Results 21 to 30 of about 3,001,389 (308)

An open source traffic engineering toolbox [PDF]

Computer Communications, 2006
We present the TOTEM open source Traffic Engineering (TE) toolbox and a set of TE methods that we have designed and/or integrated. These methods cover intra-domain and inter-domain TE, IP-based and MPLS-based TE. They are suitable for network optimisation, better routing of traffic for providing QoS, load balancing, protection and restoration in case ...
H. ímit, O. Delcourt, Simon Pietro Romano, Antonio Pescape, Sandford Bessler, Jordi Domingo-Pascual, X. Masip, H. T. Tran, Steve Uhlig, Fabian Skivée, Elio Salvadori, Maurizio D'Arienzo, Simon Balon, Ivan Gojmerac, Guy Leduc, S. Cerav-Erbas, Henrik Abrahamsson, Bruno Quoitin   +17 more
openaire   +6 more sources

C‐mannosylation promotes ADAMTS1 activation and secretion in human testicular germ cell tumor NEC8 cells

FEBS Letters, EarlyView.
C‐mannosylation is a unique form of protein glycosylation. In this study, we demonstrated that ADAMTS1 is C‐mannosylated at Trp562 and Trp565 in human testicular germ cell tumor NEC8 cells. We found that C‐mannosylation of ADAMTS1 is essential for its secretion, processing, enzymatic activity, and ability to promote vasculogenic mimicry. These findings
Takato Kobayashi, Takehiro Suzuki, Ryota Kawahara, Natsumi Harai, Naoshi Dohmae, Siro Simizu   +5 more
wiley   +1 more source

Escape from TGF‐β‐induced senescence promotes aggressive hallmarks in epithelial hepatocellular carcinoma cells

Molecular Oncology, EarlyView.
Chronic TGF‐β exposure drives epithelial HCC cells from a senescent state to a TGF‐β resistant mesenchymal phenotype. This transition is characterized by the loss of Smad3‐mediated signaling, escape from senescence, enhanced invasiveness and metastatic potential, and upregulation of key resistance modulators such as MARK1 and GRM8, ultimately promoting
Minenur Kalyoncu, Dilara Demirci, Sude Eris, Bengisu Dayanc, Ece Cakiroglu, Merve Basol, Merve Uysal, Gulcin Cakan‐Akdogan, Fang Liu, Mehmet Ozturk, Gökhan Karakülah, Serif Senturk   +11 more
wiley   +1 more source

Energy-aware traffic engineering in hybrid SDN/IP backbone networks [PDF]

Journal of Communications and Networks, 2016
Software defined network (SDN) can effectively improve the performance of traffic engineering and will be widely used in backbone networks. Therefore, new energy-saving schemes must take SDN into consideration; this action is extremely important owing to
Yunkai Wei, Xiaoning Zhang, Lei Xie, S. Leng   +3 more
semanticscholar   +1 more source

Tonic signaling of the B‐cell antigen‐specific receptor is a common functional hallmark in chronic lymphocytic leukemia cell phosphoproteomes at early disease stages

Molecular Oncology, EarlyView.
B‐cell chronic lymphocytic leukemia (B‐CLL) and monoclonal B‐cell lymphocytosis (MBL) show altered proteomes and phosphoproteomes, analyzed using mass spectrometry, protein microarrays, and western blotting. Identifying 2970 proteins and 316 phosphoproteins, including 55 novel phosphopeptides, we reveal BCR and NF‐kβ/STAT3 signaling in disease ...
Paula Díez, Pablo Juanes‐Velasco, Marina L. García‐Vaquero, Conrad Droste, Alicia Landeira‐Viñuela, Miguel Alcoceba, Helena Fidalgo‐Gómez, Sara Misiego‐Herrero, Almudena Navarro‐Bailón, Mónica Baile, José M. Bastida, Jose Manuel Sanchez‐Santos, Rafael Góngora, Julia Almeida, Marcos Gonzalez‐Diaz, Alberto Orfao, Javier De Las Rivas, Manuel Fuentes   +17 more
wiley   +1 more source

On the Interplay of Link-Flooding Attacks and Traffic Engineering [PDF]

CCRV, 2016
Link-flooding attacks have the potential to disconnect even entire countries from the Internet. Moreover, newly proposed indirect link-flooding attacks, such as ``Crossfire'', are extremely hard to expose and, subsequently, mitigate effectively.
Dimitrios Gkounis, Vasileios Kotronis, C. Liaskos, X. Dimitropoulos   +3 more
semanticscholar   +1 more source

Robust traffic engineering

2008 2nd International Symposium on Advanced Networks and Telecommunication Systems, 2008
Phenomenal growth of Internet applications in recent years have made it difficult to forecast traffic patterns. Daily Internet traffic patterns shows that the network is vulnerable to malicious attacks, flash crowds and denial of service attacks (DDoS).
Himanshu Agrawal, Andrew Jennings, Mark A. Gregory   +2 more
openaire   +3 more sources

Early metastasis is characterized by Gr1+ cell dysregulation and is inhibited by immunomodulatory nanoparticles

Molecular Oncology, EarlyView.
Breast cancer metastasis is associated with myeloid cell dysregulation and the lung‐specific accumulation of tumor‐supportive Gr1+ cells. Gr1+ cells support metastasis, in part, through a CHI3L1‐mediated mechanism, which can be targeted and inhibited with cargo‐free, polymeric nanoparticles.
Jeffrey A. Ma, Sophia M. Orbach, Kate V. Griffin, Kathryn Kang, Yining Zhang, Rebecca S. Pereles, Ian A. Schrack, Guillermo Escalona, Jacqueline S. Jeruss, Lonnie D. Shea   +9 more
wiley   +1 more source

Lying Your Way to Better Traffic Engineering [PDF]

Conference on Emerging Network Experiment and Technology, 2016
To optimize the flow of traffic in IP networks, operators do traffic engineering (TE), i.e., tune routing-protocol parameters in response to traffic demands.
Marco Chiesa, G. Rétvári, Michael Schapira   +2 more
semanticscholar   +1 more source

Data‐driven discovery of gene expression markers distinguishing pediatric acute lymphoblastic leukemia subtypes

Molecular Oncology, EarlyView.
This study investigates gene expression differences between two major pediatric acute lymphoblastic leukemia (ALL) subtypes, B‐cell precursor ALL, and T‐cell ALL, using a data‐driven approach consisting of biostatistics and machine learning methods. Following analysis of a discovery dataset, we find a set of 14 expression markers differentiating the ...
Mona Nourbakhsh, Nikola Tom, Anna Schrøder Lassen, Helene Brasch Lind Petersen, Ulrik Kristoffer Stoltze, Karin Wadt, Kjeld Schmiegelow, Matteo Tiberti, Elena Papaleo   +8 more
wiley   +1 more source