Results 61 to 70 of about 728,272 (252)

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang   +12 more
wiley   +1 more source

A Modified Latent Dirichlet Allocation Topic Approach for Driving Style Exploration Using Large-Scale Ride-Hailing GPS Data

open access: yesJournal of Advanced Transportation, 2023
Driving style identification is of vital importance for intelligent driving system design and urban traffic management. This study aims to identify and analyze driving styles using large-scale ride-hailing GPS data taking different time periods, traffic,
Ye Li   +6 more
doaj   +1 more source

Leveraging Personal Navigation Assistant Systems Using Automated Social Media Traffic Reporting

open access: yes, 2020
Modern urbanization is demanding smarter technologies to improve a variety of applications in intelligent transportation systems to relieve the increasing amount of vehicular traffic congestion and incidents.
Ghazzai, Hakim   +2 more
core   +1 more source

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

open access: yesMolecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak   +10 more
wiley   +1 more source

Multi-path Traffic Engineering Protocol Based on TeXCP [PDF]

open access: yesJisuanji gongcheng, 2018
In order to adapt to the real-time network traffic demand,and find the network fault in time,based on classic online distributed traffic engineering protocol TeXCP,this paper proposes Multi-path Traffic Engineering(MTE) protocol.The protocol consists of ...
YANG Yi,WU Zhaofeng,HU Guyu
doaj   +1 more source

Scalable BGP Prefix Selection for Effective Inter-domain Traffic Engineering

open access: yes, 2015
Inter-domain Traffic Engineering for multi-homed networks faces a scalability challenge, as the size of BGP routing table continue to grow. In this context, the choice of the best path must be made potentially for each destination prefix, requiring all ...
Devienne, Francois   +4 more
core   +1 more source

Checkpoint blockade and the stem‐like T cell trade‐off

open access: yesMolecular Oncology, EarlyView.
Stem‐like T cells are key to the success of programmed cell death protein 1 (PD1) blockade, as they sustain long‐term anti‐tumor response by continuously generating effector CD8+ T cells. However, how these cells are maintained in cancer is not fully understood. Hor et al.
Julie M. Mazet, Johanna A. Joyce
wiley   +1 more source

Selektivno letenje i njegove odrednice kao prvi stupanj odabira kandidata za pilotski poziv

open access: yesPromet (Zagreb), 2012
Flying as the vocational commitment of a person makes one of the most complex aspects of human activity. The beginning of materialization of such professional orientation refers to the selection of candidates for student-pilots at the Faculty of Traffic ...
Josip Njari
doaj   +1 more source

MPLS traffic engineering in satellite networks [PDF]

open access: yes, 2007
Broadband satellite constellation networks will be required to carry all types of IP traffic, real time interactive traffic as well as non-real time traffic, warranting the need for appropriate QoS for these different traffic flows.
Barolli, Leonard   +3 more
core   +1 more source

The role of lipid metabolism in neuronal senescence

open access: yesFEBS Open Bio, EarlyView.
Disrupted lipid metabolism, through alterations in lipid species or lipid droplet accumulation, can drive neuronal senescence. However, lipid dyshomeostasis can also occur alongside neuronal senescence, further amplifying tissue damage. Delineating how lipid‐induced senescence emerges in neurons and glial cells, and how it contributes to ageing and ...
Dikaia Tsagkari   +2 more
wiley   +1 more source

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