Results 71 to 80 of about 144,271 (315)

Epilepsy‐Associated Variants of a Single SCN1A Codon Exhibit Divergent Functional Properties

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Pathogenic variants in SCN1A, which encodes the voltage‐gated sodium channel NaV1.1, are associated with multiple epilepsy syndromes exhibiting a range of clinical severity. SCN1A variants are reported in different syndromes, including Dravet syndrome, which is associated with loss‐of‐function, whereas neonatal/infantile‐onset ...
Lanie N. Liebovitz, Christopher H. Thompson, Linda C. Laux, Alfred L. George Jr.   +3 more
wiley   +1 more source

The Application of Cusp Catastrophe Theory to Analyze Road Traffic Potential Characteristics, Considering Headway, with Urban Data

Mathematics
Local data are essential for the analysis of abrupt conditions in traffic flow. In this research, we address the shortcomings of real-time traffic flow detection data, which inadequately represent the density characteristics of vehicular traffic.
Jian Gu, Zining Zeng, Shun Li, Wei Jing, Fuan Huang   +4 more
doaj   +1 more source

Evaluation of Impacts of Adaptive Cruise Control on Mixed Traffic Flow [PDF]

This paper addresses the impacts of Adaptive (Intelligent) Cruise Control (ACC) laws on traffic flow. Semi-automated vehicles, such as ACC Vehicles, with the capability to automatically follow each other in the same lane, will coexist with manually ...
Xi Zou, David Levinson
core  

Cracking the Code: Genotype–Phenotype Correlation Models in Sarcoglycanopathies

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Sarcoglycanopathies are among the most severe limb‐girdle muscular dystrophies (LGMD), though milder presentations have been described. These diseases are primarily caused by missense variants, but the limited predictability of their effect on protein maturation, complex formation, and transport has hindered reliable genotype ...
Leonela Luce, Goknur Selen Kocak, José Verdú‐Díaz, Jorge Alonso‐Pérez, Kristl G. Claeys, Tanya Stojkovic, Gorka Fernández‐Eulate, Pascal Laforêt, Najoua Miladi, Filipe Di Pace, Cristiane Araujo Martins Moreno, Edmar Zanoteli, Conrad C. Weihl, Volker Straub, Ana Töpf, Jordi Díaz‐Manera, Sarcoglycan European Cohort Consortium, Adele D′Amico, Adolfo López de Munain, Alicia Alonso‐Jiménez, Ana Camacho‐Salas, Andrea Gangfuß, Andrés Nascimento, Anna Sarkozy, Anneke J. van der Kooi, Arturo Fraga‐Bau, Béla Melegh, Benedikt Schoser, Bjarne Udd, Blaz Koritnik, Carlos Ortez, Chiara Marini Bettolo, Chiara Panicucci, Claudia Weiss, Claudio Bruno, Claudio Semplicini, Cristina Dominguez‐González, Cristina Garrido, David Gómez‐Andrés, Edoardo Malfatti, Elena Pegoraro, Elke De Vos, Francina Munell, Gabriele Dekomien, Giacomo Pietro Comi, Giorgio Tasca, Isabelle Richard, Jan L. De Bleecker, Jana Haberlová, Jesper Helbo Storgaard, Johanna Palmio, John Vissing, Juan Carlos de Leon‐Hernández, Kinga Hadzsiev, Laura Costa‐Comellas, Lea Leonardis, Leroy ten Dam, Lidia González‐Quereda, Luca Bello, Luisa Politano, Manuela Santos, Marianne de Visser, Marie Rohlenová, Matteo Garibaldi, Michela Guglieri, Nicolas Deconinck, Nicoline Løkken, Omar Abdel‐Mannan, Pia Gallano, Roberto Fernández‐Torrón, Ulrike Schara‐Schmidt, Vincenzo Nigro, Vittoria Zangaro   +72 more
wiley   +1 more source

The Effect of Crosswalks on Traffic Flow

European Journal of Transport and Infrastructure Research, 2018
In urban areas and especially in inner cities, pedestrians crossing the road considerably influence the road traffic flow. For political reasons, priority could be given to pedestrians. A larger number of crossings reduces the pedestrian load per crossing and facilitates both the pedestrian flow and the car flow; the ultimate case is a “cross anywhere”
Knoop, V.L. (author), Daganzo, Carlos F. (author)   +1 more
openaire   +2 more sources

Space-time modeling of traffic flow [PDF]

A key concern in transportation planning and traffic management is the ability to forecast traffic flows on a street network. Traffic flows forecasts can be transformed to obtain travel time estimates and then use these as input to travel demand models ...
Prastacos, Poulicos, Kamarianakis, Yiannis   +1 more
core  

The influence of meteorology, urban topography and traffic on the variability in concentrations of a traffic-related pollutant in urban street canyons [PDF]

, 2005
A comprehensive study into the spatial and temporal variations in concentrations of a traffic-related pollutant was undertaken in two urban street canyons located in York, U. K.
Boddy, John William Douglas
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Sertraline Treatment Can Mimic Niemann‐Pick Type C Biomarker Profile: A Diagnostic Pitfall

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Oxysterols (cholestane‐3β,5α,6β‐triol and 7‐ketocholesterol) and N‐palmitoyl‐O‐phosphocholineserine (PPCS) are sensitive biomarkers for Niemann‐Pick disease type C (NPC) screening. However, false‐positive results occur, with a biomarker profile suggestive of NPC despite the absence of pathogenic variants in genes involved in NPC or ...
Maria Makrygianni, Cecile Pagan, Antony Citterio‐Quentin, Isabelle Rouvet, Giulia Dingeo, Cyril Hanin, Claudine Laurent‐Levinson, Samia Pichard, Bénédicte Héron, Clément Gourguechon, Daniele Mandia, Jerome Guitton, Carole Lacout, Nicolas Schleinitz, Florient Potier, Olivier Flabeau, Elsa Besse‐Pinot, Foudil Lamari, Magali Pettazzoni, Yann Nadjar   +19 more
wiley   +1 more source

Traffic flow modelling of long and short trucks using a hybrid artificial neural network optimized by particle swarm optimization

International Journal of Transportation Science and Technology
The significance of intelligent transportation systems and artificial intelligence in road transportation networks has made the prediction of traffic flow a subject of discussion among transportation engineers, urban planners, and researchers in the last
Isaac Oyeyemi Olayode, Bo Du, Lagouge Kwanda Tartibu, Frimpong Justice Alex   +3 more
doaj   +1 more source

Self-Organizing Traffic at a Malfunctioning Intersection [PDF]

Traffic signals and traffic flow models have been studied extensively in the past and have provided valuable insights on the design of signalling systems, congestion control, and punitive policies. This paper takes a slightly different tack and describes
Sugata Mitra, Sujai Kumar
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