Results 61 to 70 of about 2,342 (222)

Plasmepsins as Antimalarial Drug Targets—Then, Now, and the Future

Medicinal Research Reviews, EarlyView.
ABSTRACT Malaria is a devastating disease caused by Plasmodium parasites. Plasmodium parasites express ten cathepsin D‐like aspartyl proteases, called plasmepsins (PMs). These PMs have diverse roles fulfill diverse functions throughout the parasite's lifecycle, though several exhibit functional redundancies. Among them, PMV, PMIV, and PMX are essential
Brad E. Sleebs
wiley   +1 more source

Effects of Perioperative Music Interventions on Emotional Outcomes in Children and Adolescents: A Systematic Review and Meta‐Analysis Integrating Developmental Psychology and Music Education Perspectives

Pediatric Anesthesia, EarlyView.
ABSTRACT Objective To evaluate the effects of perioperative music interventions on emotional outcomes (preoperative anxiety, postoperative fear, emergence delirium) and related physiological parameters in children and adolescents undergoing surgery, and to examine potential effect modifiers.
Yuchen Wen, Jinying Han, Jiayin Gao, Jiaqi Lou, Ziyi Xiang   +4 more
wiley   +1 more source

Psychological traffic calming [PDF]

, 2005
Excessive and inappropriate speeds are a major concern for road safety. Such speeds have an adverse effect on the number and severity of road traffic accidents and significantly reduce the quality of life in many urban and rural areas.
Department for Transport (Funder), Wheeler, A., , Department for Transport (Funder), Kennedy, Janet V., Gorell, R., Elliott, M.A., Crinson, L.   +6 more
core  

Effect of Road Markings on Speed Through Curves on Rural Roads: A Driving Simulator Study in Spain

Infrastructures
Traffic accidents remain a leading cause of mortality worldwide. In Spain, a total of 9666 accidents occurred on curves in 2023, highlighting the need for effective speed management strategies.
Santiago Martin-Castresana, Diego Alvarez, Fabian Andrade-Cataño, Maria Castro   +3 more
doaj   +1 more source

Proteomic Profiling of Primary Hippocampal Neurons Reveals Noncanonical GFAP Expression and Metabolic Adaptations in Glia‐Free Culture

PROTEOMICS, EarlyView.
ABSTRACT Despite their widespread use as a research model, a comprehensive, quantitative proteomic profile of the cultured hippocampal neurons has remained unexplored. Here, we provide the first global proteomic characterization of primary murine hippocampal neurons cultured for 14 days under near‐physiological glucose conditions (2.5 mM).
Dominika Drulis‐Fajdasz, Kinga Gostomska‐Pampuch, Natalia Pudełko‐Malik, Mariusz Fleszar, Agnieszka Gizak, Jacek R. Wiśniewski, Dariusz Rakus   +6 more
wiley   +1 more source

How does the novelty effect influence speed impacts? An exploratory meta-analysis of five types of traffic calming measures

Transportation Research Interdisciplinary Perspectives
Although traffic calming measures (TCMs) have been used internationally for several decades, their reported speed impacts remain inconsistent, partly due to differences in evaluation design and follow-up duration.
Jiří Ambros, Martin Šípek
doaj   +1 more source

Observations and numerical simulations of a valley‐exit wind in the Alpine Bolzano basin

Quarterly Journal of the Royal Meteorological Society, EarlyView.
The evolution and spreading of the nocturnal valley‐exit wind flowing from the Isarco Valley into the Bolzano basin, in the Italian Alps, are found to be influenced by the basin temperature stratification. Measurements and high‐resolution simulations show that a cold‐air pool favors an upward trajectory of the flow at the exit of the valley.
Federica Gucci, Andrea Zonato, Marco Falocchi, Dino Zardi, Lorenzo Giovannini   +4 more
wiley   +1 more source

The evolving role of regulatory T cells in Sjögren's disease pathogenesis and the promise of Treg‐based therapies: A comprehensive review

Rheumatology &Autoimmunity, EarlyView.
Graphical Abstract The evolving role of regulatory T cells in primary Sjögren's disease pathogenesis and the promise of Treg‐based therapies. Abstract Sjögren's disease (SjD) is a chronic systemic autoimmune disorder characterised by exocrine gland dysfunction and diverse systemic manifestations.
Gagan Urs, Bharath Raj Srinivasan, Himabindu Jayaprakash Narayan, Mirunalini Gobinath, Lekitha Manjunath, Mahabaleshwar Mamadapur   +5 more
wiley   +1 more source

Traffic Calming Measures as an Instrument for Revitalizing the Urban Environment

Sustainability
With the advent of rapid urbanization, cities are confronted with increasingly complex challenges [...]
Salvatore Leonardi, Natalia Distefano
openaire   +3 more sources

Promoting Climate‐Friendly Behaviour Under Cognitive and Coordination Constraints: A Multi‐Level Framework for Sustainable Development Governance

Sustainable Development, EarlyView.
ABSTRACT Despite widespread concern about climate change, climate‐friendly behaviour remains difficult to sustain in practice. This article argues that the core challenge lies less in insufficient motivation than in the cognitive and coordination demands imposed by prevailing decision environments.
Luca Lancini
wiley   +1 more source