Results 61 to 70 of about 9,117 (281)

M.M. Speransky and N.M. Karamzin: Two Ways of Civilized Development of Russia or a Dispute About a Rational System of Public Administration?

open access: yesВестник Волгоградского государственного университета. Серия 4. История, регионоведение, международные отношения, 2019
Introduction. The introduction identifies one of the most important problems in the political history of Russia – the problem of determining and choosing the path of the long-term civilizational development in the aspect of liberal and conservative ...
Oleg V. Kuznetsov   +2 more
doaj   +1 more source

PATRIARCHY IN THE SCHOOL: COVARIATES OF GENDER TRADITIONALISM IN ADOLESCENCE [PDF]

open access: yes
Gender traditionalism is one of the cultural traits of contemporary Romania which has severe consequences on the effectiveness of human resource allocation.
Hatos Adrian
core  

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

open access: yesFEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante   +10 more
wiley   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

open access: yesFEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass   +2 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

open access: yesMolecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

open access: yesMolecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Mediation and moral culture of society

open access: yesАнтиномии, 2018
The article is devoted to the analysis of moral aspects of development of mediation as socio-legal institution. It is noted that the term “mediation” in various areas of research refers to different phenomena: in socio-legal research – to alternative ...
Elena N. Yarkova
doaj   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

open access: yesMolecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary   +1 more
wiley   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

open access: yesMolecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Carlism and Spanish political tradition: yesterday and today

open access: yesАнтиномии, 2019
The article analyzes the evolution of the key ideological concepts of Carlism – a mass social and political movement that arose in Spain in 1833 as a result of the dynastic crisis after the death of King Fernando VII, and led in the 19th century to ...
Miguel Ayuso Torres
doaj   +1 more source

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