Results 61 to 70 of about 113,285 (311)

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

A New Individual Mobility Prediction Model Applicable to Both Ordinary Conditions and Large Crowding Events

Journal of Advanced Transportation, 2023
Accurate prediction of individual mobility is crucial for developing intelligent transportation systems. However, while previous models usually focused on predicting individual mobility under ordinary conditions, the models that are applicable to large ...
Bao Guo, Kaipeng Wang, Hu Yang, Fan Zhang, Pu Wang   +4 more
doaj   +1 more source

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Network Performance Implications of Variability in Data Traffic. [PDF]

, 2000
World Wide Web (WWW) traffic will dominate network traffic for the foreseeable future. Accurate predictions of network performance can only be achieved if network models reflect WWW traffic statistics.
Roadknight, Chris, Marshall, Ian W., Bilchev, George   +2 more
core  

Multi-path Traffic Engineering Protocol Based on TeXCP [PDF]

Jisuanji gongcheng, 2018
In order to adapt to the real-time network traffic demand,and find the network fault in time,based on classic online distributed traffic engineering protocol TeXCP,this paper proposes Multi-path Traffic Engineering(MTE) protocol.The protocol consists of ...
YANG Yi,WU Zhaofeng,HU Guyu
doaj   +1 more source

Traffic engineering in metro ethernet [PDF]

IEEE Network, 2005
Traffic engineering is a critical issue that has to be addressed in metro Ethernet networks for proper and efficient resource utilization as well as facilitating quality of service. This article aims at understanding the relevant issues and outlines novel algorithms for multipoint-TE in the metro Ethernet.
M. Ali, G. Chiruvolu, null An Ge, null Alcatel   +3 more
openaire   +1 more source

Identification of functional murine mitochondrial formyl peptides and their effects on myeloid‐derived suppressor cell generation

FEBS Open Bio, EarlyView.
We first identified functional murine mitochondrial N‐formyl peptides (MT‐FPs) and investigated their effects on the in vitro myeloid‐derived suppressor cell (MDSC) generation from bone marrow cells. We demonstrated that MT‐FPs acted directly on bone marrow cells to promote MDSC generation and modulated the polymorphonuclear (PMN)‐MDSC/monocyte (M ...
Miyako Ozawa, Saori Kagoshima, Akira Yamada   +2 more
wiley   +1 more source

Characteristic dynamic traffic load effects in bridges

, 2009
When formulating an approach to assess bridge traffic loading with allowance for Vehicle-Bridge Interaction (VBI), a trade-off is necessary between the limited accuracy and computational demands of numerical models and the limited time periods for which ...
O\u27Brien, Eugene J., Dowling, Jason, O'Brien, Eugene J., Znidaric, Ales, Aleš Žnidarič, Arturo González, Paraic Rattigan, Rattigan, Paraic, González, Arturo, Eugene J. OBrien, Jason Dowling   +10 more
core   +1 more source

Selektivno letenje i njegove odrednice kao prvi stupanj odabira kandidata za pilotski poziv

Promet (Zagreb), 2012
Flying as the vocational commitment of a person makes one of the most complex aspects of human activity. The beginning of materialization of such professional orientation refers to the selection of candidates for student-pilots at the Faculty of Traffic ...
Josip Njari
doaj   +1 more source