena N. Yarkova
doaj   +1 more source

Reforming the family code in Tunisia and Morocco - the struggle between religion, globalisation and democracy [PDF]

open access: yes, 2010
There is no doubt that one of the most contentious terrains of contestation in the supposed clash of values between Islamism and western values is the role of women in society.
Cavatorta, Francesco, Dalmasso, Emanuela
core   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

open access: yesMolecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley   +5 more
wiley   +1 more source

¿Racionalismo sin vanguardia? Pedro Muguruza en el Paseo de La Concha de San Sebastián = Rationalism without avant-garde? Pedro Muguruza at the Paseo de La Concha in San Sebastian

open access: yesCuaderno de Notas, 2020
Resumen En el Paseo de la Concha de San Sebastián existe una casa proyectada por Pedro Mu­guruza antes de la guerra civil y construida tras el final de la contienda.
Mariano González Presencio   +1 more
doaj   +1 more source

Rationality, traditionalism and the state of corporate governance mechanisms: illustrations from a less developed country [PDF]

open access: yes, 2008
Purpose ? The purpose of this research is to provide an account of corporate governance practices in Bangladesh. This paper demonstrates that the traditionalist culture mediates the rationalist/legalist framework of corporate governance in Bangladesh ...
Choudhury, J, Uddin, S
core  

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