Results 81 to 90 of about 144,271 (315)

Unraveling 4‐Phenylbutyrate's Therapeutic Role in SLC6A1 Disorders: Pharmacochaperoning Over HDAC Inhibition

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Variants in SLC6A1, encoding the GABA transporter 1 (GAT‐1), cause epilepsy, autism spectrum disorder, and developmental delay via loss of GABA uptake, impaired trafficking, and ER retention. We previously found that 4‐Phenylbutyrate (PBA), an FDA‐approved drug, restores GABA uptake and reduces seizures in SLC6A1‐related disorders ...
Melissa B. DeLeeuw   +5 more
wiley   +1 more source

Towards a benchmarking of Microscopic Traffic Flow Models

open access: yes, 2003
Several microscopic traffic models have been tested with a publicly available data set. The task was to predict the travel times between sever observers along a one-lane rural road, given as boundary conditions the flow into this road and the flow out of
Brockfeld, Elmar   +3 more
core  

Measuring and Modelling of the Traffic Flow at Microscopic Level

open access: yes, 2004
The traffic flow theory is dealing with the better understandingof the traffic flow and its improvement. Most often, the researchedsubject was been the road traffic.
Rudi Čop, Milan Batista
core   +1 more source

Human Pegivirus Encephalitis With Brain Detection and Response to Sofosbuvir Ledipasvir

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Human pegivirus (HPgV‐1) has been associated with severe encephalomyelitis in immunocompromised patients. Its neurological spectrum remains poorly defined. We report a slowly progressive encephalitis in a person living with well‐controlled HIV, characterized by white matter abnormalities and inflammatory cerebrospinal fluid (CSF). HPgV RNA was
Antoine Moulignier   +3 more
wiley   +1 more source

Statistical physics of traffic flow [PDF]

open access: yesPhysica A: Statistical Mechanics and its Applications, 2000
23 pages, 18 figures, uses Elsevier ...
openaire   +2 more sources

Calibration and Validation of Microscopic Traffic Flow Models

open access: yes, 2004
Microscopic simulation models are becoming increasingly important tools in modeling transport systems. There are a large number of available models used in many countries.
Brockfeld, Elmar   +2 more
core  

Intrinsic Photoactive Star ZnPc–Poly(glutamate) Nanoplatforms for Multimodal Glioblastoma Therapy and Brain‐Targeted Delivery

open access: yesAdvanced Functional Materials, EarlyView.
An intrinsic photoactive star‐shaped zinc phtalocyanine‐poly(L‐glutamic acid) (ZnPc‐PGA) nanoplatform for multimodal glioblastoma (GBM) therapy and brain‐targeted elivery. A ZnPc‐PGA‐based multifunctional theranostic nanocarrier platform enables image‐guided, multimodal GBM therapy. ZnPc‐PGA nanocarriers support the integration of fluorescence imaging,
Amina Benaicha‐Fernández   +14 more
wiley   +1 more source

Traffic Oscillations Mitigation in Vehicle Platoon Using a Car-Following Control Model for Connected and Autonomous Vehicle

open access: yesJournal of Advanced Transportation, 2019
Traffic oscillations often occur in road traffic, they make traffic flow unstable, unsafe and inefficient. Emerging connected and autonomous vehicle (CAV) technologies are potential solutions to mitigating the traffic oscillations for the advantages that
Zhijun Gao   +6 more
doaj   +1 more source

The development of decision support models for European air traffic flow management [PDF]

open access: yes
Congestion severely affects air traffic in the US and Europe. To protect air traffic controllers from overloads a planning activity, Air Traffic Flow Management (ATFM), emerged during the 1970s.
De Matos, Paula Alexandra Leal
core  

Traffic Flow Characteristics with Transportation Plans Components

open access: yes, 2012
Knowledge of traffic characteristics is useful to the highwayengineer in developing highway and transportation plans, performingeconomic analyses, establishing geometric design criteria,selecting and implementing traffic control measures, andevaluating ...
Hrvoje Baričević, Čedomir Dundović
core   +1 more source

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