Results 51 to 60 of about 113,285 (311)
Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations
FEBS Letters, EarlyView.The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas +6 more
wiley +1 more source
Traffic engineering in ambient networks: challenges and approaches [PDF]
, 2004 The focus of this paper is on traffic engineering in ambient networks. We describe and categorize different alternatives for making the routing more adaptive to the current traffic situation and discuss the challenges that ambient networks pose on ...
Abrahamsson, Henrik, Gunnar, Anders
core
Journal of Advanced Transportation, 2023 Driving style identification is of vital importance for intelligent driving system design and urban traffic management. This study aims to identify and analyze driving styles using large-scale ride-hailing GPS data taking different time periods, traffic,
Ye Li +6 more
doaj +1 more source
The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome
FEBS Letters, EarlyView.This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley +1 more source
Assessment dynamic ratio for traffic loading on highway bridges
, 2011 The determination of characteristic bridge load effect is a complex problem. Usually, statistical extrapolation of simulated static load effects is used to derive a lifetime characteristic static load effect.
O\u27Brien, Eugene J. +4 more
core +1 more source
Journal of Advanced Transportation, 2023 Previous studies on pedestrian crossing have mostly focused on pedestrian crossing decisions; while as an important behavioral aspect, the pedestrian crossing process, i.e., their motions during the entire crossing process, has been narrowly studied ...
Ting Fu +6 more
doaj +1 more source
Content-aware traffic engineering [PDF]
Proceedings of the 12th ACM SIGMETRICS/PERFORMANCE joint international conference on Measurement and Modeling of Computer Systems, 2012 Recent studies show that a large fraction of Internet traffic is originated by Content Providers (CPs) such as content distribution networks and hyper-giants. To cope with the increasing demand for content, CPs deploy massively distributed server infrastructures.
Frank, B +4 more
openaire +4 more sources
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
Complexity, 2021 Clearance phase at signalized crosswalks is an important parameter of pedestrians’ safety because it helps them to complete the crossing before the green signal for vehicles.
Milan Simeunović +3 more
doaj +1 more source
Promet (Zagreb), 2023 This paper presents the main challenges of integrating micromobility vehicles into modern traffic and transportation systems. Although micromobility seems to be an effective concept for the first and last mile, the reality points to the potential ...
Branko Milovanović +5 more
doaj +1 more source