Results 51 to 60 of about 9,117 (281)
Traditionalism involves the concept of a perennial philosophy, a central truth, underlying all major religions. Though little has been written about Swedish Traditionalism, consideration of the ideologies of figures such as Ivan Aguéli, Kurt Almqvist ...
Hammer, Olav; id_orcid
core +1 more source
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi +6 more
wiley +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Liver organoids: modelling complexity in homeostasis and disease
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
Persistence of traditionalist value orientations in Serbia [PDF]
Systematic failures in attempts to modernize Serbian society during the past two centuries have led to the survival of traditionalist value orientations. The long period of Ottoman rule allowed patriarchal, warrior-tribal cultural patterns to persist and
Pešić Jelena
doaj +1 more source
Epigenetic reprogramming of lineage switching in cancer
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı +4 more
wiley +1 more source
The immured woman, Odysseus and Bulgarian Easter: Toncho Zhechev and the quest for a conservative myth This article reflects on Bulgarian Easter, or Bulgarian Passions, a 1975 book by the Bulgarian humanist Toncho Zhechev, once regarded in Communist ...
Grażyna Szwat-Gyłybowa
doaj +1 more source
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
Vekkelser i et samfunnsperspektiv [PDF]
Revivals in a political-cultural perspective. The pietistic revivals in Norway, beginning with the lay preacher Hans Nielsen Hauge just before the 19th Century, were structured by the religious policy of the king of Denmark-Norway.
Bernt Torvild Oftestad
doaj

