Results 81 to 90 of about 41,264 (308)

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Islam in the contemporary world: Western image and Muslim ideology [PDF]

, 2005
The issue of Western perceptions of Islam, and concerns about Islamic ideology vis-à-vis the relation of Muslims to the West, constitute topics of ongoing concern both for Muslims and non-Muslims alike. They have come to the fore in a dramatic sense this
Pratt, Douglas
core   +1 more source

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

Molecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson, Anders Lade Nielsen, Boe Sandahl Sorensen   +2 more
wiley   +1 more source

Effect of chemotherapy on passenger mutations in metastatic colorectal cancer

Molecular Oncology, EarlyView.
Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui, Matthew A. Cottam, Muhammad Bilal Mirza, Keeli B. Lewis, Kristen K. Ciombor, Mary Kay Washington, Kamran Idrees   +6 more
wiley   +1 more source

CONTEMPORARY TRENDS IN THE MIDDLE EAST AND CENTRAL ASIA

Vestnik MGIMO-Universiteta, 2019
Book Review: I. Zvyaglskaya Middle East and Central Asia: Global trends in regional execution. Moscow: “Aspect Press”, 2018. 224 p. (In Russian)“Middle East and Central Asia: Global trends in regional execution” is an analysis of the main trends in the ...
N. Y. Surkov
doaj   +1 more source

Normal and Abnormal Personality Traits are Associated with Marital Satisfaction for both Men and Women: An Actor–Partner Interdependence Model Analysis [PDF]

, 2010
Research has demonstrated associations between relationship satisfaction and personality traits. Using the Actor–Partner Interdependence Model, we explored associations between self-reported relationship satisfaction in couples (n = 118) and various ...
Durbin, C. Emily, Knobloch-Fedders, Lynne M., Saigal, Seema D., Stroud, Catherine B.   +3 more
core   +1 more source

Romantic ideals, mate preferences, and anticipation of future difficulties in marital life: a comparative study of young adults in India and America [PDF]

, 2014
This article has been made available through open access by the Brunel Open Access Publishing Fund.Previous studies have established that Indians tend to be greater in collectivism and gender role traditionalism than Americans. The purpose of the present
Andrade, Banerjee, Barnett, Bartley, Batabyal, Beilmann, Bianchi, Buss, Buss, Buunk, Buunk, Chafetz, Chakraborty, Cherlin, Cialdini, Claffey, Das, Das, Derne, Dhar, Eagly, Fisher, Fromm, Gala, Georgas, George, Gilbert, Goodwin, Greenfield, Hagger, Hallett, Harlan, Hatfield, Hatfield, Hofstede, Imada, Imada, Jankowiak, Kashima, Krishnan, Lalonde, Larsen, Larson, Le, Levine, Lykes, MacDonald, MacDonald, MacKinnon, Madathil, Manohar, Markus, Marshall, Marshall, Mathes, Medora, Moore, Morgan, Myers, Nath, Neto, Neto, Netting, Peplau, Perrone-McGovern, Perry-Jenkins, Pitt, Preacher, Regan, Richerson, Sandhya, Sastry, Schmitt, Shukla, Singh, Sivadas, Sonawat, Sonpar, Sprecher, Stanik, Suppal, Triandis, Twamley, Uberoi, Wang, Wierda-Boer, Williams, Wolkomir, Zhang   +88 more
core   +3 more sources

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

Strength through diversity: how cancers thrive when clones cooperate

Molecular Oncology, EarlyView.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken, Maartje Witsen, Emile E. Voest, Krijn K. Dijkstra   +3 more
wiley   +1 more source

Perspectives in educating molecular pathologists on liquid biopsy: Toward integrative, equitable, and decentralized precision oncology

Molecular Oncology, EarlyView.
Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié, Umberto Malapelle, Catherine Alix‐Panabières, Claus Lindbjerg Andersen, Sandra Chlebowski, Vivien Lake, Caroline Lacoux, Virginie Lespinet‐Fabre, Olivier Bordone, Simon Heeke, Christophe Bontoux, Ellen Heitzer, Klaus Pantel, Paul Hofman   +13 more
wiley   +1 more source