Results 221 to 230 of about 65,052 (313)

eIF4E Enriched Extracellular Vesicles Induce Immunosuppressive Macrophages through HMGCR‐Mediated Metabolic Rewiring

Advanced Science, EarlyView.
Here, it is revealed that ovarian cancer cells release extracellular vesicles enriched with eIF4E, which alters protein production in macrophages. This leads to increased expression of 3‐hydroxy‐3‐methyl‐glutaryl‐coenzyme A reductase (HMGCR), boosting cholesterol synthesis and activating an immunosuppressive pathway through X‐box binding protein 1 and ...
Sonam Mittal, Minal Nenwani, Ishaque Pulikkal Kadamberi, Sudhir Kumar, Olamide Animasahun, Jasmine George, Shirng‐Wern Tsaih, Prachi Gupta, Mona Singh, Anjali Geethadevi, Chandrima Dey, Noah Meurs, Ajay Shankaran, Pradeep Chaluvally Raghavan, Deepak Nagrath, Sunila Pradeep   +15 more
wiley   +1 more source

A car-following model of CAVs integrating state information from multiple leading and single following vehicles. [PDF]

Sci Rep
Chen Y, Cheng G.
europepmc   +1 more source

FGF9–FGFR2 Signaling via Osteocytes‐Preosteoblasts Crosstalks to Mediate Mechanotransduction‐Driven Intramembranous Osteogenesis in the Underdeveloped Maxilla

Advanced Science, EarlyView.
This study identifies osteocyte‐derived FGF9 as a mechanosensitive factor that impairs osteogenesis in the underdeveloped maxilla by inducing FGFR2 nuclear translocation in preosteoblasts. Mechanical stimulation reduces FGF9 secretion, relieving its inhibitory effect. These findings reveal a novel osteocyte–preosteoblast FGF9–FGFR2 axis in craniofacial
Yiwen Zhou, Lili Chen, Miaomiao Han, Peixiang Zhu, Yanyi Wang, Xuanxuan Yu, Tingyu Reng, Huijuan Wang, Baochao Li, Caixia Zhang, Ziwei Huang, Shuang Lin, Guoyun Wang, Jie Ge, Baosheng Guo, Huang Li   +15 more
wiley   +1 more source

Assessment of the stopping for right-turning large vehicles policy in Nanjing: Effectiveness and determinants. [PDF]

PLoS One
Zhu Y.
europepmc   +1 more source

Viral Systemic Movement Is Enhanced by Alteration of a Structural Phloem Protein by the Insect Vector

Advanced Science, EarlyView.
Aphids release salivary protein GLD into plants, which induces ROS in the phloem. This leads to the intermolecular disulfide bonds formation among SEO proteins, promoting their transition from the dispersed state to the aggregated state. SEO can interact with CMV CP.
Huijuan Guo, Qingyun Shi, Xiaoyu Ling, Yuting Wu, Lin He, Danyang Li, Keyan Zhu‐Salzman, Yucheng Sun   +7 more
wiley   +1 more source

Throughput and load balancing optimization in heterogeneous networks using Red-Tailed Hawk Algorithm. [PDF]

Sci Rep
Chandra I, Ramkumar K, Maram B, Krisagar PR, Tak TK.   +4 more
europepmc   +1 more source

Nanoshield‐Assisted Viral Gene Therapy with Induction of Non‐Apoptotic Cell Death and Durable Antitumor Immunity

Advanced Science, EarlyView.
A novel hybrid gene delivery platform combines adeno‐associated virus (AAV)‐mediated receptor‐interacting kinase 3 (RIPK3) expression with manganese dioxide‐polyethyleneimine (MnO2−PEI) nanoshield to induce necroptosis, ferroptosis, and immunogenic cell death, effectively reprogramming the tumor microenvironment.
Soo‐Hwan Lee, Yunkyeong Cho, Seunghwan Bang, Daeun Sung, Jahyun Koo, Seoyoung Kim, Youngil Koh, Hojun Kim, Hyojin Lee   +8 more
wiley   +1 more source

Scalable architecture for autonomous malware detection and defense in software-defined networks using federated learning approaches. [PDF]

Sci Rep
Ranpara R, Patel SK, Kumar OP, Al-Zahrani FA.   +3 more
europepmc   +1 more source

Diagnosis, Prognosis, and Drug Target Discovery for Chronic Widespread Pain: A Large Proteogenomic Study

Advanced Science, EarlyView.
Plasma proteomics is leveraged to decode the biological underpinnings of chronic widespread pain. A nested machine learning framework integrates proteomic signatures, prospective outcomes, and Mendelian randomization to uncover 18 causal proteins.
Li Chen, Eoin Kelleher, Ruogu Meng, Duanke Liu, Yuchen Guo, Yunhe Wang, Yaqing Gao, Zhe Huang, Zhu Liang, Shuai Yuan, Chao Zeng, Jun Ma, Yanhui Dong, Anushka Irani, Guanghua Lei, Junqing Xie, Daniel Prieto‐Alhambra   +16 more
wiley   +1 more source

STIL-TA: A new model of traffic flow forecasting based on spatiotemporal interactive learning and temporal attention. [PDF]

PLoS One
Chen L, Chen L, Wang H, Zhao J.
europepmc   +1 more source