Results 221 to 230 of about 3,001,389 (308)

Akkermansia muciniphila‐Derived N‐Acetylspermidine Modulates the Localization of Intestinal α1,2‐Fucosylated Proteins to Maintain Gut Homeostasis

Advanced Science, EarlyView.
This study demonstrates that Akkermansia muciniphila alleviates colitis by enhancing intestinal α1,2‐fucosylation through its metabolite N‐acetylspermidine. Mechanistically, N‐acetylspermidine‐induced PIM1 inhibition promotes HDAC2‐mediated reduction of chromatin accessibility at TP73, thereby upregulating C1GALT1C1 to boost α1,2‐fucosylation.
Ye Yao, Zhangming Pei, Yuanyuan Dai, Yinghan Chen, Zepeng Chang, Hongchao Wang, Jianxin Zhao, Hao Zhang, Qixiao Zhai, Wenwei Lu, Wei Chen   +10 more
wiley   +1 more source

Neuro‐Cancer Interactions Shape Glioma Intratumoral Heterogeneity

Advanced Science, EarlyView.
This review proposes a conceptual framework for understanding glioma intratumoral heterogeneity shaped by neuro‐cancer interactions: functional patterns and transcriptional states. Functional patterns manifest as three major neural‐like adaptations with spatial and potentially hierarchical relationships, including neurogliomal synapses, glioma networks,
Tong Wu, Peiran Zhao, Zheng Chen, Tianlei Ying, Zhihong Nie, Wei Hua, Huiyan Li, Ying Mao, Wenbo Bu   +8 more
wiley   +1 more source

Enhancing IoT cybersecurity through lean-based hybrid feature selection and ensemble learning: A visual analytics approach to intrusion detection. [PDF]

PLoS One
Zada I, Omran E, Jan S, Alfraihi H, Alsalamah S, Alshahrani A, Hayat S, Phi N.   +7 more
europepmc   +1 more source

Macrophage Zc3h12c Limits Tissue Inflammation and Injury via Alternative Splicing of Pre‐mRNA

Advanced Science, EarlyView.
This work defines the context‐dependent function of Zc3h12c in macrophages using the Tnfrsf11a‐Cre system. It reveals Zc3h12c's dual mechanism—regulating RNA degradation and alternative splicing—with STAT1 as a key target. The findings elucidate a novel post‐transcriptional pathway and identify STAT1 isoforms as potential therapeutic targets for kidney
Chenyu Li, Julian Aurelio Marschner, Yoshihiro Kusunoki, Ningxin Zhang, Xiaoxin Li, Hao Deng, Zhibo Zhao, Kanako Watanabe‐Kusunoki, Zhihui Zhu, Yan Xu, Stefanie Steiger, Maciej Lech, Katalin Susztak, Christian Schulz, Hans‐Joachim Anders   +14 more
wiley   +1 more source

Collaborative Split Learning-Based Dynamic Bandwidth Allocation for 6G-Grade TDM-PON Systems. [PDF]

Sensors (Basel)
Mohammed AFY, Allawi YM, Moneer EM, Widaa LO.   +3 more
europepmc   +1 more source

Florigen and Florigen‐Like Genes Regulate Temperature‐Responsive Flowering in Tomato

Advanced Science, EarlyView.
This study uncovers that FLOWERING LOCUS T‐Like 2 (FTL2) and SINGLE‐FLOWER TRUSS (SFT) antagonistically regulate temperature‐responsive flowering in the tomato shoot apical meristem. High temperature induces floral repressor FTL2, which directly inhibits SFT to delay short‐day floral transition, while SFT reciprocally inhibits FTL2 to promote flowering.
Jia Song, Shiqi Zhao, Siyu Fang, Xiaotian Wang, Shuai Sun, Baohua Li, Ren Li, Lu Liu, Xia Cui   +8 more
wiley   +1 more source

Correction: A Real Network Environment Dataset for Traffic Analysis. [PDF]

Sci Data
Jiang W, Zhang B, Zhu Q, Liao C, Wang W.
europepmc   +1 more source

Developing a Personalized Cancer Nanovaccine Using Coxsackievirus‐Reprogrammed Cancer Cell Membranes for Enhanced Anti‐Tumor Immunity

Advanced Science, EarlyView.
A personalized nanovaccine combining PLGA‐encapsulated heat‐inactivated CVB3 and membranes from CVB3‐infected breast cancer cells stimulates potent antitumor immunity. It reduces immunosuppressive markers, enhances immune activation, and improves survival in vivo.
Amirhossein Bahreyni, Yasir Mohamud, Amrit Singh, Razieh Sadat Banijamali, Jeffrey Tang, Jingchun Zhang, Honglin Luo   +6 more
wiley   +1 more source

Computer-vision based automatic rider helmet violation detection and vehicle identification in Indian smart city scenarios using NVIDIA TAO toolkit and YOLOv8. [PDF]

Front Artif Intell
Deshpande UU, Michael GKO, Araujo SDCS, Deshpande V, Patil R, Chate RAA, Tandur VR, Goudar SS, Ingale S, Charantimath V.   +9 more
europepmc   +1 more source

City-scale GPS data reveals impact of spatial configuration and dedicated infrastructure on e-scooter route choice. [PDF]

Sci Rep
Schumann HH, Haitao H, Meister A, Natapov A, Quddus M.   +4 more
europepmc   +1 more source